For medical image segmentation, contrastive learning is the dominant practice to improve the quality of visual representations by contrasting semantically similar and dissimilar pairs of samples. This is enabled by the observation that without accessing ground truth labels, negative examples with truly dissimilar anatomical features, if sampled, can significantly improve the performance. In reality, however, these samples may come from similar anatomical regions and the models may struggle to distinguish the minority tail-class samples, making the tail classes more prone to misclassification, both of which typically lead to model collapse. In this paper, we propose ARCO, a semi-supervised contrastive learning (CL) framework with stratified group theory for medical image segmentation. In particular, we first propose building ARCO through the concept of variance-reduced estimation and show that certain variance-reduction techniques are particularly beneficial in pixel/voxel-level segmentation tasks with extremely limited labels. Furthermore, we theoretically prove these sampling techniques are universal in variance reduction. Finally, we experimentally validate our approaches on eight benchmarks, i.e., five 2D/3D medical and three semantic segmentation datasets, with different label settings, and our methods consistently outperform state-of-the-art semi-supervised methods. Additionally, we augment the CL frameworks with these sampling techniques and demonstrate significant gains over previous methods. We believe our work is an important step towards semi-supervised medical image segmentation by quantifying the limitation of current self-supervision objectives for accomplishing such challenging safety-critical tasks.

Recent advancements in large language models (LLMs) have transformed the field of question answering (QA). However, evaluating LLMs in the medical field is challenging due to the lack of standardized and comprehensive datasets. To address this gap, we introduce CMExam, sourced from the Chinese National Medical Licensing Examination. CMExam consists of 60K+ multiple-choice questions for standardized and objective evaluations, as well as solution explanations for model reasoning evaluation in an open-ended manner. For in-depth analyses of LLMs, we invited medical professionals to label five additional question-wise annotations, including disease groups, clinical departments, medical disciplines, areas of competency, and question difficulty levels. Alongside the dataset, we further conducted thorough experiments with representative LLMs and QA algorithms on CMExam. The results show that GPT-4 had the best accuracy of 61.6% and a weighted F1 score of 0.617. These results highlight a great disparity when compared to human accuracy, which stood at 71.6%. For explanation tasks, while LLMs could generate relevant reasoning and demonstrate improved performance after finetuning, they fall short of a desired standard, indicating ample room for improvement. To the best of our knowledge, CMExam is the first Chinese medical exam dataset to provide comprehensive medical annotations. The experiments and findings of LLM evaluation also provide valuable insights into the challenges and potential solutions in developing Chinese medical QA systems and LLM evaluation pipelines. The dataset and relevant code are available at https://github.com/williamliujl/CMExam.

Recently, the fast development of Large Language Models (LLMs) such as ChatGPT has significantly advanced NLP tasks by enhancing the capabilities of conversational models. However, the application of LLMs in the recommendation domain has not been thoroughly investigated. To bridge this gap, we propose LLMRec, a LLM-based recommender system designed for benchmarking LLMs on various recommendation tasks. Specifically, we benchmark several popular off-the-shelf LLMs, such as ChatGPT, LLaMA, ChatGLM, on five recommendation tasks, including rating prediction, sequential recommendation, direct recommendation, explanation generation, and review summarization. Furthermore, we investigate the effectiveness of supervised finetuning to improve LLMs' instruction compliance ability. The benchmark results indicate that LLMs displayed only moderate proficiency in accuracy-based tasks such as sequential and direct recommendation. However, they demonstrated comparable performance to state-of-the-art methods in explainability-based tasks. We also conduct qualitative evaluations to further evaluate the quality of contents generated by different models, and the results show that LLMs can truly understand the provided information and generate clearer and more reasonable results. We aspire that this benchmark will serve as an inspiration for researchers to delve deeper into the potential of LLMs in enhancing recommendation performance. Our codes, processed data and benchmark results are available at https://github.com/williamliujl/LLMRec.

Medical data often exhibits long-tail distributions with heavy class imbalance, which naturally leads to difficulty in classifying the minority classes (i.e., boundary regions or rare objects). Recent work has significantly improved semi-supervised medical image segmentation in long-tailed scenarios by equipping them with unsupervised contrastive criteria. However, it remains unclear how well they will perform in the labeled portion of data where class distribution is also highly imbalanced. In this work, we present ACTION++, an improved contrastive learning framework with adaptive anatomical contrast for semi-supervised medical segmentation. Specifically, we propose an adaptive supervised contrastive loss, where we first compute the optimal locations of class centers uniformly distributed on the embedding space (i.e., off-line), and then perform online contrastive matching training by encouraging different class features to adaptively match these distinct and uniformly distributed class centers. Moreover, we argue that blindly adopting a constant temperature $\tau$ in the contrastive loss on long-tailed medical data is not optimal, and propose to use a dynamic $\tau$ via a simple cosine schedule to yield better separation between majority and minority classes. Empirically, we evaluate ACTION++ on ACDC and LA benchmarks and show that it achieves state-of-the-art across two semi-supervised settings. Theoretically, we analyze the performance of adaptive anatomical contrast and confirm its superiority in label efficiency.

Integrating high-level semantically correlated contents and low-level anatomical features is of central importance in medical image segmentation. Towards this end, recent deep learning-based medical segmentation methods have shown great promise in better modeling such information. However, convolution operators for medical segmentation typically operate on regular grids, which inherently blur the high-frequency regions, i.e., boundary regions. In this work, we propose MORSE, a generic implicit neural rendering framework designed at an anatomical level to assist learning in medical image segmentation. Our method is motivated by the fact that implicit neural representation has been shown to be more effective in fitting complex signals and solving computer graphics problems than discrete grid-based representation. The core of our approach is to formulate medical image segmentation as a rendering problem in an end-to-end manner. Specifically, we continuously align the coarse segmentation prediction with the ambiguous coordinate-based point representations and aggregate these features to adaptively refine the boundary region. To parallelly optimize multi-scale pixel-level features, we leverage the idea from Mixture-of-Expert (MoE) to design and train our MORSE with a stochastic gating mechanism. Our experiments demonstrate that MORSE can work well with different medical segmentation backbones, consistently achieving competitive performance improvements in both 2D and 3D supervised medical segmentation methods. We also theoretically analyze the superiority of MORSE.

Recommendation systems suffer in the strict cold-start (SCS) scenario, where the user-item interactions are entirely unavailable. The ID-based approaches completely fail to work. Cold-start recommenders, on the other hand, leverage item contents to map the new items to the existing ones. However, the existing SCS recommenders explore item contents in coarse-grained manners that introduce noise or information loss. Moreover, informative data sources other than item contents, such as users' purchase sequences and review texts, are ignored. We explore the role of the fine-grained item attributes in bridging the gaps between the existing and the SCS items and pre-train a knowledgeable item-attribute graph for SCS item recommendation. Our proposed framework, ColdGPT, models item-attribute correlations into an item-attribute graph by extracting fine-grained attributes from item contents. ColdGPT then transfers knowledge into the item-attribute graph from various available data sources, i.e., item contents, historical purchase sequences, and review texts of the existing items, via multi-task learning. To facilitate the positive transfer, ColdGPT designs submodules according to the natural forms of the data sources and coordinates the multiple pre-training tasks via unified alignment-and-uniformity losses. Our pre-trained item-attribute graph acts as an implicit, extendable item embedding matrix, which enables the SCS item embeddings to be easily acquired by inserting these items and propagating their attributes' embeddings. We carefully process three public datasets, i.e., Yelp, Amazon-home, and Amazon-sports, to guarantee the SCS setting for evaluation. Extensive experiments show that ColdGPT consistently outperforms the existing SCS recommenders by large margins and even surpasses models that are pre-trained on 75-224 times more, cross-domain data on two out of four datasets.

While a large body of literature suggests that large language models (LLMs) acquire rich linguistic representations, little is known about whether they adapt to linguistic biases in a human-like way. The present study probes this question by asking whether LLMs display human-like referential biases using stimuli and procedures from real psycholinguistic experiments. Recent psycholinguistic studies suggest that humans adapt their referential biases with recent exposure to referential patterns; closely replicating three relevant psycholinguistic experiments from Johnson & Arnold (2022) in an in-context learning (ICL) framework, we found that InstructGPT adapts its pronominal interpretations in response to the frequency of referential patterns in the local discourse, though in a limited fashion: adaptation was only observed relative to syntactic but not semantic biases. By contrast, FLAN-UL2 fails to generate meaningful patterns. Our results provide further evidence that contemporary LLMs discourse representations are sensitive to syntactic patterns in the local context but less so to semantic patterns. Our data and code are available at \url{https://github.com/zkx06111/llm_priming}.

Recent advancements in self-supervised learning have demonstrated that effective visual representations can be learned from unlabeled images. This has led to increased interest in applying self-supervised learning to the medical domain, where unlabeled images are abundant and labeled images are difficult to obtain. However, most self-supervised learning approaches are modeled as image level discriminative or generative proxy tasks, which may not capture the finer level representations necessary for dense prediction tasks like multi-organ segmentation. In this paper, we propose a novel contrastive learning framework that integrates Localized Region Contrast (LRC) to enhance existing self-supervised pre-training methods for medical image segmentation. Our approach involves identifying Super-pixels by Felzenszwalb's algorithm and performing local contrastive learning using a novel contrastive sampling loss. Through extensive experiments on three multi-organ segmentation datasets, we demonstrate that integrating LRC to an existing self-supervised method in a limited annotation setting significantly improves segmentation performance. Moreover, we show that LRC can also be applied to fully-supervised pre-training methods to further boost performance.

Contrastive learning has shown great promise over annotation scarcity problems in the context of medical image segmentation. Existing approaches typically assume a balanced class distribution for both labeled and unlabeled medical images. However, medical image data in reality is commonly imbalanced (i.e., multi-class label imbalance), which naturally yields blurry contours and usually incorrectly labels rare objects. Moreover, it remains unclear whether all negative samples are equally negative. In this work, we present ACTION, an Anatomical-aware ConTrastive dIstillatiON framework, for semi-supervised medical image segmentation. Specifically, we first develop an iterative contrastive distillation algorithm by softly labeling the negatives rather than binary supervision between positive and negative pairs. We also capture more semantically similar features from the randomly chosen negative set compared to the positives to enforce the diversity of the sampled data. Second, we raise a more important question: Can we really handle imbalanced samples to yield better performance? Hence, the key innovation in ACTION is to learn global semantic relationship across the entire dataset and local anatomical features among the neighbouring pixels with minimal additional memory footprint. During the training, we introduce anatomical contrast by actively sampling a sparse set of hard negative pixels, which can generate smoother segmentation boundaries and more accurate predictions. Extensive experiments across two benchmark datasets and different unlabeled settings show that ACTION significantly outperforms the current state-of-the-art semi-supervised methods.

Table pretrain-then-finetune paradigm has been proposed and employed at a rapid pace after the success of pre-training in the natural language domain. Despite the promising findings in tabular pre-trained language models (TPLMs), there is an input gap between pre-training and fine-tuning phases. For instance, TPLMs jointly pre-trained with table and text input could be effective for tasks also with table-text joint input like table question answering, but it may fail for tasks with only tables or text as input such as table retrieval. To this end, we propose UTP, an approach that dynamically supports three types of multi-modal inputs: table-text, table, and text. Specifically, UTP is pre-trained with two strategies: (1) We first utilize a universal mask language modeling objective on each kind of input, enforcing the model to adapt various inputs. (2) We then present Cross-Modal Contrastive Regularization (CMCR), which utilizes contrastive learning to encourage the consistency between table-text cross-modality representations via unsupervised instance-wise training signals during pre-training. By these means, the resulting model not only bridges the input gap between pre-training and fine-tuning but also advances in the alignment of table and text. Extensive results show UTP achieves superior results on uni-modal input tasks (e.g., table retrieval) and cross-modal input tasks (e.g., table question answering).