Computed tomography (CT)-guided needle biopsies are critical for diagnosing a range of conditions, including lung cancer, but present challenges such as limited in-bore space, prolonged procedure times, and radiation exposure. Robotic assistance offers a promising solution by improving needle trajectory accuracy, reducing radiation exposure, and enabling real-time adjustments. In our previous work, we introduced a redundant robotic platform designed for dexterous needle insertion within the confined CT bore. However, its limited base mobility restricts flexible deployment in clinical settings. In this study, we present an improved 11-degree-of-freedom (DOF) robotic system that integrates a 6-DOF robotic base with a 5-DOF cable-driven end-effector, significantly enhancing workspace flexibility and precision. With the hyper-redundant degrees of freedom, we introduce a weighted inverse kinematics controller with a two-stage priority scheme for large-scale movement and fine in-bore adjustments, along with a null-space control strategy to optimize dexterity. We validate our system through both simulation and real-world experiments, demonstrating superior tracking accuracy and enhanced manipulability in CT-guided procedures. The study provides a strong case for hyper-redundancy and null-space control formulations for robot-assisted needle biopsy scenarios.

The increasing demand for healthcare workers, driven by aging populations and labor shortages, presents a significant challenge for hospitals. Humanoid robots have the potential to alleviate these pressures by leveraging their human-like dexterity and adaptability to assist in medical procedures. This work conducted an exploratory study on the feasibility of humanoid robots performing direct clinical tasks through teleoperation. A bimanual teleoperation system was developed for the Unitree G1 Humanoid Robot, integrating high-fidelity pose tracking, custom grasping configurations, and an impedance controller to safely and precisely manipulate medical tools. The system is evaluated in seven diverse medical procedures, including physical examinations, emergency interventions, and precision needle tasks. Our results demonstrate that humanoid robots can successfully replicate critical aspects of human medical assessments and interventions, with promising quantitative performance in ventilation and ultrasound-guided tasks. However, challenges remain, including limitations in force output for procedures requiring high strength and sensor sensitivity issues affecting clinical accuracy. This study highlights the potential and current limitations of humanoid robots in hospital settings and lays the groundwork for future research on robotic healthcare integration.

Depth perception is essential for a robot's spatial and geometric understanding of its environment, with many tasks traditionally relying on hardware-based depth sensors like RGB-D or stereo cameras. However, these sensors face practical limitations, including issues with transparent and reflective objects, high costs, calibration complexity, spatial and energy constraints, and increased failure rates in compound systems. While monocular depth estimation methods offer a cost-effective and simpler alternative, their adoption in robotics is limited due to their output of relative rather than metric depth, which is crucial for robotics applications. In this paper, we propose a method that utilizes a single calibrated camera, enabling the robot to act as a ``measuring stick" to convert relative depth estimates into metric depth in real-time as tasks are performed. Our approach employs an LSTM-based metric depth regressor, trained online and refined through probabilistic filtering, to accurately restore the metric depth across the monocular depth map, particularly in areas proximal to the robot's motion. Experiments with real robots demonstrate that our method significantly outperforms current state-of-the-art monocular metric depth estimation techniques, achieving a 22.1% reduction in depth error and a 52% increase in success rate for a downstream task.

Chronic wounds, including diabetic ulcers, pressure ulcers, and ulcers secondary to venous hypertension, affects more than 6.5 million patients and a yearly cost of more than $25 billion in the United States alone. Chronic wound treatment is currently a manual process, and we envision a future where robotics and automation will aid in this treatment to reduce cost and improve patient care. In this work, we present the development of the first robotic system for wound dressing removal which is reported to be the worst aspect of living with chronic wounds. Our method leverages differentiable physics-based simulation to perform gradient-based Model Predictive Control (MPC) for optimized trajectory planning. By integrating fracture mechanics of adhesion, we are able to model the peeling effect inherent to dressing adhesion. The system is further guided by carefully designed objective functions that promote both efficient and safe control, reducing the risk of tissue damage. We validated the efficacy of our approach through a series of experiments conducted on both synthetic skin phantoms and real human subjects. Our results demonstrate the system's ability to achieve precise and safe dressing removal trajectories, offering a promising solution for automating this essential healthcare procedure.

Surgical automation has the capability to improve the consistency of patient outcomes and broaden access to advanced surgical care in underprivileged communities. Shared autonomy, where the robot automates routine subtasks while the surgeon retains partial teleoperative control, offers great potential to make an impact. In this paper we focus on one important skill within surgical shared autonomy: Automating robotic assistance to maximize visual exposure and apply tissue tension for dissection and cautery. Ensuring consistent exposure to visualize the surgical site is crucial for both efficiency and patient safety. However, achieving this is highly challenging due to the complexities of manipulating deformable volumetric tissues that are prevalent in surgery.To address these challenges we propose \methodname, a framework for autonomous surgical robotic assistance to \methodfullname. We integrate a differentiable physics model with perceptual feedback to achieve our two key objectives: 1) Maximizing tissue exposure and applying tension for a specified dissection site through visual-servoing conrol and 2) Selecting optimal control positions for a dissection target based on deformable Jacobian analysis. We quantitatively assess our method through repeated real robot experiments on a tissue phantom, and showcase its capabilities through dissection experiments using shared autonomy on real animal tissue.

Motion planning is integral to robotics applications such as autonomous driving, surgical robots, and industrial manipulators. Existing planning methods lack scalability to higher-dimensional spaces, while recent learning based planners have shown promise in accelerating sampling-based motion planners (SMP) but lack generalizability to out-of-distribution environments. To address this, we present a novel approach, Vector Quantized-Motion Planning Transformers (VQ-MPT) that overcomes the key generalization and scaling drawbacks of previous learning-based methods. VQ-MPT consists of two stages. Stage 1 is a Vector Quantized-Variational AutoEncoder model that learns to represent the planning space using a finite number of sampling distributions, and stage 2 is an Auto-Regressive model that constructs a sampling region for SMPs by selecting from the learned sampling distribution sets. By splitting large planning spaces into discrete sets and selectively choosing the sampling regions, our planner pairs well with out-of-the-box SMPs, generating near-optimal paths faster than without VQ-MPT's aid. It is generalizable in that it can be applied to systems of varying complexities, from 2D planar to 14D bi-manual robots with diverse environment representations, including costmaps and point clouds. Trained VQ-MPT models generalize to environments unseen during training and achieve higher success rates than previous methods.

Accurate deformable object manipulation (DOM) is essential for achieving autonomy in robotic surgery, where soft tissues are being displaced, stretched, and dissected. Many DOM methods can be powered by simulation, which ensures realistic deformation by adhering to the governing physical constraints and allowing for model prediction and control. However, real soft objects in robotic surgery, such as membranes and soft tissues, have complex, anisotropic physical parameters that a simulation with simple initialization from cameras may not fully capture. To use the simulation techniques in real surgical tasks, the "real-to-sim" gap needs to be properly compensated. In this work, we propose an online, adaptive parameter tuning approach for simulation optimization that (1) bridges the real-to-sim gap between a physics simulation and observations obtained 3D perceptions through estimating a residual mapping and (2) optimizes its stiffness parameters online. Our method ensures a small residual gap between the simulation and observation and improves the simulation's predictive capabilities. The effectiveness of the proposed mechanism is evaluated in the manipulation of both a thin-shell and volumetric tissue, representative of most tissue scenarios. This work contributes to the advancement of simulation-based deformable tissue manipulation and holds potential for improving surgical autonomy.

Cloth manipulation is a category of deformable object manipulation of great interest to the robotics community, from applications of automated laundry-folding and home organizing and cleaning to textiles and flexible manufacturing. Despite the desire for automated cloth manipulation, the thin-shell dynamics and under-actuation nature of cloth present significant challenges for robots to effectively interact with them. Many recent works omit explicit modeling in favor of learning-based methods that may yield control policies directly. However, these methods require large training sets that must be collected and curated. In this regard, we create a framework for differentiable modeling of cloth dynamics leveraging an Extended Position-based Dynamics (XPBD) algorithm. Together with the desired control objective, physics-aware regularization terms are designed for better results, including trajectory smoothness and elastic potential energy. In addition, safety constraints, such as avoiding obstacles, can be specified using signed distance functions (SDFs). We formulate the cloth manipulation task with safety constraints as a constrained optimization problem, which can be effectively solved by mainstream gradient-based optimizers thanks to the end-to-end differentiability of our framework. Finally, we assess the proposed framework for manipulation tasks with various safety thresholds and demonstrate the feasibility of result trajectories on a surgical robot. The effects of the regularization terms are analyzed in an additional ablation study.

The number of international benchmarking competitions is steadily increasing in various fields of machine learning (ML) research and practice. So far, however, little is known about the common practice as well as bottlenecks faced by the community in tackling the research questions posed. To shed light on the status quo of algorithm development in the specific field of biomedical imaging analysis, we designed an international survey that was issued to all participants of challenges conducted in conjunction with the IEEE ISBI 2021 and MICCAI 2021 conferences (80 competitions in total). The survey covered participants' expertise and working environments, their chosen strategies, as well as algorithm characteristics. A median of 72% challenge participants took part in the survey. According to our results, knowledge exchange was the primary incentive (70%) for participation, while the reception of prize money played only a minor role (16%). While a median of 80 working hours was spent on method development, a large portion of participants stated that they did not have enough time for method development (32%). 25% perceived the infrastructure to be a bottleneck. Overall, 94% of all solutions were deep learning-based. Of these, 84% were based on standard architectures. 43% of the respondents reported that the data samples (e.g., images) were too large to be processed at once. This was most commonly addressed by patch-based training (69%), downsampling (37%), and solving 3D analysis tasks as a series of 2D tasks. K-fold cross-validation on the training set was performed by only 37% of the participants and only 50% of the participants performed ensembling based on multiple identical models (61%) or heterogeneous models (39%). 48% of the respondents applied postprocessing steps.

Deformable Image Registration (DIR) plays a significant role in quantifying deformation in medical data. Recent Deep Learning methods have shown promising accuracy and speedup for registering a pair of medical images. However, in 4D (3D + time) medical data, organ motion, such as respiratory motion and heart beating, can not be effectively modeled by pair-wise methods as they were optimized for image pairs but did not consider the organ motion patterns necessary when considering 4D data. This paper presents ORRN, an Ordinary Differential Equations (ODE)-based recursive image registration network. Our network learns to estimate time-varying voxel velocities for an ODE that models deformation in 4D image data. It adopts a recursive registration strategy to progressively estimate a deformation field through ODE integration of voxel velocities. We evaluate the proposed method on two publicly available lung 4DCT datasets, DIRLab and CREATIS, for two tasks: 1) registering all images to the extreme inhale image for 3D+t deformation tracking and 2) registering extreme exhale to inhale phase images. Our method outperforms other learning-based methods in both tasks, producing the smallest Target Registration Error of 1.24mm and 1.26mm, respectively. Additionally, it produces less than 0.001\% unrealistic image folding, and the computation speed is less than 1 second for each CT volume. ORRN demonstrates promising registration accuracy, deformation plausibility, and computation efficiency on group-wise and pair-wise registration tasks. It has significant implications in enabling fast and accurate respiratory motion estimation for treatment planning in radiation therapy or robot motion planning in thoracic needle insertion.