In this work, we propose CleanMel, a single-channel Mel-spectrogram denoising and dereverberation network for improving both speech quality and automatic speech recognition (ASR) performance. The proposed network takes as input the noisy and reverberant microphone recording and predicts the corresponding clean Mel-spectrogram. The enhanced Mel-spectrogram can be either transformed to speech waveform with a neural vocoder or directly used for ASR. The proposed network is composed of interleaved cross-band and narrow-band processing in the Mel-frequency domain, for learning the full-band spectral pattern and the narrow-band properties of signals, respectively. Compared to linear-frequency domain or time-domain speech enhancement, the key advantage of Mel-spectrogram enhancement is that Mel-frequency presents speech in a more compact way and thus is easier to learn, which will benefit both speech quality and ASR. Experimental results on four English and one Chinese datasets demonstrate a significant improvement in both speech quality and ASR performance achieved by the proposed model. Code and audio examples of our model are available online in https://audio.westlake.edu.cn/Research/CleanMel.html.

The interactions between DNA, RNA, and proteins are fundamental to biological processes, as illustrated by the central dogma of molecular biology. While modern biological pre-trained models have achieved great success in analyzing these macromolecules individually, their interconnected nature remains under-explored. In this paper, we follow the guidance of the central dogma to redesign both the data and model pipeline and offer a comprehensive framework, Life-Code, that spans different biological functions. As for data flow, we propose a unified pipeline to integrate multi-omics data by reverse-transcribing RNA and reverse-translating amino acids into nucleotide-based sequences. As for the model, we design a codon tokenizer and a hybrid long-sequence architecture to encode the interactions of both coding and non-coding regions with masked modeling pre-training. To model the translation and folding process with coding sequences, Life-Code learns protein structures of the corresponding amino acids by knowledge distillation from off-the-shelf protein language models. Such designs enable Life-Code to capture complex interactions within genetic sequences, providing a more comprehensive understanding of multi-omics with the central dogma. Extensive Experiments show that Life-Code achieves state-of-the-art performance on various tasks across three omics, highlighting its potential for advancing multi-omics analysis and interpretation.

Electrocardiogram (ECG) analysis is a fundamental tool for diagnosing cardiovascular conditions, yet anomaly detection in ECG signals remains challenging due to their inherent complexity and variability. We propose Multi-scale Masked Autoencoder for ECG anomaly detection (MMAE-ECG), a novel end-to-end framework that effectively captures both global and local dependencies in ECG data. Unlike state-of-the-art methods that rely on heartbeat segmentation or R-peak detection, MMAE-ECG eliminates the need for such pre-processing steps, enhancing its suitability for clinical deployment. MMAE-ECG partitions ECG signals into non-overlapping segments, with each segment assigned learnable positional embeddings. A novel multi-scale masking strategy and multi-scale attention mechanism, along with distinct positional embeddings, enable a lightweight Transformer encoder to effectively capture both local and global dependencies. The masked segments are then reconstructed using a single-layer Transformer block, with an aggregation strategy employed during inference to refine the outputs. Experimental results demonstrate that our method achieves performance comparable to state-of-the-art approaches while significantly reducing computational complexity-approximately 1/78 of the floating-point operations (FLOPs) required for inference. Ablation studies further validate the effectiveness of each component, highlighting the potential of multi-scale masked autoencoders for anomaly detection.

The efficacy of large language models (LLMs) on downstream tasks usually hinges on instruction tuning, which relies critically on the quality of training data. Unfortunately, collecting high-quality and diverse data is both expensive and time-consuming. To mitigate this issue, we propose a novel Star-Agents framework, which automates the enhancement of data quality across datasets through multi-agent collaboration and assessment. The framework adopts a three-pronged strategy. It initially generates diverse instruction data with multiple LLM agents through a bespoke sampling method. Subsequently, the generated data undergo a rigorous evaluation using a dual-model method that assesses both difficulty and quality. Finaly, the above process evolves in a dynamic refinement phase, where more effective LLMs are prioritized, enhancing the overall data quality. Our empirical studies, including instruction tuning experiments with models such as Pythia and LLaMA, demonstrate the effectiveness of the proposed framework. Optimized datasets have achieved substantial improvements, with an average increase of 12% and notable gains in specific metrics, such as a 40% improvement in Fermi, as evidenced by benchmarks like MT-bench, Vicuna bench, and WizardLM testset.

Safe control is of great importance in online decision making for robot learning through filtering out unsafe explorative actions [1, 2, 3, 4], guaranteeing safety during sim-to-real transfer in a hierarchical manner [5]. As an effective tool of safe control, control barrier functions (CBFs) have been studied for years on both verification and synthesis [6, 7, 8, 9, 10]. A valid CBF guarantees safety by ensuring the function values non-positive for any states along the safe trajectory, implicitly enforcing the non-trivial forward invariance that feasible control inputs always exist to maintain the following non-positive energy values once the state is safe. To ensure forward invariance, polynomial-based CBFs have been proposed based on hand-crafted parametric functions [11, 12, 13], which can be verified through algebraic geometry techniques like sum-of-squares (SOS) optimization [14, 15, 16]. However, polynomial-based CBFs cannot encode complicated safety constraints [17], and the generic parameterization of non-conservative safe control for various nonlinear dynamics and nonconvex safety specifications is needed. Neural network parameterized CBFs (neural CBFs) have shown promising results due to their powerful expressiveness in modeling complex dynamics with bounded control inputs [18, 19, 20, 21, 22]. But it is challenging to guarantee that the learned neural CBF is valid because of its poor mathematical interpretability. One way to ensure the safety/stability of the dynamic system is to learn neural barrier/Lyapunov certificates [23, 24, 25, 26, 27, 28], but it may be too conservative and cause false negatives if the formal verification only relies on a specific control policy [17, 29]. Recent works to directly verify the forward invariance of learned neural CBFs are based on SMT-based counterexample falsification [30, 31], mixed integer programming [32], Lipschitz neural networks [33], and CROWN-based linear bound propagation [34, 35, 36].

Large language models (LLMs) face a daunting challenge due to the excessive computational and memory requirements of the commonly used Transformer architecture. While state space model (SSM) is a new type of foundational network architecture offering lower computational complexity, their performance has yet to fully rival that of Transformers. This paper introduces DenseSSM, a novel approach to enhance the flow of hidden information between layers in SSMs. By selectively integrating shallowlayer hidden states into deeper layers, DenseSSM retains fine-grained information crucial for the final output. Dense connections enhanced DenseSSM still maintains the training parallelizability and inference efficiency. The proposed method can be widely applicable to various SSM types like RetNet and Mamba. With similar model size, DenseSSM achieves significant improvements, exemplified by DenseRetNet outperforming the original RetNet with up to 5% accuracy improvement on public benchmarks. code is avalaible at https://github.com/WailordHe/DenseSSM

Safe offline reinforcement learning is a promising way to bypass risky online interactions towards safe policy learning. Most existing methods only enforce soft constraints, i.e., constraining safety violations in expectation below thresholds predetermined. This can lead to potentially unsafe outcomes, thus unacceptable in safety-critical scenarios. An alternative is to enforce the hard constraint of zero violation. However, this can be challenging in offline setting, as it needs to strike the right balance among three highly intricate and correlated aspects: safety constraint satisfaction, reward maximization, and behavior regularization imposed by offline datasets. Interestingly, we discover that via reachability analysis of safe-control theory, the hard safety constraint can be equivalently translated to identifying the largest feasible region given the offline dataset. This seamlessly converts the original trilogy problem to a feasibility-dependent objective, i.e., maximizing reward value within the feasible region while minimizing safety risks in the infeasible region. Inspired by these, we propose FISOR (FeasIbility-guided Safe Offline RL), which allows safety constraint adherence, reward maximization, and offline policy learning to be realized via three decoupled processes, while offering strong safety performance and stability. In FISOR, the optimal policy for the translated optimization problem can be derived in a special form of weighted behavior cloning, which can be effectively extracted with a guided diffusion model thanks to its expressiveness. Moreover, we propose a novel energy-guided sampling method that does not require training a complicated time-dependent classifier to simplify the training. Evaluation results show that FISOR is the only method that can guarantee safety satisfaction in all tasks, while achieving top returns in most tasks. Autonomous decision making imposes paramount safety concerns in safety-critical tasks (Li, 2023), such as industrial control systems (Zhan et al., 2022) and autonomous driving (Kiran et al., 2021), where any unsafe outcome can lead to severe consequences.

Reinforcement learning (RL) agents are vulnerable to adversarial disturbances, which can deteriorate task performance or compromise safety specifications. Existing methods either address safety requirements under the assumption of no adversary (e.g., safe RL) or only focus on robustness against performance adversaries (e.g., robust RL). Learning one policy that is both safe and robust remains a challenging open problem. The difficulty is how to tackle two intertwined aspects in the worst cases: feasibility and optimality. Optimality is only valid inside a feasible region, while identification of maximal feasible region must rely on learning the optimal policy. To address this issue, we propose a systematic framework to unify safe RL and robust RL, including problem formulation, iteration scheme, convergence analysis and practical algorithm design. This unification is built upon constrained two-player zero-sum Markov games. A dual policy iteration scheme is proposed, which simultaneously optimizes a task policy and a safety policy. The convergence of this iteration scheme is proved. Furthermore, we design a deep RL algorithm for practical implementation, called dually robust actor-critic (DRAC). The evaluations with safety-critical benchmarks demonstrate that DRAC achieves high performance and persistent safety under all scenarios (no adversary, safety adversary, performance adversary), outperforming all baselines significantly.

Recently, Neural Radiance Field (NeRF) has shown great success in rendering novel-view images of a given scene by learning an implicit representation with only posed RGB images. NeRF and relevant neural field methods (e.g., neural surface representation) typically optimize a point-wise loss and make point-wise predictions, where one data point corresponds to one pixel. Unfortunately, this line of research failed to use the collective supervision of distant pixels, although it is known that pixels in an image or scene can provide rich structural information. To the best of our knowledge, we are the first to design a nonlocal multiplex training paradigm for NeRF and relevant neural field methods via a novel Stochastic Structural SIMilarity (S3IM) loss that processes multiple data points as a whole set instead of process multiple inputs independently. Our extensive experiments demonstrate the unreasonable effectiveness of S3IM in improving NeRF and neural surface representation for nearly free. The improvements of quality metrics can be particularly significant for those relatively difficult tasks: e.g., the test MSE loss unexpectedly drops by more than 90% for TensoRF and DVGO over eight novel view synthesis tasks; a 198% F-score gain and a 64% Chamfer $L_{1}$ distance reduction for NeuS over eight surface reconstruction tasks. Moreover, S3IM is consistently robust even with sparse inputs, corrupted images, and dynamic scenes.

Safe reinforcement learning (RL) aims to solve an optimal control problem under safety constraints. Existing $\textit{direct}$ safe RL methods use the original constraint throughout the learning process. They either lack theoretical guarantees of the policy during iteration or suffer from infeasibility problems. To address this issue, we propose an $\textit{indirect}$ safe RL method called feasible policy iteration (FPI) that iteratively uses the feasible region of the last policy to constrain the current policy. The feasible region is represented by a feasibility function called constraint decay function (CDF). The core of FPI is a region-wise policy update rule called feasible policy improvement, which maximizes the return under the constraint of the CDF inside the feasible region and minimizes the CDF outside the feasible region. This update rule is always feasible and ensures that the feasible region monotonically expands and the state-value function monotonically increases inside the feasible region. Using the feasible Bellman equation, we prove that FPI converges to the maximum feasible region and the optimal state-value function. Experiments on classic control tasks and Safety Gym show that our algorithms achieve lower constraint violations and comparable or higher performance than the baselines.