Pediatric sleep is an important but often overlooked area in health informatics. We present PedSleepMAE, a generative model that fully leverages multimodal pediatric sleep signals including multichannel EEGs, respiratory signals, EOGs and EMG. This masked autoencoder-based model performs comparably to supervised learning models in sleep scoring and in the detection of apnea, hypopnea, EEG arousal and oxygen desaturation. Its embeddings are also shown to capture subtle differences in sleep signals coming from a rare genetic disorder. Furthermore, PedSleepMAE generates realistic signals that can be used for sleep segment retrieval, outlier detection, and missing channel imputation. This is the first general-purpose generative model trained on multiple types of pediatric sleep signals.

Electrocardiogram (ECG) interpretation requires specialized expertise, often involving synthesizing insights from ECG signals with complex clinical queries posed in natural language. The scarcity of labeled ECG data coupled with the diverse nature of clinical inquiries presents a significant challenge for developing robust and adaptable ECG diagnostic systems. This work introduces a novel multimodal meta-learning method for few-shot ECG question answering, addressing the challenge of limited labeled data while leveraging the rich knowledge encoded within large language models (LLMs). Our LLM-agnostic approach integrates a pre-trained ECG encoder with a frozen LLM (e.g., LLaMA and Gemma) via a trainable fusion module, enabling the language model to reason about ECG data and generate clinically meaningful answers. Extensive experiments demonstrate superior generalization to unseen diagnostic tasks compared to supervised baselines, achieving notable performance even with limited ECG leads. For instance, in a 5-way 5-shot setting, our method using LLaMA-3.1-8B achieves accuracy of 84.6%, 77.3%, and 69.6% on single verify, choose and query question types, respectively. These results highlight the potential of our method to enhance clinical ECG interpretation by combining signal processing with the nuanced language understanding capabilities of LLMs, particularly in data-constrained scenarios.

The high incidence and mortality rates associated with respiratory diseases underscores the importance of early screening. Machine learning models can automate clinical consultations and auscultation, offering vital support in this area. However, the data involved, spanning demographics, medical history, symptoms, and respiratory audio, are heterogeneous and complex. Existing approaches are insufficient and lack generalizability, as they typically rely on limited training data, basic fusion techniques, and task-specific models. In this paper, we propose RespLLM, a novel multimodal large language model (LLM) framework that unifies text and audio representations for respiratory health prediction. RespLLM leverages the extensive prior knowledge of pretrained LLMs and enables effective audio-text fusion through cross-modal attentions. Instruction tuning is employed to integrate diverse data from multiple sources, ensuring generalizability and versatility of the model. Experiments on five real-world datasets demonstrate that RespLLM outperforms leading baselines by an average of 4.6% on trained tasks, 7.9% on unseen datasets, and facilitates zero-shot predictions for new tasks. Our work lays the foundation for multimodal models that can perceive, listen to, and understand heterogeneous data, paving the way for scalable respiratory health diagnosis.

Accurate interpretation of Electrocardiogram (ECG) signals is pivotal for diagnosing cardiovascular diseases. Integrating ECG signals with their accompanying textual reports holds immense potential to enhance clinical diagnostics through the combination of physiological data and qualitative insights. However, this integration faces significant challenges due to inherent modality disparities and the scarcity of labeled data for robust cross-modal learning. To address these obstacles, we propose C-MELT, a novel framework that pre-trains ECG and text data using a contrastive masked auto-encoder architecture. C-MELT uniquely combines the strengths of generative with enhanced discriminative capabilities to achieve robust cross-modal representations. This is accomplished through masked modality modeling, specialized loss functions, and an improved negative sampling strategy tailored for cross-modal alignment. Extensive experiments on five public datasets across diverse downstream tasks demonstrate that C-MELT significantly outperforms existing methods, achieving 15% and 2% increases in linear probing and zero-shot performance over state-of-the-art models, respectively. These results highlight the effectiveness of C-MELT, underscoring its potential to advance automated clinical diagnostics through multi-modal representations. Electrocardiograms (ECGs), obtained through non-invasive electrode placement, provide a critical window into the heart's electrical activity by measuring voltage differences across specific anatomical regions. The standard 12-lead ECG, which captures unique electrical potential differences from each lead, plays a vital role in diagnosing a wide spectrum of cardiac conditions, like arrhythmias. In recent years, significant progress has been made in leveraging deep learning techniques for automated ECG interpretation (Yan et al., 2019; Ebrahimi et al., 2020; Siontis et al., 2021).

Federated Learning (FL) enables multiple machines to collaboratively train a machine learning model without sharing of private training data. Yet, especially for heterogeneous models, a key bottleneck remains the transfer of knowledge gained from each client model with the server. One popular method, FedDF, uses distillation to tackle this task with the use of a common, shared dataset on which predictions are exchanged. However, in many contexts such a dataset might be difficult to acquire due to privacy and the clients might not allow for storage of a large shared dataset. To this end, in this paper, we introduce a new method that improves this knowledge distillation method to only rely on a single shared image between clients and server. In particular, we propose a novel adaptive dataset pruning algorithm that selects the most informative crops generated from only a single image. With this, we show that federated learning with distillation under a limited shared dataset budget works better by using a single image compared to multiple individual ones. Finally, we extend our approach to allow for training heterogeneous client architectures by incorporating a non-uniform distillation schedule and client-model mirroring on the server side.

Federated Learning (FL) is a promising technique for the collaborative training of deep neural networks across multiple devices while preserving data privacy. Despite its potential benefits, FL is hindered by excessive communication costs due to repeated server-client communication during training. To address this challenge, model compression techniques, such as sparsification and weight clustering are applied, which often require modifying the underlying model aggregation schemes or involve cumbersome hyperparameter tuning, with the latter not only adjusts the model's compression rate but also limits model's potential for continuous improvement over growing data. In this paper, we propose FedCompress, a novel approach that combines dynamic weight clustering and server-side knowledge distillation to reduce communication costs while learning highly generalizable models. Through a comprehensive evaluation on diverse public datasets, we demonstrate the efficacy of our approach compared to baselines in terms of communication costs and inference speed. We will make our implementation public upon acceptance.

Wearable technologies enable continuous monitoring of various health metrics, such as physical activity, heart rate, sleep, and stress levels. A key challenge with wearable data is obtaining quality labels. Unlike modalities like video where the videos themselves can be effectively used to label objects or events, wearable data do not contain obvious cues about the physical manifestation of the users and usually require rich metadata. As a result, label noise can become an increasingly thorny issue when labeling such data. In this paper, we propose a novel solution to address noisy label learning, entitled Few-Shot Human-in-the-Loop Refinement (FHLR). Our method initially learns a seed model using weak labels. Next, it fine-tunes the seed model using a handful of expert corrections. Finally, it achieves better generalizability and robustness by merging the seed and fine-tuned models via weighted parameter averaging. We evaluate our approach on four challenging tasks and datasets, and compare it against eight competitive baselines designed to deal with noisy labels. We show that FHLR achieves significantly better performance when learning from noisy labels and achieves state-of-the-art by a large margin, with up to 19% accuracy improvement under symmetric and asymmetric noise. Notably, we find that FHLR is particularly robust to increased label noise, unlike prior works that suffer from severe performance degradation. Our work not only achieves better generalization in high-stakes health sensing benchmarks but also sheds light on how noise affects commonly-used models.

This work introduces BRILLsson, a novel binary neural network-based representation learning model for a broad range of non-semantic speech tasks. We train the model with knowledge distillation from a large and real-valued TRILLsson model with only a fraction of the dataset used to train TRILLsson. The resulting BRILLsson models are only 2MB in size with a latency less than 8ms, making them suitable for deployment in low-resource devices such as wearables. We evaluate BRILLsson on eight benchmark tasks (including but not limited to spoken language identification, emotion recognition, health condition diagnosis, and keyword spotting), and demonstrate that our proposed ultra-light and low-latency models perform as well as large-scale models.

Foundation Models (FMs) have revolutionized machine learning with their adaptability and high performance across tasks; yet, their integration into Federated Learning (FL) is challenging due to substantial communication overhead from their extensive parameterization. Current communication-efficient FL strategies, such as gradient compression, reduce bitrates to around $1$ bit-per-parameter (bpp). However, these approaches fail to harness the characteristics of FMs, with their large number of parameters still posing a challenge to communication efficiency, even at these bitrate regimes. In this work, we present DeltaMask, a novel method that efficiently fine-tunes FMs in FL at an ultra-low bitrate, well below 1 bpp. DeltaMask employs stochastic masking to detect highly effective subnetworks within FMs and leverage stochasticity and sparsity in client masks to compress updates into a compact grayscale image using probabilistic filters, deviating from traditional weight training approaches. Our comprehensive evaluations across various datasets and architectures demonstrate DeltaMask efficiently achieves bitrates as low as 0.09 bpp, enhancing communication efficiency while maintaining FMs performance, as measured on 8 datasets and 5 pre-trained models of various network architectures.

Federated Learning (FL) is a distributed machine learning paradigm that enables learning models from decentralized private datasets, where the labeling effort is entrusted to the clients. While most existing FL approaches assume high-quality labels are readily available on users' devices; in reality, label noise can naturally occur in FL and is closely related to clients' characteristics. Due to scarcity of available data and significant label noise variations among clients in FL, existing state-of-the-art centralized approaches exhibit unsatisfactory performance, while prior FL studies rely on excessive on-device computational schemes or additional clean data available on server. Here, we propose FedLN, a framework to deal with label noise across different FL training stages; namely, FL initialization, on-device model training, and server model aggregation, able to accommodate the diverse computational capabilities of devices in a FL system. Specifically, FedLN computes per-client noise-level estimation in a single federated round and improves the models' performance by either correcting or mitigating the effect of noisy samples. Our evaluation on various publicly available vision and audio datasets demonstrate a 22% improvement on average compared to other existing methods for a label noise level of 60%. We further validate the efficiency of FedLN in human-annotated real-world noisy datasets and report a 4.8% increase on average in models' recognition performance, highlighting that~\method~can be useful for improving FL services provided to everyday users.