Chronic kidney disease (CKD) is a major global health issue, affecting over 10% of the population and causing significant mortality. While kidney biopsy remains the gold standard for CKD diagnosis and treatment, the lack of comprehensive benchmarks for kidney pathology segmentation hinders progress in the field. To address this, we organized the Kidney Pathology Image Segmentation (KPIs) Challenge, introducing a dataset that incorporates preclinical rodent models of CKD with over 10,000 annotated glomeruli from 60+ Periodic Acid Schiff (PAS)-stained whole slide images. The challenge includes two tasks, patch-level segmentation and whole slide image segmentation and detection, evaluated using the Dice Similarity Coefficient (DSC) and F1-score. By encouraging innovative segmentation methods that adapt to diverse CKD models and tissue conditions, the KPIs Challenge aims to advance kidney pathology analysis, establish new benchmarks, and enable precise, large-scale quantification for disease research and diagnosis.

Abstract--Legged locomotion has recently achieved remarkable success with the progress of machine learning techniques, especially deep reinforcement learning (RL). Controllers employing neural networks have demonstrated empirical and qualitative robustness against real-world uncertainties, including sensor noise and external perturbations. However, formally investigating the vulnerabilities of these locomotion controllers remains a challenge. This difficulty arises from the requirement to pinpoint vulnerabilities across a long-tailed distribution within a highdimensional, temporally sequential space. As a first step towards quantitative verification, we propose a computational method that leverages sequential adversarial attacks to identify weaknesses in learned locomotion controllers. Our research demonstrates that, even state-of-the-art robust controllers can fail significantly under well-designed, low-magnitude adversarial sequence. Through experiments in simulation and on the real robot, we validate our approach's effectiveness, and we illustrate how the results it generates can be used to robustify the original policy and offer valuable insights into the safety of these black-box policies.

Autonomous wheeled-legged robots have the potential to transform logistics systems, improving operational efficiency and adaptability in urban environments. Navigating urban environments, however, poses unique challenges for robots, necessitating innovative solutions for locomotion and navigation. These challenges include the need for adaptive locomotion across varied terrains and the ability to navigate efficiently around complex dynamic obstacles. This work introduces a fully integrated system comprising adaptive locomotion control, mobility-aware local navigation planning, and large-scale path planning within the city. Using model-free reinforcement learning (RL) techniques and privileged learning, we develop a versatile locomotion controller. This controller achieves efficient and robust locomotion over various rough terrains, facilitated by smooth transitions between walking and driving modes. It is tightly integrated with a learned navigation controller through a hierarchical RL framework, enabling effective navigation through challenging terrain and various obstacles at high speed. Our controllers are integrated into a large-scale urban navigation system and validated by autonomous, kilometer-scale navigation missions conducted in Zurich, Switzerland, and Seville, Spain. These missions demonstrate the system's robustness and adaptability, underscoring the importance of integrated control systems in achieving seamless navigation in complex environments. Our findings support the feasibility of wheeled-legged robots and hierarchical RL for autonomous navigation, with implications for last-mile delivery and beyond.

Legged robots have the potential to traverse complex terrain and access confined spaces beyond the reach of traditional platforms thanks to their ability to carefully select footholds and flexibly adapt their body posture while walking. However, robust deployment in real-world applications is still an open challenge. In this paper, we present a method for legged locomotion control using reinforcement learning and 3D volumetric representations to enable robust and versatile locomotion in confined and unstructured environments. By employing a two-layer hierarchical policy structure, we exploit the capabilities of a highly robust low-level policy to follow 6D commands and a high-level policy to enable three-dimensional spatial awareness for navigating under overhanging obstacles. Our study includes the development of a procedural terrain generator to create diverse training environments. We present a series of experimental evaluations in both simulation and real-world settings, demonstrating the effectiveness of our approach in controlling a quadruped robot in confined, rough terrain. By achieving this, our work extends the applicability of legged robots to a broader range of scenarios.

Abstract--Challenges in real-world robotic applications often stem from managing multiple, dynamically varying entities such as neighboring robots, manipulable objects, and navigation goals. Existing multi-agent control strategies face scalability limitations, struggling to handle arbitrary numbers of entities. Additionally, they often rely on engineered heuristics for assigning entities among agents. We propose a data driven approach to address these limitations by introducing a decentralized control system using neural network policies trained in simulation. Leveraging permutation invariant neural network architectures and modelfree reinforcement learning, our approach allows control agents to autonomously determine the relative importance of different entities without being biased by ordering or limited by a fixed capacity. We prove the effectiveness of our architectural choice through experiments with three exemplary multi-entity problems. Our analysis underscores the pivotal role of the end-to-end trained permutation invariant encoders in achieving scalability and improving the task performance in multi-object manipulation or multi-goal navigation problems. Multi-entity problems studied in this work. For example, human workers collaborate with problem where robots are given multiple navigation goals, co-workers to construct structures, or a group of friends Figure 1B illustrates box packing problem where robots have splits up to find various products in a grocery store.

Shifting from traditional control strategies to Deep Reinforcement Learning (RL) for legged robots poses inherent challenges, especially when addressing real-world physical constraints during training. While high-fidelity simulations provide significant benefits, they often bypass these essential physical limitations. In this paper, we experiment with the Constrained Markov Decision Process (CMDP) framework instead of the conventional unconstrained RL for robotic applications. We perform a comparative study of different constrained policy optimization algorithms to identify suitable methods for practical implementation. Our robot experiments demonstrate the critical role of incorporating physical constraints, yielding successful sim-to-real transfers, and reducing operational errors on physical systems. The CMDP formulation streamlines the training process by separately handling constraints from rewards. Our findings underscore the potential of constrained RL for the effective development and deployment of learned controllers in robotics.

Mobile ground robots require perceiving and understanding their surrounding support surface to move around autonomously and safely. The support surface is commonly estimated based on exteroceptive depth measurements, e.g., from LiDARs. However, the measured depth fails to align with the true support surface in the presence of high grass or other penetrable vegetation. In this work, we present the Semantic Pointcloud Filter (SPF), a Convolutional Neural Network (CNN) that learns to adjust LiDAR measurements to align with the underlying support surface. The SPF is trained in a semi-self-supervised manner and takes as an input a LiDAR pointcloud and RGB image. The network predicts a binary segmentation mask that identifies the specific points requiring adjustment, along with estimating their corresponding depth values. To train the segmentation task, 300 distinct images are manually labeled into rigid and non-rigid terrain. The depth estimation task is trained in a self-supervised manner by utilizing the future footholds of the robot to estimate the support surface based on a Gaussian process. Our method can correctly adjust the support surface prior to interacting with the terrain and is extensively tested on the quadruped robot ANYmal. We show the qualitative benefits of SPF in natural environments for elevation mapping and traversability estimation compared to using raw sensor measurements and existing smoothing methods. Quantitative analysis is performed in various natural environments, and an improvement by 48% RMSE is achieved within a meadow terrain.

Parallel-elastic joints can improve the efficiency and strength of robots by assisting the actuators with additional torques. For these benefits to be realized, a spring needs to be carefully designed. However, designing robots is an iterative and tedious process, often relying on intuition and heuristics. We introduce a design optimization framework that allows us to co-optimize a parallel elastic knee joint and locomotion controller for quadrupedal robots with minimal human intuition. We design a parallel elastic joint and optimize its parameters with respect to the efficiency in a model-free fashion. In the first step, we train a design-conditioned policy using model-free Reinforcement Learning, capable of controlling the quadruped in the predefined range of design parameters. Afterwards, we use Bayesian Optimization to find the best design using the policy. We use this framework to optimize the parallel-elastic spring parameters for the knee of our quadrupedal robot ANYmal together with the optimal controller. We evaluate the optimized design and controller in real-world experiments over various terrains. Our results show that the new system improves the torque-square efficiency of the robot by 33% compared to the baseline and reduces maximum joint torque by 30% without compromising tracking performance. The improved design resulted in 11% longer operation time on flat terrain.

The process of robot design is a complex task and the majority of design decisions are still based on human intuition or tedious manual tuning. A more informed way of facing this task is computational design methods where design parameters are concurrently optimized with corresponding controllers. Existing approaches, however, are strongly influenced by predefined control rules or motion templates and cannot provide end-to-end solutions. In this paper, we present a design optimization framework using model-free meta reinforcement learning, and its application to the optimizing kinematics and actuator parameters of quadrupedal robots. We use meta reinforcement learning to train a locomotion policy that can quickly adapt to different designs. This policy is used to evaluate each design instance during the design optimization. We demonstrate that the policy can control robots of different designs to track random velocity commands over various rough terrains. With controlled experiments, we show that the meta policy achieves close-to-optimal performance for each design instance after adaptation. Lastly, we compare our results against a model-based baseline and show that our approach allows higher performance while not being constrained by predefined motions or gait patterns.

Legged robots pose one of the greatest challenges in robotics. Dynamic and agile maneuvers of animals cannot be imitated by existing methods that are crafted by humans. A compelling alternative is reinforcement learning, which requires minimal craftsmanship and promotes the natural evolution of a control policy. However, so far, reinforcement learning research for legged robots is mainly limited to simulation, and only few and comparably simple examples have been deployed on real systems. The primary reason is that training with real robots, particularly with dynamically balancing systems, is complicated and expensive. In the present work, we introduce a method for training a neural network policy in simulation and transferring it to a state-of-the-art legged system, thereby leveraging fast, automated, and cost-effective data generation schemes. The approach is applied to the ANYmal robot, a sophisticated medium-dog-sized quadrupedal system. Using policies trained in simulation, the quadrupedal machine achieves locomotion skills that go beyond what had been achieved with prior methods: ANYmal is capable of precisely and energy-efficiently following high-level body velocity commands, running faster than before, and recovering from falling even in complex configurations.