Multivariate cortico-muscular analysis has recently emerged as a promising approach for evaluating the corticospinal neural pathway. However, current multivariate approaches encounter challenges such as high dimensionality and limited sample sizes, thus restricting their further applications. In this paper, we propose a structured and sparse partial least squares coherence algorithm (ssPLSC) to extract shared latent space representations related to cortico-muscular interactions. Our approach leverages an embedded optimization framework by integrating a partial least squares (PLS)-based objective function, a sparsity constraint and a connectivity-based structured constraint, addressing the generalizability, interpretability and spatial structure. To solve the optimization problem, we develop an efficient alternating iterative algorithm within a unified framework and prove its convergence experimentally. Extensive experimental results from one synthetic and several real-world datasets have demonstrated that ssPLSC can achieve competitive or better performance over some representative multivariate cortico-muscular fusion methods, particularly in scenarios characterized by limited sample sizes and high noise levels. This study provides a novel multivariate fusion method for cortico-muscular analysis, offering a transformative tool for the evaluation of corticospinal pathway integrity in neurological disorders.

Time-series forecasting has gained significant attention in machine learning due to its crucial role in various domains. However, most existing forecasting models rely heavily on point-wise loss functions like Mean Square Error, which treat each time step independently and neglect the structural dependencies inherent in time series data, making it challenging to capture complex temporal patterns accurately. To address these challenges, we propose a novel Patch-wise Structural (PS) loss, designed to enhance structural alignment by comparing time series at the patch level. Through leveraging local statistical properties, such as correlation, variance, and mean, PS loss captures nuanced structural discrepancies overlooked by traditional point-wise losses. Furthermore, it integrates seamlessly with point-wise loss, simultaneously addressing local structural inconsistencies and individual time-step errors. PS loss establishes a novel benchmark for accurately modeling complex time series data and provides a new perspective on time series loss function design. Extensive experiments demonstrate that PS loss significantly improves the performance of state-of-the-art models across diverse real-world datasets.

--With the rapid advent of generative models, efficiently deploying these models on specialized hardware has become critical. T ensor Processing Units (TPUs) are designed to accelerate AI workloads, but their high power consumption necessitates innovations for improving efficiency. Compute-in-memory (CIM) has emerged as a promising paradigm with superior area and energy efficiency. In this work, we present a TPU architecture that integrates digital CIM to replace conventional digital systolic arrays in matrix multiply units (MXUs). We first establish a CIM-based TPU architecture model and simulator to evaluate the benefits of CIM for diverse generative model inference. Building upon the observed design insights, we further explore various CIM-based TPU architectural design choices. Up to 44.2% and 33.8% performance improvement for large language model and diffusion transformer inference, and 27.3 reduction in MXU energy consumption can be achieved with different design choices, compared to the baseline TPUv4i architecture. Generative models, such as large language models (LLMs) and diffusion models (DMs), have exhibited exceptional performance in generating content across various modalities. For example, LLMs have dominated NLP tasks, powering applications like ChatGPT [1].

Aligning language models with human preferences is critical for real-world deployment, but existing methods often require large amounts of high-quality human annotations. Aiming at a data-efficient alignment method, we propose Stackelberg Game Preference Optimization (SGPO), a framework that models alignment as a two-player Stackelberg game, where a policy (leader) optimizes against a worst-case preference distribution (follower) within an $\epsilon$-Wasserstein ball, ensuring robustness to (self-)annotation noise and distribution shifts. SGPO guarantees $O(\epsilon)$-bounded regret, unlike Direct Preference Optimization (DPO), which suffers from linear regret growth in the distribution mismatch. We instantiate SGPO with the Stackelberg Self-Annotated Preference Optimization (SSAPO) algorithm, which iteratively self-annotates preferences and adversarially reweights synthetic annotated preferences. Using only 2K seed preferences, from the UltraFeedback dataset, i.e., 1/30 of human labels in the dataset, our method achieves 35.82% GPT-4 win-rate with Mistral-7B and 40.12% with Llama3-8B-Instruct within three rounds of SSAPO.

The cortico-spinal neural pathway is fundamental for motor control and movement execution, and in humans it is typically studied using concurrent electroencephalography (EEG) and electromyography (EMG) recordings. However, current approaches for capturing high-level and contextual connectivity between these recordings have important limitations. Here, we present a novel application of statistical dependence estimators based on orthonormal decomposition of density ratios to model the relationship between cortical and muscle oscillations. Our method extends from traditional scalar-valued measures by learning eigenvalues, eigenfunctions, and projection spaces of density ratios from realizations of the signal, addressing the interpretability, scalability, and local temporal dependence of cortico-muscular connectivity. We experimentally demonstrate that eigenfunctions learned from cortico-muscular connectivity can accurately classify movements and subjects. Moreover, they reveal channel and temporal dependencies that confirm the activation of specific EEG channels during movement. Our code is available at https://github.com/bohu615/corticomuscular-eigen-encoder.

Safety and resilience are critical for autonomous unmanned aerial vehicles (UAVs). We introduce MAVFI, the micro aerial vehicles (MAVs) resilience analysis methodology to assess the effect of silent data corruption (SDC) on UAVs' mission metrics, such as flight time and success rate, for accurately measuring system resilience. To enhance the safety and resilience of robot systems bound by size, weight, and power (SWaP), we offer two low-overhead anomaly-based SDC detection and recovery algorithms based on Gaussian statistical models and autoencoder neural networks. Our anomaly error protection techniques are validated in numerous simulated environments. We demonstrate that the autoencoder-based technique can recover up to all failure cases in our studied scenarios with a computational overhead of no more than 0.0062%. Our application-aware resilience analysis framework, MAVFI, can be utilized to comprehensively test the resilience of other Robot Operating System (ROS)-based applications and is publicly available at https://github.com/harvard-edge/MAVBench/tree/mavfi.