Video diffusion models (VDMs) facilitate the generation of high-quality videos, with current research predominantly concentrated on scaling efforts during training through improvements in data quality, computational resources, and model complexity. However, inference-time scaling has received less attention, with most approaches restricting models to a single generation attempt. Recent studies have uncovered the existence of "golden noises" that can enhance video quality during generation. Building on this, we find that guiding the scaling inference-time search of VDMs to identify better noise candidates not only evaluates the quality of the frames generated in the current step but also preserves the high-level object features by referencing the anchor frame from previous multi-chunks, thereby delivering long-term value. Our analysis reveals that diffusion models inherently possess flexible adjustments of computation by varying denoising steps, and even a one-step denoising approach, when guided by a reward signal, yields significant long-term benefits. Based on the observation, we proposeScalingNoise, a plug-and-play inference-time search strategy that identifies golden initial noises for the diffusion sampling process to improve global content consistency and visual diversity. Specifically, we perform one-step denoising to convert initial noises into a clip and subsequently evaluate its long-term value, leveraging a reward model anchored by previously generated content. Moreover, to preserve diversity, we sample candidates from a tilted noise distribution that up-weights promising noises. In this way, ScalingNoise significantly reduces noise-induced errors, ensuring more coherent and spatiotemporally consistent video generation. Extensive experiments on benchmark datasets demonstrate that the proposed ScalingNoise effectively improves long video generation.

In recent years, large language models (LLMs) have demonstrated remarkable potential across various medical applications. Building on this foundation, multimodal large language models (MLLMs) integrate LLMs with visual models to process diverse inputs, including clinical data and medical images. In ophthalmology, LLMs have been explored for analyzing optical coherence tomography (OCT) reports, assisting in disease classification, and even predicting treatment outcomes. However, existing MLLM benchmarks often fail to capture the complexities of real-world clinical practice, particularly in the analysis of OCT images. Many suffer from limitations such as small sample sizes, a lack of diverse OCT datasets, and insufficient expert validation. These shortcomings hinder the accurate assessment of MLLMs' ability to interpret OCT scans and their broader applicability in ophthalmology. Our dataset, curated through rigorous quality control and expert annotation, consists of 439 fundus images and 75 OCT images. Using a standardized API-based framework, we assessed seven mainstream MLLMs and observed significant variability in diagnostic accuracy across different diseases. While some models performed well in diagnosing conditions such as diabetic retinopathy and age-related macular degeneration, they struggled with others, including choroidal neovascularization and myopia, highlighting inconsistencies in performance and the need for further refinement. Our findings emphasize the importance of developing clinically relevant benchmarks to provide a more accurate assessment of MLLMs' capabilities. By refining these models and expanding their scope, we can enhance their potential to transform ophthalmic diagnosis and treatment.

Large language models (LLMs) excel in various NLP tasks and modern medicine, but their evaluation in traditional Chinese medicine (TCM) is underexplored. To address this, we introduce TCM3CEval, a benchmark assessing LLMs in TCM across three dimensions: core knowledge mastery, classical text understanding, and clinical decision-making. We evaluate diverse models, including international (e.g., GPT-4o), Chinese (e.g., InternLM), and medical-specific (e.g., PLUSE). Results show a performance hierarchy: all models have limitations in specialized subdomains like Meridian & Acupoint theory and Various TCM Schools, revealing gaps between current capabilities and clinical needs. Models with Chinese linguistic and cultural priors perform better in classical text interpretation and clinical reasoning. TCM-3CEval sets a standard for AI evaluation in TCM, offering insights for optimizing LLMs in culturally grounded medical domains. The benchmark is available on Medbench's TCM track, aiming to assess LLMs' TCM capabilities in basic knowledge, classic texts, and clinical decision-making through multidimensional questions and real cases.

In recent years, large language models (LLMs), empowered by massive text corpora and deep learning techniques, have demonstrated breakthrough advancements in cross-domain knowledge transfer and human-machine dialogue interactions [1]. Within the healthcare domain, LLMs are increasingly deployed across nine core application scenarios, including intelligent diagnosis, personalized treatment, and drug discovery, garnering significant attention from both academia and industry [2, 3]. A particularly important area of focus is the development and evaluation of Chinese medical LLMs, which face unique challenges due to the specialized nature of medical knowledge and the high-stakes implications of clinical decision-making. Hence, ensuring the reliability and safety of these models has become critical, necessitating rigorous evaluation frameworks [4]. Current research on medical LLMs evaluation exhibits two predominant trends. On one hand, general-domain benchmarks (e.g., HELM [5], MMLU [6]) assess foundational model capabilities through medical knowledge tests. On the other hand, specialized medical evaluation systems (e.g., MedQA [7], C-Eval-Medical [8]) emphasize clinical reasoning and ethical compliance. Notably, the MedBench framework [9], jointly developed by institutions including Shanghai AI Laboratory, has emerged as the most influential benchmark for Chinese medical LLMs. By establishing a standardized evaluation system spanning five dimensions--medical language comprehension, complex reasoning, and safety ethics--it has attracted participation from hundreds of research teams.

Medical imaging quality control (QC) is essential for accurate diagnosis, yet traditional QC methods remain labor-intensive and subjective. To address this challenge, in this study, we establish a standardized dataset and evaluation framework for medical imaging QC, systematically assessing large language models (LLMs) in image quality assessment and report standardization. Specifically, we first constructed and anonymized a dataset of 161 chest X-ray (CXR) radiographs and 219 CT reports for evaluation. Then, multiple LLMs, including Gemini 2.0-Flash, GPT-4o, and DeepSeek-R1, were evaluated based on recall, precision, and F1 score to detect technical errors and inconsistencies. Experimental results show that Gemini 2.0-Flash achieved a Macro F1 score of 90 in CXR tasks, demonstrating strong generalization but limited fine-grained performance. DeepSeek-R1 excelled in CT report auditing with a 62.23\% recall rate, outperforming other models. However, its distilled variants performed poorly, while InternLM2.5-7B-chat exhibited the highest additional discovery rate, indicating broader but less precise error detection. These findings highlight the potential of LLMs in medical imaging QC, with DeepSeek-R1 and Gemini 2.0-Flash demonstrating superior performance.

This paper discusses how ophthalmologists often rely on multimodal data to improve diagnostic accuracy. However, complete multimodal data is rare in real-world applications due to a lack of medical equipment and concerns about data privacy. Traditional deep learning methods typically address these issues by learning representations in latent space. However, the paper highlights two key limitations of these approaches: (i) Task-irrelevant redundant information (e.g., numerous slices) in complex modalities leads to significant redundancy in latent space representations. (ii) Overlapping multimodal representations make it difficult to extract unique features for each modality. To overcome these challenges, the authors propose the Essence-Point and Disentangle Representation Learning (EDRL) strategy, which integrates a self-distillation mechanism into an end-to-end framework to enhance feature selection and disentanglement for more robust multimodal learning. Specifically, the Essence-Point Representation Learning module selects discriminative features that improve disease grading performance. The Disentangled Representation Learning module separates multimodal data into modality-common and modality-unique representations, reducing feature entanglement and enhancing both robustness and interpretability in ophthalmic disease diagnosis. Experiments on multimodal ophthalmology datasets show that the proposed EDRL strategy significantly outperforms current state-of-the-art methods.

Recent multimodal large language models (MLLMs) have demonstrated significant potential in open-ended conversation, generating more accurate and personalized responses. However, their abilities to memorize, recall, and reason in sustained interactions within real-world scenarios remain underexplored. This paper introduces MMRC, a Multi-Modal Real-world Conversation benchmark for evaluating six core open-ended abilities of MLLMs: information extraction, multi-turn reasoning, information update, image management, memory recall, and answer refusal. With data collected from real-world scenarios, MMRC comprises 5,120 conversations and 28,720 corresponding manually labeled questions, posing a significant challenge to existing MLLMs. Evaluations on 20 MLLMs in MMRC indicate an accuracy drop during open-ended interactions. We identify four common failure patterns: long-term memory degradation, inadequacies in updating factual knowledge, accumulated assumption of error propagation, and reluctance to say no. To mitigate these issues, we propose a simple yet effective NOTE-TAKING strategy, which can record key information from the conversation and remind the model during its responses, enhancing conversational capabilities. Experiments across six MLLMs demonstrate significant performance improvements.

How can we test AI performance? This question seems trivial, but it isn't. Standard benchmarks often have problems such as in-distribution and small-size test sets, oversimplified metrics, unfair comparisons, and short-term outcome pressure. As a consequence, good performance on standard benchmarks does not guarantee success in real-world scenarios. To address these problems, we present Touchstone, a large-scale collaborative segmentation benchmark of 9 types of abdominal organs. This benchmark is based on 5,195 training CT scans from 76 hospitals around the world and 5,903 testing CT scans from 11 additional hospitals. This diverse test set enhances the statistical significance of benchmark results and rigorously evaluates AI algorithms across various out-of-distribution scenarios. We invited 14 inventors of 19 AI algorithms to train their algorithms, while our team, as a third party, independently evaluated these algorithms on three test sets. In addition, we also evaluated pre-existing AI frameworks--which, differing from algorithms, are more flexible and can support different algorithms--including MONAI from NVIDIA, nnU-Net from DKFZ, and numerous other open-source frameworks. We are committed to expanding this benchmark to encourage more innovation of AI algorithms for the medical domain.

Despite the progress made by multimodal large language models (MLLMs) in computational pathology, they remain limited by a predominant focus on patch-level analysis, missing essential contextual information at the whole-slide level. The lack of large-scale instruction datasets and the gigapixel scale of whole slide images (WSIs) pose significant developmental challenges. In this paper, we present SlideChat, the first vision-language assistant capable of understanding gigapixel whole-slide images, exhibiting excellent multimodal conversational capability and response complex instruction across diverse pathology scenarios. To support its development, we created SlideInstruction, the largest instruction-following dataset for WSIs consisting of 4.2K WSI captions and 176K VQA pairs with multiple categories. Furthermore, we propose SlideBench, a multimodal benchmark that incorporates captioning and VQA tasks to assess SlideChat's capabilities in varied clinical settings such as microscopy, diagnosis. Compared to both general and specialized MLLMs, SlideChat exhibits exceptional capabilities achieving state-of-the-art performance on 18 of 22 tasks. For example, it achieved an overall accuracy of 81.17% on SlideBench-VQA (TCGA), and 54.15% on SlideBench-VQA (BCNB). We will fully release SlideChat, SlideInstruction and SlideBench as open-source resources to facilitate research and development in computational pathology.

Image-text interleaved data, consisting of multiple images and texts arranged in a natural document format, aligns with the presentation paradigm of internet data and closely resembles human reading habits. Recent studies have shown that such data aids multimodal in-context learning and maintains the capabilities of large language models during multimodal fine-tuning. However, the limited scale and diversity of current image-text interleaved data restrict the development of multimodal large language models. In this paper, we introduce OmniCorpus, a 10 billion-level image-text interleaved dataset. Using an efficient data engine, we filter and extract large-scale high-quality documents, which contain 8.6 billion images and 1,696 billion text tokens. Compared to counterparts (e.g., MMC4, OBELICS), our dataset 1) has 15 times larger scales while maintaining good data quality; 2) features more diverse sources, including both English and non-English websites as well as video-centric websites; 3) is more flexible, easily degradable from an image-text interleaved format to pure text corpus and image-text pairs. Through comprehensive analysis and experiments, we validate the quality, usability, and effectiveness of the proposed dataset. We hope this could provide a solid data foundation for future multimodal model research.