tific publications that the biologists

In the first phase of the analysis, I produced a conceptual reconstruc-Peter D. Karp In the next phase, I searched for patterns in the differences between successive My Ph.D. dissertation describes an A class knowledge base defines a tax-states of the biologists' knowledge. Patfocuses on a program of research in process knowledge base describes the terns in the differences indicate reamolecular biology that culminated in chemical reactions that can occur soning methods that were used to the discovery of a new mechanism of between the biological objects in this derive new theories from old ones. An experiment is described My analysis identified theory-modifiuation. In the first phase of my work, in a third knowledge base by creating cation operators that the biologists I performed a historical study of this the particular objects (instantiated used to modify their theories; these program of biological research in from the known classes of objects) operators form the core of the which I reconstructed the different that are present in the experiment. These patterns also supat different points in time and then called Gensim (genetics simulator) port the conjecture that scientists use analyzed the differences between predicts experimental outcomes by four different modes of scientific these successive theories.