Adaptive Treatment Allocation Using Sub-Sampled Gaussian Processes

Personalized medicine targets the customization of treatment strategies to patients' individual characteristics. Here we consider the problem of optimizing personalized pharmacological treatment strategies for cancer. We focus primarily on developing effective strategies to collect the data necessary for the construction of personalized treatments. We formulate this problem as a contextual bandit and present a new algorithm based on repeated sub-sampling for robust data collection in this framework. We present a case study showing experiments on a simulation setting, built from real data collected in a previous animal experiments. Promising results in this case study have since lead us to deploy this strategy in a partner wet lab to allocate treatments for the next phase of animal experiments.