A Computer Simulation of Olfactory Cortex with Functional Implications for Storage and Retrieval of Olfactory Information

A Computer Simulation of Olfactory Cortex With Functional Implications for Storage and Retrieval of Olfactory Information Matthew A. Wilson and James M. Bower Computation and Neural Systems Program Division of Biology, California Institute of Technology, Pasadena, CA 91125 ABSTRACT Based on anatomical and physiological data, we have developed a computer simulation of piriform (olfactory) cortex which is capable of reproducing spatial and temporal patterns of actual cortical activity under a variety of conditions. Using a simple Hebb-type learning rule in conjunction with the cortical dynamics which emerge from the anatomical and physiological organization of the model, the simulations are capable of establishing cortical representations for different input patterns. The basis of these representations lies in the interaction of sparsely distributed, highly divergent/convergent interconnections between modeled neurons. We have shown that different representations can be stored with minimal interference. Further, we have demonstrated that the degree of overlap of cortical representations for different stimuli can also be modulated. Both features are presumably important in classifying olfactory stimuli.