D-VST: Diffusion Transformer for Pathology-Correct Tone-Controllable Cross-Dye Virtual Staining of Whole Slide Images

Diffusion-based virtual staining methods of histopathology images have demonstrated outstanding potential for stain normalization and cross-dye staining (e.g., hematoxylin-eosin to immunohistochemistry). However, achieving pathology-correct cross-dye virtual staining with versatile tone controls poses significantchallenges due to the difficulty of decoupling the given pathology and tone con-ditions.