Statistical Modeling of Cell Assemblies Activities in Associative Cortex of Behaving Monkeys

So far there has been no general method for relating extracellular electrophysiological measured activity of neurons in the associative cortex to underlying network or "cognitive" states. We propose to model such data using a multivariate Poisson Hidden Markov Model. We demonstrate the application of this approach for temporal segmentation of the firing patterns, and for characterization of the cortical responses to external stimuli. Using such a statistical model we can significantly discriminate two behavioral modes of the monkey, and characterize them by the different firing patterns, as well as by the level of coherency of their multi-unit firing activity. Our study utilized measurements carried out on behaving Rhesus monkeys by M. Abeles, E. Vaadia, and H. Bergman, of the Hadassa Medical School of the Hebrew University. 1 Introduction Hebb hypothesized in 1949 that the basic information processing unit in the cortex is a cell-assembly which may include thousands of cells in a highly interconnected network[l].