FromBiasedtoUnbiasedDynamics: AnInfinitesimalGeneratorApproach

Toovercome this bottleneck, data are collected via biased simulations that explore the state space more rapidly. Wepropose aframeworkforlearning frombiased simulations rooted in the infinitesimal generator of the process and the associated resolvent operator. Wecontrast our approach to more common ones based on the transfer operator, showing thatitcanprovably learn thespectral properties oftheunbiased system frombiaseddata.