Reprogramming Matter, Life, and Purpose

Reprogramming matter may sound far-fetched, but we have been doing it with increasing power and staggering efficiency for at least 60 years, and for centuries we have been paving the way toward the ultimate reprogrammed fate of the universe, the vessel of all programs. How will we be doing it in 60 years' time and how will it impact life and the purpose both of machines and of humans?