Machine Learning Applications to Diffuse Reflectance Spectroscopy in Optical Diagnosis; A Systematic Review

Its noninvasive nature and sensitivity to absorption related to tissue biomolecular content and scattering change, associated with subcellular morphology, make it an extremely powerful tool to analyse tissue composition, microstructure or oxygenation status, offering promising performance in applications such as cancer diagnostics and surgical guidance [1, 30, 85, 121]. DRS signals are measured by delivering a typically white light source into the tissue and detecting diffusely reflected signals at a certain distance from the source, where the distance between the emitting and receiving fibres determines the tissue depth probed. Depending on the application and clinical objective, multiple illumination or detection fibres can be used to obtain more quantitative information and probe different depths. The light delivery and collection from tissue are often handled using optical fibres or fibre bundles. When incident on the tissue, the light undergoes scattering and absorption processes, which alter the light intensity across the measured spectrum [75, 121].