Generative Modeling of Hidden Functional Brain Networks

Resting-state functional connectivity fMRI data is a derivative of the unobservable neuronal functional network structure of the human brain. This data is subject to multiple sources of noise such as thermal noise, system noise, and physiological noise. Commonly used methods to infer the latent network structure, such as thresholding methods, make the implicit assumption that weak links are not as important as strong links, and that links are conditionally independent. However, such assumptions provide an incomplete description of the biology. Additionally, despite a core set of observations about functional networks such as smallworldness, modularity, exponentially truncated degree distributions, and presence of various types of hubs, very little is known about the computational principles which can give rise to these observations. This paper presents a Hidden Markov Random Field framework for the purpose of representing, estimating, and evaluating latent neuronal functional relationships using fMRI data. The main theoretical contributions of this paper are summarized as follows.