Toward Continuous Neurocognitive Monitoring: Integrating Speech AI with Relational Graph Transformers for Rare Neurological Diseases

Patients with rare neurological diseases report cognitive symptoms--"brain fog"--invisible to traditional tests. Proof-of-concept in phenylketonuria (PKU) shows speech-derived "Proficiency in Verbal Discourse" correlates Success would transform episodic neurology into continuous personalized monitoring for millions globally. In phenylketonuria (PKU), adults describe "brain fog" and working memory deficits [ We envision smartphone-based speech analysis integrated with medical databases via RELGT, enabling continuous neurocog-nitive monitoring--transforming reactive episodic care into proactive precision neurology. Parkinson's disease involves hypophonia and speech fluctuations tied to medication Huntington's disease reflects CAG-repeat-driven degrneration and progressive motor-cognitive decline. Wilson's disease presents with dysarthria linked to copper accumulation.