Precision disease networks (PDN)

The a rrows represent the frequency of the relationship from A to B i n the cluster of pa tients, R ed arrows repre sente a frequency of 75% or more of the cluster observations containinig the relation ship, green arrows repre sent a frequency in the range 50% - 75%, whereas yellow arrows repre sent repre sent a frequency in the range 25% - 50%. For step 3 we performed a hierarchical cluster analysis using the WARD method that resulted in 10 clust ers for each of the 4 PCA datasets. Figure 2 shows a scatter plot of the first two components of the first of the cluster analysis where the 10 clusters are shown in different colors. In Figure 3 we display the summaries of the 10 clusters. For step 4 we used the cox proportional hazard model with the variable "all death" as response that measures the date of death for any cause of death. We fitted 7 different models using different combinations of predictors as shown on table 1.