Mixture-based Multiple Imputation Model for Clinical Data with a Temporal Dimension

--The problem of missing values in multivariable time series is a key challenge in many applications such as clinical data mining. Although many imputation methods show their effectiveness in many applications, few of them are designed to accommodate clinical multivariable time series. In this work, we propose a multiple imputation model that capture both cross-sectional information and temporal correlations. We integrate Gaussian processes with mixture models and introduce individualized mixing weights to handle the variance of predictive confidence of Gaussian process models. The proposed model is compared with several state-of-the-art imputation algorithms on both real-world and synthetic datasets. Experiments show that our best model can provide more accurate imputation than the benchmarks on all of our datasets. I NTRODUCTION The computational modeling in clinical applications attracts growing interest with the realization that the quantitative understanding of patient pathophysiological progression is crucial to clinical studies [1]. With a comprehensive and precise modeling, we can have a better understanding of a patient's state, offer more precise diagnosis and provide better individualized therapies [2]. Researchers are increasingly motivated to build more accurate computational models from multiple types of clinical data. However, missing values in clinical data challenge researchers using analytic techniques for modeling, as many of the techniques are designed for complete data. Traditional strategies used in clinical studies to handle missing values include deleting records with missing values and imputing missing entries by mean values. However, deleting records with missing values and some other filtering strategies can introduce biases [3] that can impact modeling in many ways, thus limiting its generalizability. Mean imputation is widely used by researchers to handle missing values. However, it is shown to yield less effective estimates than many other modern imputation techniques [4]-[7], such as maximum likelihood approaches and multiple imputation methods (e.g.