Benchmarking of EEG Analysis Techniques for Parkinson's Disease Diagnosis: A Comparison between Traditional ML Methods and Foundation DL Methods

Avola, Danilo, Bernardini, Andrea, Crocetti, Giancarlo, Ladogana, Andrea, Lezoche, Mario, Mancini, Maurizio, Pannone, Daniele, Ranaldi, Amedeo

arXiv.org Artificial Intelligence 

Parkinson's Disease (PD) is a progressive neurodegen-erative disorder that affects motor and cognitive functions, with early diagnosis being critical for effective clinical intervention. Electroencephalography (EEG) offers a noninvasive and cost-effective means of detecting PD-related neural alterations, yet the development of reliable automated diagnostic models remains a challenge. In this study, we conduct a systematic benchmark of traditional machine learning (ML) and deep learning (DL) models for classifying PD using a publicly available oddball task dataset. Our aim is to lay the groundwork for developing an effective learning system and to determine which approach produces the best results. W e implement a unified seven-step prepro-cessing pipeline and apply consistent subject-wise cross-validation and evaluation criteria to ensure comparability across models. Our results demonstrate that while baseline deep learning architectures, particularly CNN-LSTM models, achieve the best performance compared to other deep learning architectures, underlining the importance of capturing long-range temporal dependencies, several traditional classifiers such as XGBoost also offer strong predictive accuracy and calibrated decision boundaries. By rigorously comparing these baselines, our work provides a solid reference framework for future studies aiming to develop and evaluate more complex or specialized architectures. Establishing a reliable set of baseline results is essential to contextualize improvements introduced by novel methods, ensuring scientific rigor and reproducibility in the evolving field of EEG-based neurodiagnostics.

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