The rapid evolution of artificial intelligence (AI), together with the increased availability of social media and news for epidemiological surveillance, are marking a pivotal moment in epidemiology and public health research. Leveraging the power of generative AI, we use an ensemble approach which incorporates multiple Large Language Models (LLMs) to extract valuable actionable epidemiological information from the World Health Organization (WHO) Disease Outbreak News (DONs). DONs is a collection of regular reports on global outbreaks curated by the WHO and the adopted decision-making processes to respond to them. The extracted information is made available in a daily-updated dataset and a knowledge graph, referred to as eKG, derived to provide a nuanced representation of the public health domain knowledge. We provide an overview of this new dataset and describe the structure of eKG, along with the services and tools used to access and utilize the data that we are building on top. These innovative data resources open altogether new opportunities for epidemiological research, and the analysis and surveillance of disease outbreaks.

Artificial intelligence is often measured by the range of tasks it can perform. Yet wide ability without depth remains only an imitation. This paper proposes a Structural-Generative Ontology of Intelligence: true intelligence exists only when a system can generate new structures, coordinate them into reasons, and sustain its identity over time. These three conditions -- generativity, coordination, and sustaining -- define the depth that underlies real intelligence. Current AI systems, however broad in function, remain surface simulations because they lack this depth. Breadth is not the source of intelligence but the growth that follows from depth. If future systems were to meet these conditions, they would no longer be mere tools, but could be seen as a possible Second Being, standing alongside yet distinct from human existence.

Trisomy 21 results in Down syndrome, a multifaceted genetic disorder with diverse clinical phenotypes, including heart defects, immune dysfunction, neurodevelopmental differences, and early-onset dementia risk. Heterogeneity and fragmented data across studies challenge comprehensive research and translational discovery. The NIH INCLUDE (INvestigation of Co-occurring conditions across the Lifespan to Understand Down syndromE) initiative has assembled harmonized participant-level datasets, yet realizing their potential requires integrative analytical frameworks. We developed a knowledge graph-driven platform transforming nine INCLUDE studies, comprising 7,148 participants, 456 conditions, 501 phenotypes, and over 37,000 biospecimens, into a unified semantic infrastructure. Cross-resource enrichment with Monarch Initiative data expands coverage to 4,281 genes and 7,077 variants. The resulting knowledge graph contains over 1.6 million semantic associations, enabling AI-ready analysis with graph embeddings and path-based reasoning for hypothesis generation. Researchers can query the graph via SPARQL or natural language interfaces. This framework converts static data repositories into dynamic discovery environments, supporting cross-study pattern recognition, predictive modeling, and systematic exploration of genotype-phenotype relationships in Down syndrome.

Animating a Knowledge Base: From Ontologies to Generative AI Models From Expert Systems and the Semantic W eb to Generative AI: Model - Driven and Data - Driven Approaches in Area Studies In a context where the social sciences and humanities are experimenting with non - anthropocentric analytical frames, this article proposes a semiotic (structural) reading of the hybridization between symbolic AI and neural (or sub - symbolic) AI based on a field of application: the design and use of a knowledge base for area studies. W e describe the LaCAS ecosystem - Open Archives in Linguistic and Cultural Studies (thesaurus; RDF/OWL ontology; LOD services; harvesting; expertise; publication), deployed at Inalco (National Institute for Oriental Languages and Civilizations) in Paris with the Okapi (Open Knowledge and Annotation Interface) software environment from Ina (National Audiovisual Institute), which now has around 160,000 documentary r esources and ten knowledge macro - domains grouping together several thousand knowledge objects. W e illustrate this approach using the knowledge domain "Languages of the world" (~540 languages) and the knowledge object "Quechua (language)". On this basis, we discuss the controlled integration of neural tools, more specifically generative tools, into the life cycle of a knowledge base: assistance with data localization/qualification, index extraction and aggregation, property suggestion and testing, dynamic file generation, and engineering of contextualized prompts (generic, contextual, explanatory, adjustment, procedural) aligned with a domain ontology. W e outline an ecosystem of specialized agents capable of animating the database while respe cting its symbolic constraints, by articulating model - driven and data - driven methods .

The making of knowledge engines in natural language processing has been shaped by two seemingly distinct paradigms: one grounded in structure, the other driven by massively available unstructured data. The structured paradigm leverages predefined symbolic interactions, such as knowledge graphs, as priors and designs models to capture them. In contrast, the unstructured paradigm centers on scaling transformer architectures with increasingly vast data and model sizes, as seen in modern large language models. Despite their divergence, this thesis seeks to establish conceptual connections bridging these paradigms. Two complementary forces, structure and destructure, emerge across both paradigms: structure organizes seen symbolic interactions, while destructure, through periodic embedding resets, improves model plasticity and generalization to unseen scenarios. These connections form a new recipe for developing general knowledge engines that can support transparent, controllable, and adaptable intelligent systems.

Effective Cyber Threat Intelligence (CTI) relies upon accurately structured and semantically enriched information extracted from cybersecurity system logs. However, current methodologies often struggle to identify and interpret malicious events reliably and transparently, particularly in cases involving unstructured or ambiguous log entries. In this work, we propose a novel methodology that combines ontology-driven structured outputs with Large Language Models (LLMs), to build an Artificial Intelligence (AI) agent that improves the accuracy and explainability of information extraction from cybersecurity logs. Central to our approach is the integration of domain ontologies and SHACL-based constraints to guide the language model's output structure and enforce semantic validity over the resulting graph. Extracted information is organized into an ontology-enriched graph database, enabling future semantic analysis and querying. The design of our methodology is motivated by the analytical requirements associated with honeypot log data, which typically comprises predominantly malicious activity. While our case study illustrates the relevance of this scenario, the experimental evaluation is conducted using publicly available datasets. Results demonstrate that our method achieves higher accuracy in information extraction compared to traditional prompt-only approaches, with a deliberate focus on extraction quality rather than processing speed.

Y et, prevailing methods, which rely on static scoring functions over learned embeddings, struggling to simultaneously capture rich semantic context and the dynamic nature of relations. T o overcome this limitation, we propose the Flow-Modulated Scoring (FMS) framework, conceptualizing a relation as a dynamic evolutionary process governed by its static semantic environment. FMS operates in two stages: it first learns context-aware entity embeddings via a Semantic Context Learning module, and then models a dynamic flow between them using a Conditional Flow-Matching module. This learned flow dynamically modulates a base static score for the entity pair. By unifying context-rich static representations with a conditioned dynamic flow, FMS achieves a more comprehensive understanding of relational semantics. Extensive experiments demonstrate that FMS establishes a new state of the art across both canonical knowledge graph completion tasks: relation prediction and entity prediction. On the standard relation prediction benchmark FB15k-237, FMS achieves a near-perfect MRR of 99.8% and Hits@1 of 99.7% using a mere 0.35M parameters, while also attaining a 99.9% MRR on WN18RR. Its dominance extends to entity prediction, where it secures a 25.2% relative MRR gain in the transductive setting and substantially outperforms all baselines in challenging inductive settings. By unifying a dynamic flow mechanism with rich static contexts, FMS offers a highly effective and parameter-efficient new paradigm for knowledge graph completion.

In industry, software testing is the primary method to verify and validate the functionality, performance, security, usability, and so on, of software-based systems. Test automation has gained increasing attention in industry over the last decade, following decades of intense research into test automation and model-based testing. However, designing, developing, maintaining and evolving test automation is a considerable effort. Meanwhile, AI's breakthroughs in many engineering fields are opening up new perspectives for software testing, for both manual and automated testing. This paper reviews recent research on AI augmentation in software test automation, from no automation to full automation. It also discusses new forms of testing made possible by AI. Based on this, the newly developed taxonomy, ai4st, is presented and used to classify recent research and identify open research questions.

Medical ontology graphs map external knowledge to medical codes in electronic health records via structured relationships. By leveraging domain-approved connections (e.g., parent-child), predictive models can generate richer medical concept representations by incorporating contextual information from related concepts. However, existing literature primarily focuses on incorporating domain knowledge from a single ontology system, or from multiple ontology systems (e.g., diseases, drugs, and procedures) in isolation, without integrating them into a unified learning structure. Consequently, concept representation learning often remains limited to intra-ontology relationships, overlooking cross-ontology connections. In this paper, we propose LINKO, a large language model (LLM)-augmented integrative ontology learning framework that leverages multiple ontology graphs simultaneously by enabling dual-axis knowledge propagation both within and across heterogeneous ontology systems to enhance medical concept representation learning. Specifically, LINKO first employs LLMs to provide a graph-retrieval-augmented initialization for ontology concept embedding, through an engineered prompt that includes concept descriptions, and is further augmented with ontology context. Second, our method jointly learns the medical concepts in diverse ontology graphs by performing knowledge propagation in two axes: (1) intra-ontology vertical propagation across hierarchical ontology levels and (2) inter-ontology horizontal propagation within every level in parallel. Last, through extensive experiments on two public datasets, we validate the superior performance of LINKO over state-of-the-art baselines. As a plug-in encoder compatible with existing EHR predictive models, LINKO further demonstrates enhanced robustness in scenarios involving limited data availability and rare disease prediction.

Ontologies and taxonomies of research fields are critical for managing and organising scientific knowledge, as they facilitate efficient classification, dissemination and retrieval of information. However, the creation and maintenance of such ontologies are expensive and time-consuming tasks, usually requiring the coordinated effort of multiple domain experts. Consequently, ontologies in this space often exhibit uneven coverage across different disciplines, limited inter-domain connectivity, and infrequent updating cycles. In this study, we investigate the capability of several large language models to identify semantic relationships among research topics within three academic domains: biomedicine, physics, and engineering. The models were evaluated under three distinct conditions: zero-shot prompting, chain-of-thought prompting, and fine-tuning on existing ontologies. Additionally, we assessed the cross-domain transferability of fine-tuned models by measuring their performance when trained in one domain and subsequently applied to a different one. To support this analysis, we introduce PEM-Rel-8K, a novel dataset consisting of over 8,000 relationships extracted from the most widely adopted taxonomies in the three disciplines considered in this study: MeSH, PhySH, and IEEE. Our experiments demonstrate that fine-tuning LLMs on PEM-Rel-8K yields excellent performance across all disciplines.