Systems biology, the study of the intricate, ramified, com-plex and interacting mechanisms underlying life, often proves too complex for unaided human understanding, even by groups of people working together. This difficulty is ex-acerbated by the high volume of publications in molecular biology. The Big C (‘C’ for Cyc) is a system designed to (semi-)automatically acquire, integrate, and use complex mechanism models, specifically related to cancer biology, via automated reading and a hyper-detailed refinement pro-cess resting on Cyc’s logical representations and powerful inference mechanisms. We aim to assist cancer research and treatment by achieving elements of biologist-level reason-ing, but with the scale and attention to detail that only com-puter implementations can provide.

This paper deals with the binary classification task when the target class has the lower probability of occurrence. In such situation, it is not possible to build a powerful classifier by using standard methods such as logistic regression, classification tree, discriminant analysis, etc. To overcome this short-coming of these methods which yield classifiers with low sensibility, we tackled the classification problem here through an approach based on the association rules learning. This approach has the advantage of allowing the identification of the patterns that are well correlated with the target class. Association rules learning is a well known method in the area of data-mining. It is used when dealing with large database for unsupervised discovery of local patterns that expresses hidden relationships between input variables. In considering association rules from a supervised learning point of view, a relevant set of weak classifiers is obtained from which one derives a classifier that performs well.

The production system is a theoretical model of computation relevant to the artificial intelligence field allowing for problem solving procedures such as hierarchical tree search. In this work we explore some of the connections between artificial intelligence and quantum computation by presenting a model for a quantum production system. Our approach focuses on initially developing a model for a reversible production system which is a simple mapping of Bennett's reversible Turing machine. We then expand on this result in order to accommodate for the requirements of quantum computation. We present the details of how our proposition can be used alongside Grover's algorithm in order to yield a speedup comparatively to its classical counterpart. We discuss the requirements associated with such a speedup and how it compares against a similar quantum hierarchical search approach.

Based on the Aristotelian concept of potentiality vs. actuality allowing for the study of energy and dynamics in language, we propose a field approach to lexical analysis. Falling back on the distributional hypothesis to statistically model word meaning, we used evolving fields as a metaphor to express time-dependent changes in a vector space model by a combination of random indexing and evolving self-organizing maps (ESOM). To monitor semantic drifts within the observation period, an experiment was carried out on the term space of a collection of 12.8 million Amazon book reviews. For evaluation, the semantic consistency of ESOM term clusters was compared with their respective neighbourhoods in WordNet, and contrasted with distances among term vectors by random indexing. We found that at 0.05 level of significance, the terms in the clusters showed a high level of semantic consistency. Tracking the drift of distributional patterns in the term space across time periods, we found that consistency decreased, but not at a statistically significant level. Our method is highly scalable, with interpretations in philosophy.

The search is "small" in the sense that the size of

This is the second of two papers about MOLGEN.

Instead they have commonly assigned structure to a domain using statistical techniques such as Bayes' Theorem

"Almost all the basic methods used by

ABSTRACT Prospector is a computer consultant system intended to aid geologists in evaluating the favorability of an exploration site or region for occurrences of ore deposits of particular types. Knowledge about a particular type of ore deposit is encoded in a computational model representing observable geological features and the relative significance thereof. We describe the form of models in Prospector, focussing on inference networks of geological assertions and the Bayesian propagation formalism used to represent the judgmental reasoning process of the economic geologist who serves as model designer. Following the initial design of a model, simple performance evaluation techniques are used to assess the extent to which the performance of the model reflects faithfully the intent of the model designer. These results identify specific portions of the model that might benefit from "fine tuning", and establish priorities for such revisions. This description of the Prospector system and the model design process serves to illustrate the process of transferring human expertise about a subjective domain into a mechanical realization. I. INTRODUCTION In an increasingly complex and specialized world, human expertise about diverse subjects spanning scientific, economic, social, and political issues plays an increasingly important role in the functioning of all kinds of organizations. Although computers have become indispensable tools in many endeavors, we continue to rely heavily on the human expert's ability to identify and synthesize diverse factors, to form judgments, evaluate alternatives, and make decisions -- in sum, to apply his or her years of experience to the problem at hand. This is especially valid with regard to domains that are not easily amenable to precise scientific formulations, i.e., to domains in which experience and subjective judgment plays a major role.

TEntEsuis is a program designed to provide assistance on the task of building knowledge-based results and motivations for its actions.