Many of society's most pressing challenges, from pandemic response to supply chain disruptions to climate adaptation, emerge from the collective behavior of millions of autonomous agents making decisions over time. Large Population Models (LPMs) offer an approach to understand these complex systems by simulating entire populations with realistic behaviors and interactions at unprecedented scale. LPMs extend traditional modeling approaches through three key innovations: computational methods that efficiently simulate millions of agents simultaneously, mathematical frameworks that learn from diverse real-world data streams, and privacy-preserving communication protocols that bridge virtual and physical environments. This allows researchers to observe how agent behavior aggregates into system-level outcomes and test interventions before real-world implementation. While current AI advances primarily focus on creating "digital humans" with sophisticated individual capabilities, LPMs develop "digital societies" where the richness of interactions reveals emergent phenomena. By bridging individual agent behavior and population-scale dynamics, LPMs offer a complementary path in AI research illuminating collective intelligence and providing testing grounds for policies and social innovations before real-world deployment. We discuss the technical foundations and some open problems here. LPMs are implemented by the AgentTorch framework (github.com/AgentTorch/AgentTorch)

Autonomous vehicles (AVs) are becoming increasingly popular, with their applications now extending beyond just a mode of transportation to serving as mobile actuators of a traffic flow to control flow dynamics. This contrasts with traditional fixed-location actuators, such as traffic signals, and is referred to as Lagrangian traffic control. However, designing effective Lagrangian traffic control policies for AVs that generalize across traffic scenarios introduces a major challenge. Real-world traffic environments are highly diverse, and developing policies that perform robustly across such diverse traffic scenarios is challenging. It is further compounded by the joint complexity of the multi-agent nature of traffic systems, mixed motives among participants, and conflicting optimization objectives subject to strict physical and external constraints. To address these challenges, we introduce Multi-Residual Mixture of Expert Learning (MRMEL), a novel framework for Lagrangian traffic control that augments a given suboptimal nominal policy with a learned residual while explicitly accounting for the structure of the traffic scenario space. In particular, taking inspiration from residual reinforcement learning, MRMEL augments a suboptimal nominal AV control policy by learning a residual correction, but at the same time dynamically selects the most suitable nominal policy from a pool of nominal policies conditioned on the traffic scenarios and modeled as a mixture of experts. We validate MRMEL using a case study in cooperative eco-driving at signalized intersections in Atlanta, Dallas Fort Worth, and Salt Lake City, with real-world data-driven traffic scenarios. The results show that MRMEL consistently yields superior performance-achieving an additional 4%-9% reduction in aggregate vehicle emissions relative to the strongest baseline in each setting.

Recent advances in Large Language Models (LLM) have led to a new class of autonomous agents, renewing and expanding interest in the area. LLM-powered Multiagent Systems (MAS) have thus emerged, both for assistive and simulation purposes, yet tools for realistic human behavior simulation -- with its distinctive challenges and opportunities -- remain underdeveloped. Existing MAS libraries and tools lack fine-grained persona specifications, population sampling facilities, experimentation support, and integrated validation, among other key capabilities, limiting their utility for behavioral studies, social simulation, and related applications. To address these deficiencies, in this work we introduce TinyTroupe, a simulation toolkit enabling detailed persona definitions (e.g., nationality, age, occupation, personality, beliefs, behaviors) and programmatic control via numerous LLM-driven mechanisms. This allows for the concise formulation of behavioral problems of practical interest, either at the individual or group level, and provides effective means for their solution. TinyTroupe's components are presented using representative working examples, such as brainstorming and market research sessions, thereby simultaneously clarifying their purpose and demonstrating their usefulness. Quantitative and qualitative evaluations of selected aspects are also provided, highlighting possibilities, limitations, and trade-offs. The approach, though realized as a specific Python implementation, is meant as a novel conceptual contribution, which can be partially or fully incorporated in other contexts. The library is available as open source at https://github.com/microsoft/tinytroupe.

Artificial intelligence (AI) systems often interact with multiple agents. The regulation of such AI systems often requires that {\em a priori\/} guarantees of fairness and robustness be satisfied. With stochastic models of agents' responses to the outputs of AI systems, such {\em a priori\/} guarantees require non-trivial reasoning about the corresponding stochastic systems. Here, we present an open-source PyTorch-based toolkit for the use of stochastic control techniques in modelling interconnections of AI systems and properties of their repeated uses. It models robustness and fairness desiderata in a closed-loop fashion, and provides {\em a priori\/} guarantees for these interconnections. The PyTorch-based toolkit removes much of the complexity associated with the provision of fairness guarantees for closed-loop models of multi-agent systems.

Multi-agent reinforcement learning faces fundamental challenges that conventional approaches have failed to overcome: exponentially growing joint action spaces, non-stationary environments where simultaneous learning creates moving targets, and partial observability that constrains coordination. Current methods remain reactive, employing stimulus-response mechanisms that fail when facing novel scenarios. We argue for a transformative paradigm shift from reactive to proactive multi-agent intelligence through generative AI-based reinforcement learning. This position advocates reconceptualizing agents not as isolated policy optimizers, but as sophisticated generative models capable of synthesizing complex multi-agent dynamics and making anticipatory decisions based on predictive understanding of future interactions. Rather than responding to immediate observations, generative-RL agents can model environment evolution, predict other agents' behaviors, generate coordinated action sequences, and engage in strategic reasoning accounting for long-term dynamics. This approach leverages pattern recognition and generation capabilities of generative AI to enable proactive decision-making, seamless coordination through enhanced communication, and dynamic adaptation to evolving scenarios. We envision this paradigm shift will unlock unprecedented possibilities for distributed intelligence, moving beyond individual optimization toward emergent collective behaviors representing genuine collaborative intelligence. The implications extend across autonomous systems, robotics, and human-AI collaboration, promising solutions to coordination challenges intractable under traditional reactive frameworks.

Social learning is a powerful mechanism through which agents learn about the world from others. However, humans don't always choose to observe others, since social learning can carry time and cognitive resource costs. How do people balance social and non-social learning? In this paper, we propose a rational mentalizing model of the decision to engage in social learning. This model estimates the utility of social learning by reasoning about the other agent's goal and the informativity of their future actions. It then weighs the utility of social learning against the utility of self-exploration (non-social learning). Using a multi-player treasure hunt game, we show that our model can quantitatively capture human trade-offs between social and non-social learning. Furthermore, our results indicate that these two components allow agents to flexibly apply social learning to achieve their goals more efficiently.

We present StockSim, an open-source simulation platform for systematic evaluation of large language models (LLMs) in realistic financial decision-making scenarios. Unlike previous toolkits that offer limited scope, StockSim delivers a comprehensive system that fully models market dynamics and supports diverse simulation modes of varying granularity. It incorporates critical real-world factors, such as latency, slippage, and order-book microstructure, that were previously neglected, enabling more faithful and insightful assessment of LLM-based trading agents. An extensible, role-based agent framework supports heterogeneous trading strategies and multi-agent coordination, making StockSim a uniquely capable testbed for NLP research on reasoning under uncertainty and sequential decision-making. We open-source all our code at https: //github.com/harrypapa2002/StockSim.

Developing autonomous agents that quickly explore an environment and adapt their behavior online is a canonical challenge in robotics and machine learning. While humans are able to achieve such fast online exploration and adaptation, often acquiring new information and skills in only a handful of interactions, existing algorithmic approaches tend to rely on random exploration and slow, gradient-based behavior updates. How can we endow autonomous agents with such capabilities on par with humans? Taking inspiration from recent progress on both in-context learning and large-scale behavioral cloning, in this work we propose behavioral exploration: training agents to internalize what it means to explore and adapt in-context over the space of ``expert'' behaviors. To achieve this, given access to a dataset of expert demonstrations, we train a long-context generative model to predict expert actions conditioned on a context of past observations and a measure of how ``exploratory'' the expert's behaviors are relative to this context. This enables the model to not only mimic the behavior of an expert, but also, by feeding its past history of interactions into its context, to select different expert behaviors than what have been previously selected, thereby allowing for fast online adaptation and targeted, ``expert-like'' exploration. We demonstrate the effectiveness of our method in both simulated locomotion and manipulation settings, as well as on real-world robotic manipulation tasks, illustrating its ability to learn adaptive, exploratory behavior.

The pharmaceutical industry faces unprecedented challenges in drug discovery, with traditional approaches struggling to meet modern therapeutic development demands. This paper introduces a novel AI framework, Tippy, that transforms laboratory automation through specialized AI agents operating within the Design-Make-Test-Analyze (DMTA) cycle. Our multi-agent system employs five specialized agents - Supervisor, Molecule, Lab, Analysis, and Report, with Safety Guardrail oversight - each designed to excel in specific phases of the drug discovery pipeline. Tippy represents the first production-ready implementation of specialized AI agents for automating the DMTA cycle, providing a concrete example of how AI can transform laboratory workflows. By leveraging autonomous AI agents that reason, plan, and collaborate, we demonstrate how Tippy accelerates DMTA cycles while maintaining scientific rigor essential for pharmaceutical research. The system shows significant improvements in workflow efficiency, decision-making speed, and cross-disciplinary coordination, offering a new paradigm for AI-assisted drug discovery.

Large Language Models (LLMs) have achieved strong performance on a wide range of complex reasoning tasks, yet further gains are often possible by leveraging the complementary strengths of multiple models. While multi-agent frameworks can improve solution quality by leveraging multiple LLMs, existing methods are often computationally expensive, both at training and inference time. In this work, we introduce a hierarchical multi-agent framework that addresses these challenges by training only a single leader LLM to coordinate a team of untrained peer agents. To this end, we propose Multi-agent guided Leader Policy \textbf{O}ptimization (MLPO), a novel approach which trains the leader to evaluate and synthesize agent responses without auxiliary value networks or explicit agent feedback. Leaders trained with MLPO exhibit improved performance not only when interacting with the agent team at inference time, but also enjoy improved performance when deployed in single-agent settings without the team. Empirical results on Big-Bench Hard (BBH), MATH, and MMLU demonstrate that our framework achieves substantial performance improvements over both single-agent and multi-agent baselines. Our results highlight the effectiveness and efficiency of training a single, flexible leader for collaborative reasoning in multi-agent LLM systems.