Head-and-neck cancer (HNC) planning is difficult because multiple critical organs-at-risk (OARs) are close to complex targets. Intensity-modulated carbon-ion therapy (IMCT) offers superior dose conformity and OAR sparing but remains slow due to relative biological effectiveness (RBE) modeling, leading to laborious, experience-based, and often suboptimal tuning of many treatment-planning parameters (TPPs). Recent deep learning (DL) methods are limited by data bias and plan feasibility, while reinforcement learning (RL) struggles to efficiently explore the exponentially large TPP search space. We propose a scalable multi-agent RL (MARL) framework for parallel tuning of 45 TPPs in IMCT. It uses a centralized-training decentralized-execution (CTDE) QMIX backbone with Double DQN, Dueling DQN, and recurrent encoding (DRQN) for stable learning in a high-dimensional, non-stationary environment. To enhance efficiency, we (1) use compact historical DVH vectors as state inputs, (2) apply a linear action-to-value transform mapping small discrete actions to uniform parameter adjustments, and (3) design an absolute, clinically informed piecewise reward aligned with plan scores. A synchronous multi-process worker system interfaces with the PHOENIX TPS for parallel optimization and accelerated data collection. On a head-and-neck dataset (10 training, 10 testing), the method tuned 45 parameters simultaneously and produced plans comparable to or better than expert manual ones (relative plan score: RL $85.93\pm7.85%$ vs Manual $85.02\pm6.92%$), with significant (p-value $<$ 0.05) improvements for five OARs. The framework efficiently explores high-dimensional TPP spaces and generates clinically competitive IMCT plans through direct TPS interaction, notably improving OAR sparing.

We study the problem of learning multi-task, multi-agent policies for cooperative, temporal objectives, under centralized training, decentralized execution. In this setting, using automata to represent tasks enables the decomposition of complex tasks into simpler sub-tasks that can be assigned to agents. However, existing approaches remain sample-inefficient and are limited to the single-task case. In this work, we present Automata-Conditioned Cooperative Multi-Agent Reinforcement Learning (ACC-MARL), a framework for learning task-conditioned, decentralized team policies. We identify the main challenges to ACC-MARL's feasibility in practice, propose solutions, and prove the correctness of our approach. We further show that the value functions of learned policies can be used to assign tasks optimally at test time. Experiments show emergent task-aware, multi-step coordination among agents, e.g., pressing a button to unlock a door, holding the door, and short-circuiting tasks.

While existing work focuses primarily on task success, we argue that effective real-world agents require optimizing three dimensions: productivity (task completion), proactivity (asking essential questions), and personalization (adapting to diverse user preferences). We introduce UserVille, an interactive environment with LLM-based user simulators enabling diverse, configurable user preferences. Leveraging UserVille, we introduce PPP, a multi-objective reinforcement learning approach that jointly optimizes all three dimensions: Productivity, Proactivity, and Personalization. Experiments on software engineering and deep research tasks show that agents trained with PPP achieve substantial improvements over strong baselines such as GPT-5 (+21.6 on average), demonstrating the ability to ask strategic clarifying questions, adapt to unseen user preferences, and improve task success through better interaction. This work demonstrates that explicitly optimizing for user-centered interaction is critical for building practical and effective AI agents.

The emergence of multi-agent systems powered by large language models (LLMs) has unlocked new frontiers in complex task-solving, enabling diverse agents to integrate unique expertise, collaborate flexibly, and address challenges unattainable for individual models. However, the full potential of such systems is hindered by rigid agent scheduling and inefficient coordination strategies that fail to adapt to evolving task requirements. In this paper, we propose STRMAC, a state-aware routing framework designed for efficient collaboration in multi-agent systems. Our method separately encodes interaction history and agent knowledge to power the router, which adaptively selects the most suitable single agent at each step for efficient and effective collaboration. Furthermore, we introduce a self-evolving data generation approach that accelerates the collection of high-quality execution paths for efficient system training. Experiments on challenging collaborative reasoning benchmarks demonstrate that our method achieves state-of-the-art performance, achieving up to 23.8% improvement over baselines and reducing data collection overhead by up to 90.1% compared to exhaustive search.

This paper presents a quantitative comparison between centralised and distributed multi-agent reinforcement learning (MARL) architectures for controlling a soft robotic arm modelled as a Cosserat rod in simulation. Using PyElastica and the OpenAI Gym interface, we train both a global Proximal Policy Optimisation (PPO) controller and a Multi-Agent PPO (MAPPO) under identical budgets. Both approaches are based on the arm having $n$ number of controlled sections. The study systematically varies $n$ and evaluates the performance of the arm to reach a fixed target in three scenarios: default baseline condition, recovery from external disturbance, and adaptation to actuator failure. Quantitative metrics used for the evaluation are mean action magnitude, mean final distance, mean episode length, and success rate. The results show that there are no significant benefits of the distributed policy when the number of controlled sections $n\le4$. In very simple systems, when $n\le2$, the centralised policy outperforms the distributed one. When $n$ increases to $4< n\le 12$, the distributed policy shows a high sample efficiency. In these systems, distributed policy promotes a stronger success rate, resilience, and robustness under local observability and yields faster convergence given the same sample size. However, centralised policies achieve much higher time efficiency during training as it takes much less time to train the same size of samples. These findings highlight the trade-offs between centralised and distributed policy in reinforcement learning-based control for soft robotic systems and provide actionable design guidance for future sim-to-real transfer in soft rod-like manipulators.

Collaborating teams of robots show promise due in their ability to complete missions more efficiently and with improved robustness, attributes that are particularly useful for systems operating in marine environments. A key issue is how to model, analyze, and design these multi-robot systems to realize the full benefits of collaboration, a challenging task since the domain of multi-robot autonomy encompasses both collective and individual behaviors. This paper introduces a layered model of multi-robot autonomy that uses the principle of census, or a weighted count of the inputs from neighbors, for collective decision-making about teaming, coupled with multi-objective behavior optimization for individual decision-making about actions. The census component is expressed as a nonlinear opinion dynamics model and the multi-objective behavior optimization is accomplished using interval programming. This model can be reduced to recover foundational algorithms in distributed optimization and control, while the full model enables new types of collective behaviors that are useful in real-world scenarios. To illustrate these points, a new method for distributed optimization of subgroup allocation is introduced where robots use a gradient descent algorithm to minimize portions of the cost functions that are locally known, while being influenced by the opinion states from neighbors to account for the unobserved costs. With this method the group can collectively use the information contained in the Hessian matrix of the total global cost. The utility of this model is experimentally validated in three categorically different experiments with fleets of autonomous surface vehicles: an adaptive sampling scenario, a high value unit protection scenario, and a competitive game of capture the flag.

We propose Re-FORC, an adaptive reward prediction method that, given a context, enables prediction of the expected future rewards as a function of the number of future thinking tokens. Re-FORC trains a lightweight adapter on reasoning models, demonstrating improved prediction with longer reasoning and larger models. Re-FORC enables: 1) early stopping of unpromising reasoning chains, reducing compute by 26% while maintaining accuracy, 2) optimized model and thinking length selection that achieves 4% higher accuracy at equal compute and 55% less compute at equal accuracy compared to the largest model, 3) adaptive test-time scaling, which increases accuracy by 11% in high compute regime, and 7% in low compute regime. Re-FORC allows dynamic reasoning with length control via cost-per-token thresholds while estimating computation time upfront.

Scientific experiment and manufacture rely on complex, multi-step procedures that demand continuous human expertise for precise execution and decision-making. Despite advances in machine learning and automation, conventional models remain confined to virtual domains, while real-world experiment and manufacture still rely on human supervision and expertise. This gap between machine intelligence and physical execution limits reproducibility, scalability, and accessibility across scientific and manufacture workflows. Here, we introduce human-AI co-embodied intelligence, a new form of physical AI that unites human users, agentic AI, and wearable hardware into an integrated system for real-world experiment and intelligent manufacture. In this paradigm, humans provide precise execution and control, while agentic AI contributes memory, contextual reasoning, adaptive planning, and real-time feedback. The wearable interface continuously captures the experimental and manufacture processes, facilitates seamless communication between humans and AI for corrective guidance and interpretable collaboration. As a demonstration, we present Agentic-Physical Experimentation (APEX) system, coupling agentic reasoning with physical execution through mixed-reality. APEX observes and interprets human actions, aligns them with standard operating procedures, provides 3D visual guidance, and analyzes every step. Implemented in a cleanroom for flexible electronics fabrication, APEX system achieves context-aware reasoning with accuracy exceeding general multimodal large language models, corrects errors in real time, and transfers expertise to beginners. These results establish a new class of agentic-physical-human intelligence that extends agentic reasoning beyond computation into the physical domain, transforming scientific research and manufacturing into autonomous, traceable, interpretable, and scalable processes.

We present ABIDES-MARL, a framework that combines a new multi-agent reinforcement learning (MARL) methodology with a new realistic limit-order-book (LOB) simulation system to study equilibrium behavior in complex financial market games. The system extends ABIDES-Gym by decoupling state collection from kernel interruption, enabling synchronized learning and decision-making for multiple adaptive agents while maintaining compatibility with standard RL libraries. It preserves key market features such as price-time priority and discrete tick sizes. Methodologically, we use MARL to approximate equilibrium-like behavior in multi-period trading games with a finite number of heterogeneous agents-an informed trader, a liquidity trader, noise traders, and competing market makers-all with individual price impacts. This setting bridges optimal execution and market microstructure by embedding the liquidity trader's optimization problem within a strategic trading environment. We validate the approach by solving an extended Kyle model within the simulation system, recovering the gradual price discovery phenomenon. We then extend the analysis to a liquidity trader's problem where market liquidity arises endogenously and show that, at equilibrium, execution strategies shape market-maker behavior and price dynamics. ABIDES-MARL provides a reproducible foundation for analyzing equilibrium and strategic adaptation in realistic markets and contributes toward building economically interpretable agentic AI systems for finance.

Recent advances in LLM Multi-Agent Systems enable scalable orchestration of sub-agents, each coordinating hundreds or thousands of tools or Model Context Protocol (MCP) servers. However, existing retrieval methods typically match queries against coarse agent-level descriptions before routing, which obscures fine-grained tool functionality and often results in suboptimal agent selection. We introduce Tool-to-Agent Retrieval, a unified framework that embeds both tools and their parent agents in a shared vector space and connects them through metadata relationships. By explicitly representing tool capabilities and traversing metadata to the agent level, Tool-to-Agent Retrieval enables granular tool-level or agent-level retrieval, ensuring that agents and their underlying tools or MCP servers are equally represented without the context dilution that arises from chunking many tools together. Evaluating Tool-to-Agent Retrieval across eight embedding models, our approach achieves consistent improvements of 19.4% in Recall@5 and 17.7% in nDCG@5 over previous state-of-the-art agent retrievers on the LiveM-CPBench benchmark.