Welcome to our monthly digest, where you can catch up with any AIhub stories you may have missed, peruse the latest news, recap recent events, and more. This month, we learn about rewarding explainability in drug repurposing with knowledge graphs, investigate value-aligned autonomous vehicles, and consider trust in multi-agent systems. In this blog post, and write about work, presented at the International Joint Conference on Artificial Intelligence (IJCAI2025), on rewarding explainability in drug repurposing with knowledge graphs. Their work introduces a reinforcement learning approach that not only predicts which drug-disease pairs might hold promise but also explains why. Astrid Rakow writes about designing "conflict-sensitive" autonomous traffic agents that explicitly recognise, reason about, and act upon competing ethical, legal, and social values.

Generations in Dialogue: Bridging Perspectives in AI is a podcast from AAAI featuring thought-provoking discussions between AI experts, practitioners, and enthusiasts from different age groups and backgrounds. Each episode delves into how generational experiences shape views on AI, exploring the challenges, opportunities, and ethical considerations that come with the advancement of this transformative technology. In the third episode of this new series from AAAI, host Ella Lan chats to Professor Roberto Martín-Martín about taking a screwdriver to his toys as a child, how his research focus has evolved over time, how different generations interact with technology, making robots for everyone, being inspired by colleagues, advice for early-career researchers, and how machines can enhance human capabilities. Roberto Martín-Martín is an Assistant Professor of Computer Science at the University of Texas at Austin, where his research integrates robotics, computer vision, and machine learning to build autonomous agents capable of perceiving, learning, and acting in the real world. He previously worked as an AI Researcher at Salesforce AI and as a Postdoctoral Scholar at the Stanford Vision and Learning Lab with Silvio Savarese and Fei-Fei Li, leading projects in visuomotor learning, mobile manipulation, and human-robot interaction.

The roll-out of the European Union's Artificial Intelligence Act has hit a critical turning point. The act establishes rules for how AI systems can be used within the European Union. It officially entered into force on August 1 2024, although different rules come into effect at different times. The European Commission has now proposed delaying parts of the act until 2027. This follows intense pressure from tech companies and from the Trump administration.

With the rise of smart personal devices, service-oriented human-agent interactions have become increasingly prevalent. This trend highlights the need for personalized dialogue assistants that can understand user-specific traits to accurately interpret requirements and tailor responses to individual preferences. However, existing approaches often overlook the complexities of long-term interactions and fail to capture users' subjective characteristics. To address these gaps, we present PAL-Bench, a new benchmark designed to evaluate the personalization capabilities of service-oriented assistants in long-term user-agent interactions. In the absence of available real-world data, we develop a multi-step LLM-based synthesis pipeline, which is further verified and refined by human annotators. This process yields PAL-Set, the first Chinese dataset comprising multi-session user logs and dialogue histories, which serves as the foundation for PAL-Bench. Furthermore, to improve personalized service-oriented interactions, we propose H$^2$Memory, a hierarchical and heterogeneous memory framework that incorporates retrieval-augmented generation to improve personalized response generation. Comprehensive experiments on both our PAL-Bench and an external dataset demonstrate the effectiveness of the proposed memory framework.

Synthetic data has become increasingly important for training large language models, especially when real data is scarce, expensive, or privacy-sensitive. Many such generation tasks require coordinated multi-agent workflows, where specialized agents collaborate to produce data that is higher quality, more diverse, and structurally richer. However, existing frameworks for multi-agent synthesis often depend on a centralized orchestrator, creating scalability bottlenecks, or are hardcoded for specific domains, limiting flexibility. We present \textbf{Matrix}, a decentralized framework that represents both control and data flow as serialized messages passed through distributed queues. This peer-to-peer design eliminates the central orchestrator. Each task progresses independently through lightweight agents, while compute-intensive operations, such as LLM inference or containerized environments, are handled by distributed services. Built on Ray, Matrix scales to tens of thousands of concurrent agentic workflows and provides a modular, configurable design that enables easy adaptation to a wide range of data generation workflows. We evaluate Matrix across diverse synthesis scenarios, such as multi-agent collaborative dialogue, web-based reasoning data extraction, and tool-use trajectory generation in customer service environments. In all cases, Matrix achieves $2$--$15\times$ higher data generation throughput under identical hardware resources, without compromising output quality.

Large language model (LLM)-based multi-agent systems have emerged as a powerful paradigm for enabling autonomous agents to solve complex tasks. As these systems scale in complexity, cost becomes an important consideration for practical deployment. However, existing work rarely addresses how to structure multi-agent systems under explicit budget constraints. In this paper, we propose BAMAS, a novel approach for building multi-agent systems with budget awareness. BAMAS first selects an optimal set of LLMs by formulating and solving an Integer Linear Programming problem that balances performance and cost. It then determines how these LLMs should collaborate by leveraging a reinforcement learning-based method to select the interaction topology. Finally, the system is instantiated and executed based on the selected agents and their collaboration topology. We evaluate BAMAS on three representative tasks and compare it with state-of-the-art agent construction methods. Results show that BAMAS achieves comparable performance while reducing cost by up to 86%.

Ensuring the safety of embodied AI agents during task planning is critical for real-world deployment, especially in household environments where dangerous instructions pose significant risks. Existing methods often suffer from either high computational costs due to preference alignment training or over-rejection when using single-agent safety prompts. To address these limitations, we propose MADRA, a training-free Multi-Agent Debate Risk Assessment framework that leverages collective reasoning to enhance safety awareness without sacrificing task performance. MADRA employs multiple LLM-based agents to debate the safety of a given instruction, guided by a critical evaluator that scores responses based on logical soundness, risk identification, evidence quality, and clarity. Through iterative deliberation and consensus voting, MADRA significantly reduces false rejections while maintaining high sensitivity to dangerous tasks. Additionally, we introduce a hierarchical cognitive collaborative planning framework that integrates safety, memory, planning, and self-evolution mechanisms to improve task success rates through continuous learning. We also contribute SafeAware-VH, a benchmark dataset for safety-aware task planning in VirtualHome, containing 800 annotated instructions. Extensive experiments on AI2-THOR and VirtualHome demonstrate that our approach achieves over 90% rejection of unsafe tasks while ensuring that safe-task rejection is low, outperforming existing methods in both safety and execution efficiency. Our work provides a scalable, model-agnostic solution for building trustworthy embodied agents.

Cooperative multi-agent reinforcement learning (MARL) commonly adopts centralized training with decentralized execution (CTDE), where centralized critics leverage global information to guide decentralized actors. However, centralized-decentralized mismatch (CDM) arises when the suboptimal behavior of one agent degrades others' learning. Prior approaches mitigate CDM through value decomposition, but linear decompositions allow per-agent gradients at the cost of limited expressiveness, while nonlinear decompositions improve representation but require centralized gradients, reintroducing CDM. To overcome this trade-off, we propose the multi-agent cross-entropy method (MCEM), combined with monotonic nonlinear critic decomposition (NCD). MCEM updates policies by increasing the probability of high-value joint actions, thereby excluding suboptimal behaviors. For sample efficiency, we extend off-policy learning with a modified k-step return and Retrace. Analysis and experiments demonstrate that MCEM outperforms state-of-the-art methods across both continuous and discrete action benchmarks.

Extreme weather events pose escalating risks to global society, underscoring the urgent need to unravel their underlying physical mechanisms. Yet the prevailing expert-driven, labor-intensive diagnostic paradigm has created a critical analytical bottleneck, stalling scientific progress. While AI for Earth Science has achieved notable advances in prediction, the equally essential challenge of automated diagnostic reasoning remains largely unexplored. We present the Extreme Weather Expert (EWE), the first intelligent agent framework dedicated to this task. EWE emulates expert workflows through knowledge-guided planning, closed-loop reasoning, and a domain-tailored meteorological toolkit. It autonomously produces and interprets multimodal visualizations from raw meteorological data, enabling comprehensive diagnostic analyses. To catalyze progress, we introduce the first benchmark for this emerging field, comprising a curated dataset of 103 high-impact events and a novel step-wise evaluation metric. EWE marks a step toward automated scientific discovery and offers the potential to democratize expertise and intellectual resources, particularly for developing nations vulnerable to extreme weather.

Repurposing approved drugs offers a time-efficient and cost-effective alternative to traditional drug development. However, in silico prediction of repurposing candidates is challenging and requires the effective collaboration of specialists in various fields, including pharmacology, medicine, biology, and bioinformatics. Fragmented, specialized algorithms and tools often address only narrow aspects of the overall problem, and heterogeneous, unstructured data landscapes require specialized users to be involved. Hence, these data services do not integrate smoothly across workflows. With ChatDRex, we present a conversation-based, multi-agent system that facilitates the execution of complex bioinformatic analyses aiming for network-based drug repurposing prediction. It builds on the integrated systems medicine knowledge graph NeDRex. ChatDRex provides natural language access to its extensive biomedical KG and integrates bioinformatics agents for network analysis and drug repurposing, complemented by agents for functional coherence evaluation for in silico validation, as well as agents for literature mining and for discussing the obtained results in a scientific context. Its flexible multi-agent design assigns specific tasks to specialized agents, including query routing, data retrieval, algorithm execution, and result visualization. A dedicated reasoning module keeps the user in the loop and allows for hallucination detection. By enabling physicians and researchers without computer science expertise to control complex analyses in natural language, ChatDRex democratizes access to bioinformatics as an important resource for drug repurposing. It enables clinical experts to generate hypotheses and explore drug repurposing opportunities, ultimately accelerating the discovery of novel therapies and advancing personalized medicine and translational research.