State-of-the-art retrieval models typically address a straightforward search scenario, where retrieval tasks are fixed (e.g., finding a passage to answer a specific question) and only a single modality is supported for both queries and retrieved results. This paper introduces techniques for advancing information retrieval with multimodal large language models (MLLMs), enabling a broader search scenario, termed universal multimodal retrieval, where multiple modalities and diverse retrieval tasks are accommodated. To this end, we first study fine-tuning an MLLM as a bi-encoder retriever on 10 datasets with 16 retrieval tasks. Our empirical results show that the fine-tuned MLLM retriever is capable of understanding challenging queries, composed of both text and image, but underperforms a smaller CLIP retriever in cross-modal retrieval tasks due to modality bias from MLLMs. To address the issue, we propose modality-aware hard negative mining to mitigate the modality bias exhibited by MLLM retrievers. Second, we propose to continually fine-tune the universal multimodal retriever to enhance its text retrieval capability while maintaining multimodal retrieval capability. As a result, our model, MM-Embed, achieves state-of-the-art performance on the multimodal retrieval benchmark M-BEIR, which spans multiple domains and tasks, while also surpassing the state-of-the-art text retrieval model, NV-Embed-v1, on MTEB retrieval benchmark. Finally, we explore to prompt the off-the-shelf MLLMs as the zero-shot rerankers to refine the ranking of the candidates from the multimodal retriever. We find that through prompt-and-reranking, MLLMs can further improve multimodal retrieval when the user queries (e.g., text-image composed queries) are more complex and challenging to understand. These findings also pave the way to advance universal multimodal retrieval in the future.

Biomedical research requires large, diverse samples to produce unbiased results. Automated methods for matching variables across datasets can accelerate this process. Research in this area has been limited, primarily focusing on lexical matching and ontology based semantic matching. We aimed to develop new methods, leveraging large language models (LLM) and ensemble learning, to automate variable matching. Methods: We utilized data from two GERAS cohort (European and Japan) studies to develop variable matching methods. We first manually created a dataset by matching 352 EU variables with 1322 candidate JP variables, where matched variable pairs were positive and unmatched pairs were negative instances. Using this dataset, we developed and evaluated two types of natural language processing (NLP) methods, which matched variables based on variable labels and definitions from data dictionaries: (1) LLM-based and (2) fuzzy matching. We then developed an ensemble-learning method, using the Random Forest model, to integrate individual NLP methods. RF was trained and evaluated on 50 trials. Each trial had a random split (4:1) of training and test sets, with the model's hyperparameters optimized through cross-validation on the training set. For each EU variable, 1322 candidate JP variables were ranked based on NLP-derived similarity scores or RF's probability scores, denoting their likelihood to match the EU variable. Ranking performance was measured by top-n hit ratio (HRn) and mean reciprocal rank (MRR). Results:E5 performed best among individual methods, achieving 0.90 HR-30 and 0.70 MRR. RF performed better than E5 on all metrics over 50 trials (P less than 0.001) and achieved an average HR 30 of 0.98 and MRR of 0.73. LLM-derived features contributed most to RF's performance. One major cause of errors in automatic variable matching was ambiguous variable definitions within data dictionaries.

Large Language Models (LLMs) excel in data synthesis but can be inaccurate in domain-specific tasks, which retrieval-augmented generation (RAG) systems address by leveraging user-provided data. However, RAGs require optimization in both retrieval and generation stages, which can affect output quality. In this paper, we present LLM-Ref, a writing assistant tool that aids researchers in writing articles from multiple source documents with enhanced reference synthesis and handling capabilities. Unlike traditional RAG systems that use chunking and indexing, our tool retrieves and generates content directly from text paragraphs. This method facilitates direct reference extraction from the generated outputs, a feature unique to our tool. Additionally, our tool employs iterative response generation, effectively managing lengthy contexts within the language model's constraints. Compared to baseline RAG-based systems, our approach achieves a $3.25\times$ to $6.26\times$ increase in Ragas score, a comprehensive metric that provides a holistic view of a RAG system's ability to produce accurate, relevant, and contextually appropriate responses. This improvement shows our method enhances the accuracy and contextual relevance of writing assistance tools.

Counterfactual explanations can be used to interpret and debug text classifiers by producing minimally altered text inputs that change a classifier's output. In this work, we evaluate five methods for generating counterfactual explanations for a BERT text classifier on two datasets using three evaluation metrics. The results of our experiments suggest that established white-box substitution-based methods are effective at generating valid counterfactuals that change the classifier's output. In contrast, newer methods based on large language models (LLMs) excel at producing natural and linguistically plausible text counterfactuals but often fail to generate valid counterfactuals that alter the classifier's output. Based on these results, we recommend developing new counterfactual explanation methods that combine the strengths of established gradient-based approaches and newer LLM-based techniques to generate high-quality, valid, and plausible text counterfactual explanations.

Emotional text-to-speech (TTS) technology has achieved significant progress in recent years; however, challenges remain owing to the inherent complexity of emotions and limitations of the available emotional speech datasets and models. Previous studies typically relied on limited emotional speech datasets or required extensive manual annotations, restricting their ability to generalize across different speakers and emotional styles. In this paper, we present EmoSphere++, an emotion-controllable zero-shot TTS model that can control emotional style and intensity to resemble natural human speech. We introduce a novel emotion-adaptive spherical vector that models emotional style and intensity without human annotation. Moreover, we propose a multi-level style encoder that can ensure effective generalization for both seen and unseen speakers. We also introduce additional loss functions to enhance the emotion transfer performance for zero-shot scenarios. We employ a conditional flow matching-based decoder to achieve high-quality and expressive emotional TTS in a few sampling steps. Experimental results demonstrate the effectiveness of the proposed framework.

Contrastive Language-Image Pretraining (CLIP) models maximize the mutual information between text and visual modalities to learn representations. This makes the nature of the training data a significant factor in the efficacy of CLIP for downstream tasks. However, the lack of compositional diversity in contemporary image-text datasets limits the compositional reasoning ability of CLIP. We show that generating ``hard'' negative captions via in-context learning and synthesizing corresponding negative images with text-to-image generators offers a solution. We introduce a novel contrastive pre-training strategy that leverages these hard negative captions and images in an alternating fashion to train CLIP. We demonstrate that our method, named TripletCLIP, when applied to existing datasets such as CC3M and CC12M, enhances the compositional capabilities of CLIP, resulting in an absolute improvement of over 9% on the SugarCrepe benchmark on an equal computational budget, as well as improvements in zero-shot image classification and image retrieval. Our code, models, and data are available at: https://tripletclip.github.io

We explore optimally training protein language models, an area of significant interest in biological research where guidance on best practices is limited. Most models are trained with extensive compute resources until performance gains plateau, focusing primarily on increasing model sizes rather than optimizing the efficient compute frontier that balances performance and compute budgets. Our investigation is grounded in a massive dataset consisting of 939 million protein sequences. We trained over 300 models ranging from 3.5 million to 10.7 billion parameters on 5 to 200 billion unique tokens, to investigate the relations between model sizes, training token numbers, and objectives. First, we observed the effect of diminishing returns for the Causal Language Model (CLM) and that of overfitting for the Masked Language Model~(MLM) when repeating the commonly used Uniref database. To address this, we included metagenomic protein sequences in the training set to increase the diversity and avoid the plateau or overfitting effects. Second, we obtained the scaling laws of CLM and MLM on Transformer, tailored to the specific characteristics of protein sequence data. Third, we observe a transfer scaling phenomenon from CLM to MLM, further demonstrating the effectiveness of transfer through scaling behaviors based on estimated Effectively Transferred Tokens. Finally, to validate our scaling laws, we compare the large-scale versions of ESM-2 and PROGEN2 on downstream tasks, encompassing evaluations of protein generation as well as structure- and function-related tasks, all within less or equivalent pre-training compute budgets.

Designing and displaying haptic signals with sensory and emotional attributes can improve the user experience in various applications. Free-form user language provides rich sensory and emotional information for haptic design (e.g., ``This signal feels smooth and exciting''), but little work exists on linking user descriptions to haptic signals (i.e., language grounding). To address this gap, we conducted a study where 12 users described the feel of 32 signals perceived on a surface haptics (i.e., electrovibration) display. We developed a computational pipeline using natural language processing (NLP) techniques, such as GPT-3.5 Turbo and word embedding methods, to extract sensory and emotional keywords and group them into semantic clusters (i.e., concepts). We linked the keyword clusters to haptic signal features (e.g., pulse count) using correlation analysis. The proposed pipeline demonstrates the viability of a computational approach to analyzing haptic experiences. We discuss our future plans for creating a predictive model of haptic experience.

Additionally, Zopf et al. [2] introduced The evaluation of layer importance in deep learning has been an Layer-wise Relevance Propagation (LRP), including its variants, active area of research, with significant implications for model to analyze the flow of information in complex neural networks, optimization and interpretability. Recently, large language models providing a more nuanced understanding of each layer's contribution (LLMs) have gained prominence across various domains, yet limited to the model's decisions. Furthermore, the work of Mencía studies have explored the functional importance and performance et al. [12] highlighted the significance of Contextual Importance contributions of individual layers within LLMs, especially from Measures(CIM), which integrate contextual information to dynamically the perspective of activation distribution. In this work, we propose evaluate the importance of each layer based on specific input the Activation Variance-Sparsity Score (AVSS), a novel metric conditions, thus overcoming the limitations of static assessment combining normalized activation variance and sparsity to assess methods. However, these approaches often struggle to fully capture each layer's contribution to model performance. By identifying and the intricate activation distributions and redundancy within large removing approximately the lowest 25% of layers based on AVSS, language models, limiting their effectiveness in identifying less we achieve over 90% of original model performance across tasks critical layers.

While language models have exceptional capabilities at text generation, they lack a natural inductive bias for emitting numbers and thus struggle in tasks involving reasoning over quantities, especially arithmetics. This has particular relevance in scientific datasets where combinations of text and numerical data are abundant. One fundamental limitation is the nature of the CE loss, which assumes a nominal (categorical) scale and thus cannot convey proximity between generated number tokens. As a remedy, we here present two versions of a number token loss. The first is based on an $L_p$ loss between the ground truth token value and the weighted sum of the predicted class probabilities. The second loss minimizes the Wasserstein-1 distance between the distribution of the predicted output probabilities and the ground truth distribution. These regression-like losses can easily be added to any language model and extend the CE objective during training. We compare the proposed schemes on a mathematics dataset against existing tokenization, encoding, and decoding schemes for improving number representation in language models. Our results reveal a significant improvement in numerical accuracy when equipping a standard T5 model with the proposed loss schemes.