LayerNorm is a critical component in modern large language models (LLMs) for stabilizing training and ensuring smooth optimization. However, it introduces significant challenges in mechanistic interpretability, outlier feature suppression, faithful signal propagation, and computational and communication complexity of private inference. This work explores desirable activation functions in normalization-free decoder-only LLMs. Contrary to the conventional preference for the GELU in transformer-based models, our empirical findings demonstrate an opposite trend-- ReLU significantly outperforms GELU in LayerNorm-free models, leading to an 8.2% perplexity improvement. We discover a key issue with GELU, where early layers experience entropic overload, leading to the under-utilization of the representational capacity of attention heads. This highlights that smoother activations like GELU are ill-suited for LayerNorm-free architectures, whereas ReLU's geometrical properties--specialization in input space and intra-class selectivity--lead to improved learning dynamics and better information retention in the absence of LayerNorm. This study offers key insights for optimizing transformer architectures where LayerNorm introduces significant challenges. The code and implementation are available at relu-revival-normfree.

Pretraining molecular representations is crucial for drug and material discovery. Recent methods focus on learning representations from geometric structures, effectively capturing 3D position information. Yet, they overlook the rich information in biomedical texts, which detail molecules' properties and substructures. With this in mind, we set up a data collection effort for 200K pairs of ground-state geometric structures and biomedical texts, resulting in a PubChem3D dataset. Based on this dataset, we propose the GeomCLIP framework to enhance for multi-modal representation learning from molecular structures and biomedical text. During pre-training, we design two types of tasks, i.e., multimodal representation alignment and unimodal denoising pretraining, to align the 3D geometric encoder with textual information and, at the same time, preserve its original representation power. Experimental results show the effectiveness of GeomCLIP in various tasks such as molecular property prediction, zero-shot text-molecule retrieval, and 3D molecule captioning. Our code and collected dataset are available at \url{https://github.com/xiaocui3737/GeomCLIP}

In the aftermath of the COVID-19 pandemic and amid accelerating climate change, emerging infectious diseases, particularly those arising from zoonotic spillover, remain a global threat. Mpox (caused by the monkeypox virus) is a notable example of a zoonotic infection that often goes undiagnosed, especially as its rash progresses through stages, complicating detection across diverse populations with different presentations. In August 2024, the WHO Director-General declared the mpox outbreak a public health emergency of international concern for a second time. Despite the deployment of deep learning techniques for detecting diseases from skin lesion images, a robust and publicly accessible foundation model for mpox diagnosis is still lacking due to the unavailability of open-source mpox skin lesion images, multimodal clinical data, and specialized training pipelines. To address this gap, we propose MpoxVLM, a vision-language model (VLM) designed to detect mpox by analyzing both skin lesion images and patient clinical information. MpoxVLM integrates the CLIP visual encoder, an enhanced Vision Transformer (ViT) classifier for skin lesions, and LLaMA-2-7B models, pre-trained and fine-tuned on visual instruction-following question-answer pairs from our newly released mpox skin lesion dataset. Our work achieves 90.38% accuracy for mpox detection, offering a promising pathway to improve early diagnostic accuracy in combating mpox.

Large Language Models (LLMs) have demonstrated strong performance as knowledge repositories, enabling models to understand user queries and generate accurate and context-aware responses. Extensive evaluation setups have corroborated the positive correlation between the retrieval capability of LLMs and the frequency of entities in their pretraining corpus. We take the investigation further by conducting a comprehensive analysis of the internal reasoning and retrieval mechanisms of LLMs. Our work focuses on three critical dimensions -- the impact of entity popularity, the models' sensitivity to lexical variations in query formulation, and the progression of hidden state representations across LLM layers. Our preliminary findings reveal that popular questions facilitate early convergence of internal states toward the correct answer. However, as the popularity of a query increases, retrieved attributes across lexical variations become increasingly dissimilar and less accurate. Interestingly, we find that LLMs struggle to disentangle facts, grounded in distinct relations, from their parametric memory when dealing with highly popular subjects. Through a case study, we explore these latent strains within LLMs when processing highly popular queries, a phenomenon we term information anxiety. The emergence of information anxiety in LLMs underscores the adversarial injection in the form of linguistic variations and calls for a more holistic evaluation of frequently occurring entities.

In this survey, we introduce Meta-Black-Box-Optimization~(MetaBBO) as an emerging avenue within the Evolutionary Computation~(EC) community, which incorporates Meta-learning approaches to assist automated algorithm design. Despite the success of MetaBBO, the current literature provides insufficient summaries of its key aspects and lacks practical guidance for implementation. To bridge this gap, we offer a comprehensive review of recent advances in MetaBBO, providing an in-depth examination of its key developments. We begin with a unified definition of the MetaBBO paradigm, followed by a systematic taxonomy of various algorithm design tasks, including algorithm selection, algorithm configuration, solution manipulation, and algorithm generation. Further, we conceptually summarize different learning methodologies behind current MetaBBO works, including reinforcement learning, supervised learning, neuroevolution, and in-context learning with Large Language Models. A comprehensive evaluation of the latest representative MetaBBO methods is then carried out, alongside an experimental analysis of their optimization performance, computational efficiency, and generalization ability. Based on the evaluation results, we meticulously identify a set of core designs that enhance the generalization and learning effectiveness of MetaBBO. Finally, we outline the vision for the field by providing insight into the latest trends and potential future directions. Relevant literature will be continuously collected and updated at \url{https://github.com/GMC-DRL/Awesome-MetaBBO}.

Several GenAI coding assistants, including GitHub's Copilot [45], Tabnine [119], Codeium [24], and Cody [25], as well as general purpose tools such as ChatGPT [100], Claude [11], and Gemini [42], have become readily accessible, either as IDE extensions or standalone applications, enabling developers to perform many coding tasks with little effort, including automated code completion, summarization, and debugging.

We present a novel digital humanities method for representing our Twitch chatters as user embeddings created by a large language model (LLM). We cluster these embeddings automatically using affinity propagation and further narrow this clustering down through manual analysis. We analyze the chat of one stream by each Twitch streamer: SmallAnt, DougDoug and PointCrow. Our findings suggest that each streamer has their own type of chatters, however two categories emerge for all of the streamers: supportive viewers and emoji and reaction senders. Repetitive message spammers is a shared chatter category for two of the streamers.

With the rapid development of evaluation datasets to assess LLMs understanding across a wide range of subjects and domains, identifying a suitable language understanding benchmark has become increasingly challenging. In this work, we explore LLM evaluation challenges for low-resource language understanding and introduce ProverbEval, LLM evaluation benchmark for low-resource languages based on proverbs to focus on low-resource language understanding in culture-specific scenarios. We benchmark various LLMs and explore factors that create variability in the benchmarking process. We observed performance variances of up to 50%, depending on the order in which answer choices were presented in multiple-choice tasks. Native language proverb descriptions significantly improve tasks such as proverb generation, contributing to improved outcomes. Additionally, monolingual evaluations consistently outperformed their cross-lingual counterparts. We argue special attention must be given to the order of choices, choice of prompt language, task variability, and generation tasks when creating LLM evaluation benchmarks.

Data contamination presents a critical barrier preventing widespread industrial adoption of advanced software engineering techniques that leverage code language models (CLMs). This phenomenon occurs when evaluation data inadvertently overlaps with the public code repositories used to train CLMs, severely undermining the credibility of performance evaluations. For software companies considering the integration of CLM-based techniques into their development pipeline, this uncertainty about true performance metrics poses an unacceptable business risk. Code refactoring, which comprises code restructuring and variable renaming, has emerged as a promising measure to mitigate data contamination. It provides a practical alternative to the resource-intensive process of building contamination-free evaluation datasets, which would require companies to collect, clean, and label code created after the CLMs' training cutoff dates. However, the lack of automated code refactoring tools and scientifically validated refactoring techniques has hampered widespread industrial implementation. To bridge the gap, this paper presents the first systematic study to examine the efficacy of code refactoring operators at multiple scales (method-level, class-level, and cross-class level) and in different programming languages. In particular, we develop an open-sourced toolkit, CODECLEANER, which includes 11 operators for Python, with nine method-level, one class-level, and one cross-class-level operator. A drop of 65% overlap ratio is found when applying all operators in CODECLEANER, demonstrating their effectiveness in addressing data contamination. Additionally, we migrate four operators to Java, showing their generalizability to another language. We make CODECLEANER online available to facilitate further studies on mitigating CLM data contamination.

Elon Musk has expanded his lawsuit against the ChatGPT maker OpenAI, adding federal antitrust and other claims and adding OpenAI's largest financial backer, Microsoft, as a defendant. Musk's amended lawsuit, filed on Thursday night in federal court in Oakland, California, said Microsoft and OpenAI illegally sought to monopolize the market for generative artificial intelligence and sideline competitors. Like Musk's original August complaint, it accused OpenAI and its chief executive, Samuel Altman, of violating contract provisions by putting profits ahead of the public good in the push to advance AI. "Never before has a corporation gone from tax-exempt charity to a 157bn for-profit, market-paralyzing gorgon – and in just eight years," the complaint said. It seeks to void OpenAI's license with Microsoft and force them to divest "ill-gotten" gains. OpenAI in a statement said the latest lawsuit "is even more baseless and overreaching than the previous ones".