Due to the rise of privacy concerns, in many practical applications the training data is aggregated before being shared with the learner, in order to protect privacy of users' sensitive responses. In an aggregate learning framework, the dataset is grouped into bags of samples, where each bag is available only with an aggregate response, providing a summary of individuals' responses in that bag. In this paper, we study two natural loss functions for learning from aggregate responses: bag-level loss and the instance-level loss. In the former, the model is learnt by minimizing a loss between aggregate responses and aggregate model predictions, while in the latter the model aims to fit individual predictions to the aggregate responses. In this work, we show that the instance-level loss can be perceived as a regularized form of the bag-level loss. This observation lets us compare the two approaches with respect to bias and variance of the resulting estimators, and introduce a novel interpolating estimator which combines the two approaches. For linear regression tasks, we provide a precise characterization of the risk of the interpolating estimator in an asymptotic regime where the size of the training set grows in proportion to the features dimension. Our analysis allows us to theoretically understand the effect of different factors, such as bag size on the model prediction risk. In addition, we propose a mechanism for differentially private learning from aggregate responses and derive the optimal bag size in terms of prediction risk-privacy trade-off. We also carry out thorough experiments to corroborate our theory and show the efficacy of the interpolating estimator.

We study federated unlearning, a novel problem to eliminate the impact of specific clients or data points on the global model learned via federated learning (FL). This problem is driven by the right to be forgotten and the privacy challenges in FL. We introduce a new framework for exact federated unlearning that meets two essential criteria: \textit{communication efficiency} and \textit{exact unlearning provability}. To our knowledge, this is the first work to tackle both aspects coherently. We start by giving a rigorous definition of \textit{exact} federated unlearning, which guarantees that the unlearned model is statistically indistinguishable from the one trained without the deleted data. We then pinpoint the key property that enables fast exact federated unlearning: total variation (TV) stability, which measures the sensitivity of the model parameters to slight changes in the dataset. Leveraging this insight, we develop a TV-stable FL algorithm called \texttt{FATS}, which modifies the classical \texttt{\underline{F}ed\underline{A}vg} algorithm for \underline{T}V \underline{S}tability and employs local SGD with periodic averaging to lower the communication round. We also design efficient unlearning algorithms for \texttt{FATS} under two settings: client-level and sample-level unlearning. We provide theoretical guarantees for our learning and unlearning algorithms, proving that they achieve exact federated unlearning with reasonable convergence rates for both the original and unlearned models. We empirically validate our framework on 6 benchmark datasets, and show its superiority over state-of-the-art methods in terms of accuracy, communication cost, computation cost, and unlearning efficacy.

Speaker embeddings carry valuable emotion-related information, which makes them a promising resource for enhancing speech emotion recognition (SER), especially with limited labeled data. Traditionally, it has been assumed that emotion information is indirectly embedded within speaker embeddings, leading to their under-utilization. Our study reveals a direct and useful link between emotion and state-of-the-art speaker embeddings in the form of intra-speaker clusters. By conducting a thorough clustering analysis, we demonstrate that emotion information can be readily extracted from speaker embeddings. In order to leverage this information, we introduce a novel contrastive pretraining approach applied to emotion-unlabeled data for speech emotion recognition. The proposed approach involves the sampling of positive and the negative examples based on the intra-speaker clusters of speaker embeddings. The proposed strategy, which leverages extensive emotion-unlabeled data, leads to a significant improvement in SER performance, whether employed as a standalone pretraining task or integrated into a multi-task pretraining setting.

Variational families with full-rank covariance approximations are known not to work well in black-box variational inference (BBVI), both empirically and theoretically. In fact, recent computational complexity results for BBVI have established that full-rank variational families scale poorly with the dimensionality of the problem compared to e.g. mean field families. This is particularly critical to hierarchical Bayesian models with local variables; their dimensionality increases with the size of the datasets. Consequently, one gets an iteration complexity with an explicit $\mathcal{O}(N^2)$ dependence on the dataset size $N$. In this paper, we explore a theoretical middle ground between mean-field variational families and full-rank families: structured variational families. We rigorously prove that certain scale matrix structures can achieve a better iteration complexity of $\mathcal{O}(N)$, implying better scaling with respect to $N$. We empirically verify our theoretical results on large-scale hierarchical models.

In order to efficiently explore the chemical space of all possible small molecules, a common approach is to compress the dimension of the system to facilitate downstream machine learning tasks. Towards this end, we present a data driven approach for clustering potential energy landscapes of molecular structures by applying recently developed Network Embedding techniques, to obtain latent variables defined through the embedding function. To scale up the method, we also incorporate an entropy sensitive adaptive scheme for hierarchical sampling of the energy landscape, based on Metadynamics and Transition Path Theory. By taking into account the kinetic information implied by a system's energy landscape, we are able to interpret dynamical node-node relationships in reduced dimensions. We demonstrate the framework through Lennard-Jones (LJ) clusters and a human DNA sequence.

Bayesian Optimization (BO) is a powerful method for optimizing black-box functions by combining prior knowledge with ongoing function evaluations. BO constructs a probabilistic surrogate model of the objective function given the covariates, which is in turn used to inform the selection of future evaluation points through an acquisition function. For smooth continuous search spaces, Gaussian Processes (GPs) are commonly used as the surrogate model as they offer analytical access to posterior predictive distributions, thus facilitating the computation and optimization of acquisition functions. However, in complex scenarios involving optimizations over categorical or mixed covariate spaces, GPs may not be ideal. This paper introduces Simulation Based Bayesian Optimization (SBBO) as a novel approach to optimizing acquisition functions that only requires \emph{sampling-based} access to posterior predictive distributions. SBBO allows the use of surrogate probabilistic models tailored for combinatorial spaces with discrete variables. Any Bayesian model in which posterior inference is carried out through Markov chain Monte Carlo can be selected as the surrogate model in SBBO. In applications involving combinatorial optimization, we demonstrate empirically the effectiveness of SBBO method using various choices of surrogate models.

Objective: The objective of this work is to introduce and demonstrate the effectiveness of a novel sensing modality for contact detection between an off-the-shelf aspiration catheter and a thrombus. Methods: A custom robotic actuator with a pressure sensor was used to generate an oscillatory vacuum excitation and sense the pressure inside the extracorporeal portion of the catheter. Vacuum pressure profiles and robotic motion data were used to train a support vector machine (SVM) classification model to detect contact between the aspiration catheter tip and a mock thrombus. Validation consisted of benchtop accuracy verification, as well as user study comparison to the current standard of angiographic presentation. Results: Benchtop accuracy of the sensing modality was shown to be 99.67%. The user study demonstrated statistically significant improvement in identifying catheter-thrombus contact compared to the current standard. The odds ratio of successful detection of clot contact was 2.86 (p=0.03) when using the proposed sensory method compared to without it. Conclusion: The results of this work indicate that the proposed sensing modality can offer intraoperative feedback to interventionalists that can improve their ability to detect contact between the distal tip of a catheter and a thrombus. Significance: By offering a relatively low-cost technology that affords off-the-shelf aspiration catheters as clot-detecting sensors, interventionalists can improve the first-pass effect of the mechanical thrombectomy procedure while reducing procedural times and mental burden.

Training neural networks with first order optimisation methods is at the core of the empirical success of deep learning. The scale of initialisation is a crucial factor, as small initialisations are generally associated to a feature learning regime, for which gradient descent is implicitly biased towards simple solutions. This work provides a general and quantitative description of the early alignment phase, originally introduced by Maennel et al. (2018) . For small initialisation and one hidden ReLU layer networks, the early stage of the training dynamics leads to an alignment of the neurons towards key directions. This alignment induces a sparse representation of the network, which is directly related to the implicit bias of gradient flow at convergence. This sparsity inducing alignment however comes at the expense of difficulties in minimising the training objective: we also provide a simple data example for which overparameterised networks fail to converge towards global minima and only converge to a spurious stationary point instead.

This study explores the crucial interplay between aggregators and building occupants in activating flexibility through Demand Response (DR) programs, with a keen focus on achieving robust decarbonization and fortifying the resilience of the energy system amidst the uncertainties presented by Renewable Energy Sources (RES). Firstly, it introduces a methodology of optimizing aggregated flexibility provision strategies in environments with limited data, utilizing Discrete Fourier Transformation (DFT) and clustering techniques to identify building occupant's activity patterns. Secondly, the study assesses the disaggregated flexibility provision of Heating Ventilation and Air Conditioning (HVAC) systems during DR events, employing machine learning and optimization techniques for precise, device-level analysis. The first approach offers a non-intrusive pathway for aggregators to provide flexibility services in environments of a single smart meter for the whole building's consumption, while the second approach carefully considers building occupants' thermal comfort profiles, while maximizing flexibility in case of existence of dedicated smart meters to the HVAC systems. Through the application of data-driven techniques and encompassing case studies from both industrial and residential buildings, this paper not only unveils pivotal opportunities for aggregators in the balancing and emerging flexibility markets but also successfully develops end-to-end practical tools for aggregators. Furthermore, the efficacy of this tool is validated through detailed case studies, substantiating its operational capability and contributing to the evolution of a resilient and efficient energy system.

Neural network with quadratic decision functions have been introduced as alternatives to standard neural networks with affine linear one. They are advantageous when the objects to be identified are of compact basic geometries like circles, ellipsis etc. In this paper we investigate the use of such ansatz functions for classification. In particular we test and compare the algorithm on the MNIST dataset for classification of handwritten digits and for classification of subspecies. We also show, that the implementation can be based on the neural network structure in the software Tensorflow and Keras, respectively.