Histopathology plays a central role in clinical medicine and biomedical research. While artificial intelligence shows promising results on many pathological tasks, generalization and dealing with rare diseases, where training data is scarce, remains a challenge. Distilling knowledge from unlabeled data into a foundation model before learning from, potentially limited, labeled data provides a viable path to address these challenges. In this work, we extend the state of the art of foundation models for digital pathology whole slide images by semi-automated data curation and incorporating pathologist domain knowledge. Specifically, we combine computational and pathologist domain knowledge (1) to curate a diverse dataset of 103k slides corresponding to 750 million image patches covering data from different fixation, staining, and scanning protocols as well as data from different indications and labs across the EU and US, (2) for grouping semantically similar slides and tissue patches, and (3) to augment the input images during training. We evaluate the resulting model on a set of public and internal benchmarks and show that although our foundation model is trained with an order of magnitude less slides, it performs on par or better than competing models. We expect that scaling our approach to more data and larger models will further increase its performance and capacity to deal with increasingly complex real world tasks in diagnostics and biomedical research.

Image-text retrieval has developed rapidly in recent years. However, it is still a challenge in remote sensing due to visual-semantic imbalance, which leads to incorrect matching of non-semantic visual and textual features. To solve this problem, we propose a novel Direction-Oriented Visual-semantic Embedding Model (DOVE) to mine the relationship between vision and language. Our highlight is to conduct visual and textual representations in latent space, directing them as close as possible to a redundancy-free regional visual representation. Concretely, a Regional-Oriented Attention Module (ROAM) adaptively adjusts the distance between the final visual and textual embeddings in the latent semantic space, oriented by regional visual features. Meanwhile, a lightweight Digging Text Genome Assistant (DTGA) is designed to expand the range of tractable textual representation and enhance global word-level semantic connections using less attention operations. Ultimately, we exploit a global visual-semantic constraint to reduce single visual dependency and serve as an external constraint for the final visual and textual representations. The effectiveness and superiority of our method are verified by extensive experiments including parameter evaluation, quantitative comparison, ablation studies and visual analysis, on two benchmark datasets, RSICD and RSITMD.

Heightened AI expectations facilitate performance in human-AI interactions through placebo effects. While lowering expectations to control for placebo effects is advisable, overly negative expectations could induce nocebo effects. In a letter discrimination task, we informed participants that an AI would either increase or decrease their performance by adapting the interface, but in reality, no AI was present in any condition. A Bayesian analysis showed that participants had high expectations and performed descriptively better irrespective of the AI description when a sham-AI was present. Using cognitive modeling, we could trace this advantage back to participants gathering more information. A replication study verified that negative AI descriptions do not alter expectations, suggesting that performance expectations with AI are biased and robust to negative verbal descriptions. We discuss the impact of user expectations on AI interactions and evaluation and provide a behavioral placebo marker for human-AI interaction

Phylogenetics is now fundamental in life sciences, providing insights into the earliest branches of life and the origins and spread of epidemics. However, finding suitable phylogenies from the vast space of possible trees remains challenging. To address this problem, for the first time, we perform both tree exploration and inference in a continuous space where the computation of gradients is possible. This continuous relaxation allows for major leaps across tree space in both rooted and unrooted trees, and is less susceptible to convergence to local minima. Our approach outperforms the current best methods for inference on unrooted trees and, in simulation, accurately infers the tree and root in ultrametric cases. The approach is effective in cases of empirical data with negligible amounts of data, which we demonstrate on the phylogeny of jawed vertebrates. Indeed, only a few genes with an ultrametric signal were generally sufficient for resolving the major lineages of vertebrates. Optimisation is possible via automatic differentiation and our method presents an effective way forwards for exploring the most difficult, data-deficient phylogenetic questions.

Few-shot hyperspectral image classification aims to identify the classes of each pixel in the images by only marking few of these pixels. And in order to obtain the spatial-spectral joint features of each pixel, the fixed-size patches centering around each pixel are often used for classification. However, observing the classification results of existing methods, we found that boundary patches corresponding to the pixels which are located at the boundary of the objects in the hyperspectral images, are hard to classify. These boundary patchs are mixed with multi-class spectral information. Inspired by this, we propose to augment the prototype network with TransMix for few-shot hyperspectrial image classification(APNT). While taking the prototype network as the backbone, it adopts the transformer as feature extractor to learn the pixel-to-pixel relation and pay different attentions to different pixels. At the same time, instead of directly using the patches which are cut from the hyperspectral images for training, it randomly mixs up two patches to imitate the boundary patches and uses the synthetic patches to train the model, with the aim to enlarge the number of hard training samples and enhance their diversity. And by following the data agumentation technique TransMix, the attention returned by the transformer is also used to mix up the labels of two patches to generate better labels for synthetic patches. Compared with existing methods, the proposed method has demonstrated sate of the art performance and better robustness for few-shot hyperspectral image classification in our experiments.

This study presents a comprehensive overview of PIML techniques in the context of condition monitoring. The central concept driving PIML is the incorporation of known physical laws and constraints into machine learning algorithms, enabling them to learn from available data while remaining consistent with physical principles. Through fusing domain knowledge with data-driven learning, PIML methods offer enhanced accuracy and interpretability in comparison to purely data-driven approaches. In this comprehensive survey, detailed examinations are performed with regard to the methodology by which known physical principles are integrated within machine learning frameworks, as well as their suitability for specific tasks within condition monitoring. Incorporation of physical knowledge into the ML model may be realized in a variety of methods, with each having its unique advantages and drawbacks. The distinct advantages and limitations of each methodology for the integration of physics within data-driven models are detailed, considering factors such as computational efficiency, model interpretability, and generalizability to different systems in condition monitoring and fault detection. Several case studies and works of literature utilizing this emerging concept are presented to demonstrate the efficacy of PIML in condition monitoring applications. From the literature reviewed, the versatility and potential of PIML in condition monitoring may be demonstrated. Novel PIML methods offer an innovative solution for addressing the complexities of condition monitoring and associated challenges. This comprehensive survey helps form the foundation for future work in the field. As the technology continues to advance, PIML is expected to play a crucial role in enhancing maintenance strategies, system reliability, and overall operational efficiency in engineering systems.

This paper presents a structure-preserving Bayesian approach for learning nonseparable Hamiltonian systems using stochastic dynamic models allowing for statistically-dependent, vector-valued additive and multiplicative measurement noise. The approach is comprised of three main facets. First, we derive a Gaussian filter for a statistically-dependent, vector-valued, additive and multiplicative noise model that is needed to evaluate the likelihood within the Bayesian posterior. Second, we develop a novel algorithm for cost-effective application of Bayesian system identification to high-dimensional systems. Third, we demonstrate how structure-preserving methods can be incorporated into the proposed framework, using nonseparable Hamiltonians as an illustrative system class. We compare the Bayesian method to a state-of-the-art machine learning method on a canonical nonseparable Hamiltonian model and a chaotic double pendulum model with small, noisy training datasets. The results show that using the Bayesian posterior as a training objective can yield upwards of 724 times improvement in Hamiltonian mean squared error using training data with up to 10% multiplicative noise compared to a standard training objective. Lastly, we demonstrate the utility of the novel algorithm for parameter estimation of a 64-dimensional model of the spatially-discretized nonlinear Schr\"odinger equation with data corrupted by up to 20% multiplicative noise.

Consider the nonparametric logistic regression problem. In the logistic regression, we usually consider the maximum likelihood estimator, and the excess risk is the expectation of the Kullback-Leibler (KL) divergence between the true and estimated conditional class probabilities. However, in the nonparametric logistic regression, the KL divergence could diverge easily, and thus, the convergence of the excess risk is difficult to prove or does not hold. Several existing studies show the convergence of the KL divergence under strong assumptions. In most cases, our goal is to estimate the true conditional class probabilities. Thus, instead of analyzing the excess risk itself, it suffices to show the consistency of the maximum likelihood estimator in some suitable metric. In this paper, using a simple unified approach for analyzing the nonparametric maximum likelihood estimator (NPMLE), we directly derive the convergence rates of the NPMLE in the Hellinger distance under mild assumptions. Although our results are similar to the results in some existing studies, we provide simple and more direct proofs for these results. As an important application, we derive the convergence rates of the NPMLE with deep neural networks and show that the derived rate nearly achieves the minimax optimal rate.

Recent innovations in transformers have shown their superior performance in natural language processing (NLP) and computer vision (CV). The ability to capture long-range dependencies and interactions in sequential data has also triggered a great interest in time series modeling, leading to the widespread use of transformers in many time series applications. However, being the most common and crucial application, the adaptation of transformers to time series forecasting has remained limited, with both promising and inconsistent results. In contrast to the challenges in NLP and CV, time series problems not only add the complexity of order or temporal dependence among input sequences but also consider trend, level, and seasonality information that much of this data is valuable for decision making. The conventional training scheme has shown deficiencies regarding model overfitting, data scarcity, and privacy issues when working with transformers for a forecasting task. In this work, we propose attentive federated transformers for time series stock forecasting with better performance while preserving the privacy of participating enterprises. Empirical results on various stock data from the Yahoo! Finance website indicate the superiority of our proposed scheme in dealing with the above challenges and data heterogeneity in federated learning.

New York City (NYC) topped the global chart for the worst air pollution in June 2023, owing to the wildfire smoke drifting in from Canada. This unprecedented situation caused significant travel disruptions and shifts in traditional activity patterns of NYC residents. This study utilized large-scale social media data to study different crisis activity concerns (i.e., evacuation, staying indoors, shopping, and recreational activities among others) in the emergence of the 2023 Canadian wildfire smoke in NYC. In this regard, one week (June 02 through June 09, 2023) geotagged Twitter data from NYC were retrieved and used in the analysis. The tweets were processed using advanced text classification techniques and later integrated with national databases such as Social Security Administration data, Census, and American Community Survey. Finally, a model has been developed to make community inferences of different activity concerns in a major wildfire. The findings suggest, during wildfires, females are less likely to engage in discussions about evacuation, trips for medical, social, or recreational purposes, and commuting for work, likely influenced by workplaces maintaining operations despite poor air quality. There were also racial disparities in these discussions, with Asians being more likely than Hispanics to discuss evacuation and work commute, and African Americans being less likely to discuss social and recreational activities. Additionally, individuals from low-income neighborhoods and non-higher education students expressed fewer concerns about evacuation. This study provides valuable insights for policymakers, emergency planners, and public health officials, aiding them in formulating targeted communication strategies and equitable emergency response plans.