Recently introduced prior-encoding deep generative models (e.g., PriorVAE, $\pi$VAE, and PriorCVAE) have emerged as powerful tools for scalable Bayesian inference by emulating complex stochastic processes like Gaussian processes (GPs). However, these methods remain largely a proof-of-concept and inaccessible to practitioners. We propose DeepRV, a lightweight, decoder-only approach that accelerates training, and enhances real-world applicability in comparison to current VAE-based prior encoding approaches. Leveraging probabilistic programming frameworks (e.g., NumPyro) for inference, DeepRV achieves significant speedups while also improving the quality of parameter inference, closely matching full MCMC sampling. We showcase its effectiveness in process emulation and spatial analysis of the UK using simulated data, gender-wise cancer mortality rates for individuals under 50, and HIV prevalence in Zimbabwe. To bridge the gap between theory and practice, we provide a user-friendly API, enabling scalable and efficient Bayesian inference.

With the widespread adoption of Ethereum, financial frauds such as Ponzi schemes have become increasingly rampant in the blockchain ecosystem, posing significant threats to the security of account assets. Existing Ethereum fraud detection methods typically model account transactions as graphs, but this approach primarily focuses on binary transactional relationships between accounts, failing to adequately capture the complex multi-party interaction patterns inherent in Ethereum. To address this, we propose a hypergraph modeling method for the Ponzi scheme detection method in Ethereum, called HyperDet. Specifically, we treat transaction hashes as hyperedges that connect all the relevant accounts involved in a transaction. Additionally, we design a two-step hypergraph sampling strategy to significantly reduce computational complexity. Furthermore, we introduce a dual-channel detection module, including the hypergraph detection channel and the hyper-homo graph detection channel, to be compatible with existing detection methods. Experimental results show that, compared to traditional homogeneous graph-based methods, the hyper-homo graph detection channel achieves significant performance improvements, demonstrating the superiority of hypergraph in Ponzi scheme detection. This research offers innovations for modeling complex relationships in blockchain data.

Score-based or diffusion models generate high-quality tabular data, surpassing GAN-based and VAE-based models. However, these methods require substantial training time. In this paper, we introduce RecTable, which uses the rectified flow modeling, applied in such as text-to-image generation and text-to-video generation. RecTable features a simple architecture consisting of a few stacked gated linear unit blocks. Additionally, our training strategies are also simple, incorporating a mixed-type noise distribution and a logit-normal timestep distribution. Our experiments demonstrate that RecTable achieves competitive performance compared to the several state-of-the-art diffusion and score-based models while reducing the required training time. Our code is available at https://github.com/fmp453/rectable.

Maritime AIS (Automatic Identification Systems) data serve as a valuable resource for studying vessel behavior. This study proposes a methodology to analyze route between maritime points of interest and extract geo-referenced standard routes, as maritime patterns of life, from raw AIS data. The underlying assumption is that ships adhere to consistent patterns when travelling in certain maritime areas due to geographical, environmental, or economic factors. Deviations from these patterns may be attributed to weather conditions, seasonality, or illicit activities. This enables maritime surveillance authorities to analyze the navigational behavior between ports, providing insights on vessel route patterns, possibly categorized by vessel characteristics (type, flag, or size). Our methodological process begins by segmenting AIS data into distinct routes using a finite state machine (FSM), which describes routes as seg-ments connecting pairs of points of interest. The extracted segments are ag-gregated based on their departure and destination ports and then modelled using iterative density-based clustering to connect these ports. The cluster-ing parameters are assigned manually to sample and then extended to the en-tire dataset using linear regression. Overall, the approach proposed in this paper is unsupervised and does not require any ground truth to be trained. The approach has been tested on data on the on a six-year AIS dataset cover-ing the Arctic region and the Europe, Middle East, North Africa areas. The total size of our dataset is 1.15 Tbytes. The approach has proved effective in extracting standard routes, with less than 5% outliers, mostly due to routes with either their departure or their destination port not included in the test areas.

Gene expression datasets offer insights into gene regulation mechanisms, biochemical pathways, and cellular functions. Additionally, comparing gene expression profiles between disease and control patients can deepen the understanding of disease pathology. Therefore, machine learning has been used to process gene expression data, with patient diagnosis emerging as one of the most popular applications. Although gene expression data can provide valuable insights, challenges arise because the number of patients in expression datasets is usually limited, and the data from different datasets with different gene expressions cannot be easily combined. This work proposes a novel methodology to address these challenges by integrating multiple gene expression datasets and domain-specific knowledge using knowledge graphs, a unique tool for biomedical data integration. Then, vector representations are produced using knowledge graph embedding techniques, which are used as inputs for a graph neural network and a multi-layer perceptron. We evaluate the efficacy of our methodology in three settings: single-dataset learning, multi-dataset learning, and transfer learning. The experimental results show that combining gene expression datasets and domain-specific knowledge improves patient diagnosis in all three settings.

This process mirrors parallel developments in machine learning, where large language models ingest unstructured text by converting words into discrete tokens embedded within a high-dimensional vector space. This perspective explores how advances in understanding the structure of language embeddings can inform ongoing efforts to analyze and visualize single cell datasets. We discuss how the context of tokens influences the geometry of embedding space, and the role of low-dimensional manifolds in shaping this space's robustness and interpretability. We highlight new developments in language modeling, such as interpretability probes and in-context reasoning, that can inform future efforts to construct and consolidate cell atlases. The implicit goal of modern single-cell technologies is to decompile the cell--to abstract it away from its squishy context, and to render it as a single point in a high-dimensional vector space. But how do we know if this space is meaningful?

Privacy-preserving synthetic data offers a promising solution to harness segregated data in high-stakes domains where information is compartmentalized for regulatory, privacy, or institutional reasons. This survey provides a comprehensive framework for understanding the landscape of privacy-preserving synthetic data, presenting the theoretical foundations of generative models and differential privacy followed by a review of state-of-the-art methods across tabular data, images, and text. Our synthesis of evaluation approaches highlights the fundamental trade-off between utility for down-stream tasks and privacy guarantees, while identifying critical research gaps: the lack of realistic benchmarks representing specialized domains and insufficient empirical evaluations required to contextualise formal guarantees. Through empirical analysis of four leading methods on five real-world datasets from specialized domains, we demonstrate significant performance degradation under realistic privacy constraints ($\epsilon \leq 4$), revealing a substantial gap between results reported on general domain benchmarks and performance on domain-specific data. %Our findings highlight key challenges including unaccounted privacy leakage, insufficient empirical verification of formal guarantees, and a critical deficit of realistic benchmarks. These challenges underscore the need for robust evaluation frameworks, standardized benchmarks for specialized domains, and improved techniques to address the unique requirements of privacy-sensitive fields such that this technology can deliver on its considerable potential.

Algorithms for machine learning-guided design, or design algorithms, use machine learning-based predictions to propose novel objects with desired property values. Given a new design task -- for example, to design novel proteins with high binding affinity to a therapeutic target -- one must choose a design algorithm and specify any hyperparameters and predictive and/or generative models involved. How can these decisions be made such that the resulting designs are successful? This paper proposes a method for design algorithm selection, which aims to select design algorithms that will produce a distribution of design labels satisfying a user-specified success criterion -- for example, that at least ten percent of designs' labels exceed a threshold. It does so by combining designs' predicted property values with held-out labeled data to reliably forecast characteristics of the label distributions produced by different design algorithms, building upon techniques from prediction-powered inference. The method is guaranteed with high probability to return design algorithms that yield successful label distributions (or the null set if none exist), if the density ratios between the design and labeled data distributions are known. We demonstrate the method's effectiveness in simulated protein and RNA design tasks, in settings with either known or estimated density ratios.

-- Monitoring flowers over time is essential for precision robotic pollination in agriculture. T o accomplish this, a continuous spatial-temporal observation of plant growth can be done using stationary RGB-D cameras. However, image registration becomes a serious challenge due to changes in the visual appearance of the plant caused by the pollination process and occlusions from growth and camera angles. Plants flower in a manner that produces distinct clusters on branches. This paper presents a method for matching flower clusters using descriptors generated from RGB-D data and considers allowing for spatial uncertainty within the cluster . The proposed approach leverages the Unscented Transform to efficiently estimate plant descriptor uncertainty tolerances, enabling a robust image-registration process despite temporal changes. The Unscented Transform is used to handle the nonlinear transformations by propagating the uncertainty of flower positions to determine the variations in the descriptor domain. A Monte Carlo simulation is used to validate the Unscented Transform results, confirming our method's effectiveness for flower cluster matching. Therefore, it can facilitate improved robotics pollination in dynamic environments. Although global agriculture relies heavily on pollination, evidence has shown that the population of natural pollinators is decreasing, raising concerns about food and the economy [1].

Many methods have been proposed for removing batch effects and aligning single-cell RNA (scRNA) datasets. However, performance is typically evaluated based on multiple parameters and few datasets, creating challenges in assessing which method is best for aligning data at scale. Here, we introduce the K-Neighbors Intersection (KNI) score, a single score that both penalizes batch effects and measures accuracy at cross-dataset cell-type label prediction alongside carefully cu-rated small (scMARK) and large (scREF) benchmarks comprising 11 and 46 human scRNA studies respectively, where we have standardized author labels. Using the KNI score, we evaluate and optimize approaches for cross-dataset single-cell RNA integration. We introduce Batch Adversarial single-cell V ariational Inference (BA-scVI), as a new variant of scVI that uses adversarial training to penalize batch-effects in the encoder and decoder, and show this approach outperforms other methods. In the resulting aligned space, we find that the granularity of cell-type groupings is conserved, supporting the notion that whole-organism cell-type maps can be created by a single model without loss of information. To build comprehensive organism-wide and inter-species maps of cell types and states, we must build integrated transcriptional atlases that combine studies and patient populations at scale Regev et al. (2017). The now large number of published scRNA studies creates an opportunity for building a largely aligned scRNA atlas that would enable standardized reference-based analysis and cross-dataset comparison Lotfollahi et al. (2024). However, the challenge in combining data from disparate scRNA studies remains due to batch effects Lotfollahi et al. (2024); L ahnemann et al. (2020); Gavish et al. (2023). While studies have looked at the alignment of batches within datasets or between a handful of datasets focused on a specific tissue type, few have looked at model alignment across studies from different tissue types and instruments, as would be required for the generation of a reference atlas. Meanwhile, those studies that have used models to align datasets across tissue types and studies have used supervised models trained on cell-type labels, such as scBERT, Celltypist, SCimilarity, and SA TURN Y ang et al. (2022); Dom ınguez Conde et al. (2022); Heimberg et al. (2024); Rosen et al. (2024).