Sepsis is a major cause of ICU mortality, where early recognition and effective interventions are essential for improving patient outcomes. However, the vasoactive-inotropic score (VIS) varies dynamically with a patient's hemodynamic status, complicated by irregular medication patterns, missing data, and confounders, making sepsis prediction challenging. To address this, we propose a novel Teacher-Student multitask framework with self-supervised VIS pretraining via a Masked Autoencoder (MAE). The teacher model performs mortality classification and severity-score regression, while the student distills robust time-series representations, enhancing adaptation to heterogeneous VIS data. Compared to LSTM-based methods, our approach achieves an AUROC of 0.82 on MIMIC-IV 3.0 (9,476 patients), outperforming the baseline (0.74). SHAP analysis revealed that SOFA score (0.147) had the greatest impact on ICU mortality, followed by LODS (0.033), single marital status (0.031), and Medicaid insurance (0.023), highlighting the role of sociodemographic factors. SAPSII (0.020) also contributed significantly. These findings suggest that both clinical and social factors should be considered in ICU decision-making. Our novel multitask and distillation strategies enable earlier identification of high-risk patients, improving prediction accuracy and disease management, offering new tools for ICU decision support.

Analyzing Factors Influencing Driver Willingness to Accept Advanced Driver Assistance Systems Hannah Musau a,, Nana Kankam Gyimah a, Judith Mwakalonge a, Gurcan Comert b, Saidi Siuhi a a Department of Engineering, South Carolina State University, Orangeburg, South Carolina, USA, 29117 b Department of Computational Engineering and Data Science, North Carolina A&T State University, Greensboro, North Carolina, US, 27411Abstract Advanced Driver Assistance Systems (ADAS) enhance highway safety by improving environmental perception and reducing human errors. However, misconceptions, trust issues, and knowledge gaps hinder widespread adoption. This study examines driver perceptions, knowledge sources, and usage patterns of ADAS in passenger vehicles. A nationwide survey collected data from a diverse sample of U.S. drivers. Machine learning models predicted ADAS adoption, with SHAP (SHapley Additive Explanations) identifying key influencing factors. Findings indicate that higher trust levels correlate with increased ADAS usage, while concerns about reliability remain a barrier. Findings emphasize the influence of socioeconomic, demographic, and behavioral factors on ADAS adoption, offering guidance for automakers, policymakers, and safety advocates to improve awareness, trust, and usability. Introduction Human factors are the leading cause of road crashes, contributing to over 90% of incidents either alone or alongside failures in vehicles or infrastructure [1].

Sparse autoencoders (SAEs) are a popular method for interpreting concepts represented in large language model (LLM) activations. However, there is a lack of evidence regarding the validity of their interpretations due to the lack of a ground truth for the concepts used by an LLM, and a growing number of works have presented problems with current SAEs. One alternative source of evidence would be demonstrating that SAEs improve performance on downstream tasks beyond existing baselines. We test this by applying SAEs to the real-world task of LLM activation probing in four regimes: data scarcity, class imbalance, label noise, and covariate shift. Due to the difficulty of detecting concepts in these challenging settings, we hypothesize that SAEs' basis of interpretable, concept-level latents should provide a useful inductive bias. However, although SAEs occasionally perform better than baselines on individual datasets, we are unable to design ensemble methods combining SAEs with baselines that consistently outperform ensemble methods solely using baselines. Additionally, although SAEs initially appear promising for identifying spurious correlations, detecting poor dataset quality, and training multi-token probes, we are able to achieve similar results with simple non-SAE baselines as well. Though we cannot discount SAEs' utility on other tasks, our findings highlight the shortcomings of current SAEs and the need to rigorously evaluate interpretability methods on downstream tasks with strong baselines.

Machine learning algorithms are used in diverse domains, many of which face significant challenges due to data imbalance. Studies have explored various approaches to address the issue, like data preprocessing, cost-sensitive learning, and ensemble methods. Generative Adversarial Networks (GANs) showed immense potential as a data preprocessing technique that generates good quality synthetic data. This study employs a systematic mapping methodology to analyze 3041 papers on GAN-based sampling techniques for imbalanced data sourced from four digital libraries. A filtering process identified 100 key studies spanning domains such as healthcare, finance, and cybersecurity. Through comprehensive quantitative analysis, this research introduces three categorization mappings as application domains, GAN techniques, and GAN variants used to handle the imbalanced nature of the data. GAN-based over-sampling emerges as an effective preprocessing method. Advanced architectures and tailored frameworks helped GANs to improve further in the case of data imbalance. GAN variants like vanilla GAN, CTGAN, and CGAN show great adaptability in structured imbalanced data cases. Interest in GANs for imbalanced data has grown tremendously, touching a peak in recent years, with journals and conferences playing crucial roles in transmitting foundational theories and practical applications. While with these advances, none of the reviewed studies explicitly explore hybridized GAN frameworks with diffusion models or reinforcement learning techniques. This gap leads to a future research idea develop innovative approaches for effectively handling data imbalance.

Unmasking Societal Biases in Respiratory Support for ICU Patients through Social Determinants of Health Mira Moukheiber 1, Lama Moukheiber 1, Dana Moukheiber 1 and Hyung-Chul Lee 2, 1 Massachusetts Institute of Technology 2 Seoul National University College of Medicine, Seoul National University Hospital, Department of Anesthesiology and Pain Medicine vital@snu.ac.kr Abstract In critical care settings, where precise and timely interventions are crucial for health outcomes, evaluating disparities in patient outcomes is important. Current approaches often fall short in comprehensively understanding and evaluating the impact of respiratory support interventions on individuals affected by social determinants of health. Attributes such as gender, race, and age are commonly assessed and essential, but provide only a partial view of the complexities faced by diverse populations. In this study, we focus on two clinically motivated tasks: prolonged mechanical ventilation and successful weaning. We also perform fairness audits on the models' predictions across demographic groups and social determinants of health to better understand the health inequities in respiratory interventions in the intensive care unit. We also release a temporal benchmark dataset, verified by clinical experts, to enable benchmarking of clinical respiratory intervention tasks. 1 Introduction Critically-ill patients often find themselves in the intensive care unit (ICU) seeking specialized support for respiratory distress [ Doyle et al., 1995; Ware and Matthay, 2000 ] . Despite advances in supportive treatments, the in-hospital mortality rate remains 40% for conditions such as acute lung injury and acute respiratory distress syndrome [ Rubenfeld et al., 2005; Sweatt and Levitt, 2014 ] .

Machine learning (ML) has been playing important roles in drug discovery in the past years by providing (pre-)screening tools for prioritising chemical compounds to pass through wet lab experiments. One of the main ML tasks in drug discovery is to build quantitative structure-activity relationship (QSAR) models, associating the molecular structure of chemical compounds with an activity or property. These properties -- including absorption, distribution, metabolism, excretion and toxicity (ADMET) -- are essential to model compound behaviour, activity and interactions in the organism. Although several methods exist, the majority of them do not provide an appropriate model's personalisation, yielding to bias and lack of generalisation to new data since the chemical space usually shifts from application to application. This fact leads to low predictive performance when completely new data is being tested by the model. The area of Automated Machine Learning (AutoML) emerged aiming to solve this issue, outputting tailored ML algorithms to the data at hand. Although an important task, AutoML has not been practically used to assist cheminformatics and computational chemistry researchers often, with just a few works related to the field. To address these challenges, this work introduces Auto-ADMET, an interpretable evolutionary-based AutoML method for chemical ADMET property prediction. Auto-ADMET employs a Grammar-based Genetic Programming (GGP) method with a Bayesian Network Model to achieve comparable or better predictive performance against three alternative methods -- standard GGP method, pkCSM and XGBOOST model -- on 12 benchmark chemical ADMET property prediction datasets. The use of a Bayesian Network model on Auto-ADMET's evolutionary process assisted in both shaping the search procedure and interpreting the causes of its AutoML performance.

It has been 100 years since statistical process control (SPC) or statistical process monitoring (SPM) was first introduced for production processes and later applied to service, healthcare, and other industries. The techniques applied to SPM applications are mostly statistically oriented. Recent advances in Artificial Intelligence (AI) have reinvigorated the imagination of adopting AI for SPM applications. This manuscript begins with a concise review of the historical development of the statistically based SPM methods. Next, this manuscript explores AI and Machine Learning (ML) algorithms and methods applied in various SPM applications, addressing quality characteristics of univariate, multivariate, profile, and image. These AI methods can be classified into the following categories: classification, pattern recognition, time series applications, and generative AI. Specifically, different kinds of neural networks, such as artificial neural networks (ANN), convolutional neural networks (CNN), recurrent neural networks (RNN), and generative adversarial networks (GAN), are among the most implemented AI methods impacting SPM. Finally, this manuscript outlines a couple of future directions that harness the potential of the Large Multimodal Model (LMM) for advancing SPM research and applications in complex systems. The ultimate objective is to transform statistical process monitoring (SPM) into smart process control (SMPC), where corrective actions are autonomously implemented to either prevent quality issues or restore process performance.

Large Language models (LLMs) have achieved encouraging results in tabular data generation. However, existing approaches require fine-tuning, which is computationally expensive. This paper explores an alternative: prompting a fixed LLM with in-context examples. We observe that using randomly selected in-context examples hampers the LLM's performance, resulting in sub-optimal generation quality. To address this, we propose a novel in-context learning framework: TabGen-ICL, to enhance the in-context learning ability of LLMs for tabular data generation. TabGen-ICL operates iteratively, retrieving a subset of real samples that represent the residual between currently generated samples and true data distributions. This approach serves two purposes: locally, it provides more effective in-context learning examples for the LLM in each iteration; globally, it progressively narrows the gap between generated and real data. Extensive experiments on five real-world tabular datasets demonstrate that TabGen-ICL significantly outperforms the random selection strategy. Specifically, it reduces the error rate by a margin of $3.5\%-42.2\%$ on fidelity metrics. We demonstrate for the first time that prompting a fixed LLM can yield high-quality synthetic tabular data. The code is provided in the \href{https://github.com/fangliancheng/TabGEN-ICL}{link}.

Autonomous driving is at a critical stage in revolutionizing transportation systems and reshaping societal norms. More than 1,400 self-driving cars, trucks, and other vehicles are currently in operation or testing in the U.S. (Etherington 2019), and 4.5 million autonomous vehicles are expected to run on U.S. roads by 2030 (Meyer 2023). While autonomous driving is promising in improving traffic efficiency and personal mobility, safety is a prerequisite of all possible achievements and is becoming the first priority in practice (Du et al. 2020). In October 2023, Cruise, one of the leading autonomous driving companies, was ordered by California to stop operations of driverless cars in the state after one of Cruise's cars struck a pedestrian in San Francisco (Kerr 2023). The rare incident involved a woman who was first hit by a human driver and then thrown onto the road in front of a Cruise vehicle. The Cruise vehicle then rolled over the pedestrian and finally stopped on top of her, causing serious injuries. Such an accident reflects one of the greatest challenges in autonomous driving: the safety of an autonomous car is largely determined by the ability to detect and react to rare scenarios rather than common normal situations, which have been well considered during development. Although rare in a long-tailed distribution, unusual driving scenarios do happen and can have large impact on driving safety. To mitigate the impact of abnormal ego behaviors when outside the design domains, a detection system for anomalous driving scenarios is necessary, the output of which can be potentially used as a high-level decision for motion planning.

In this paper we present the symbol and bit error rate performance of the weak signal digital communications system. We investigate orthogonal multiple frequency shift keying modulation scheme with supervised machine learning demodulation approach using simple dense end-to-end artificial neural network. We focus on the interference immunity over an additive white Gaussian noise with average signal-to-noise ratios from -20 dB to 0 dB.