Machine learning has revolutionized numerous domains, playing a crucial role in driving advancements and enabling data-centric processes. The significance of data in training models and shaping their performance cannot be overstated. Recent research has highlighted the heterogeneous impact of individual data samples, particularly the presence of valuable data that significantly contributes to the utility and effectiveness of machine learning models. However, a critical question remains unanswered: are these valuable data samples more vulnerable to machine learning attacks? In this work, we investigate the relationship between data importance and machine learning attacks by analyzing five distinct attack types. Our findings reveal notable insights. For example, we observe that high importance data samples exhibit increased vulnerability in certain attacks, such as membership inference and model stealing. By analyzing the linkage between membership inference vulnerability and data importance, we demonstrate that sample characteristics can be integrated into membership metrics by introducing sample-specific criteria, therefore enhancing the membership inference performance. These findings emphasize the urgent need for innovative defense mechanisms that strike a balance between maximizing utility and safeguarding valuable data against potential exploitation.

Process curves are multi-variate finite time series data coming from manufacturing processes. This paper studies machine learning methods for drifts of process curves. A theoretic framework to synthetically generate process curves in a controlled way is introduced in order to benchmark machine learning algorithms for process drift detection. A evaluation score, called the temporal area under the curve, is introduced, which allows to quantify how well machine learning models unveil curves belonging to drift segments. Finally, a benchmark study comparing popular machine learning approaches on synthetic data generated with the introduced framework shown.

Background: The 2024 Mpox outbreak, particularly severe in Africa with clade 1b emergence, has highlighted critical gaps in diagnostic capabilities in resource-limited settings. This study aimed to develop and validate an artificial intelligence (AI)-driven, on-device screening tool for Mpox, designed to function offline in low-resource environments. Methods: We developed a YOLOv8n-based deep learning model trained on 2,700 images (900 each of Mpox, other skin conditions, and normal skin), including synthetic data. The model was validated on 360 images and tested on 540 images. A larger external validation was conducted using 1,500 independent images. Performance metrics included accuracy, precision, recall, F1-score, sensitivity, and specificity. Findings: The model demonstrated high accuracy (96%) in the final test set. For Mpox detection, it achieved 93% precision, 97% recall, and an F1-score of 95%. Sensitivity and specificity for Mpox detection were 97% and 96%, respectively. Performance remained consistent in the larger external validation, confirming the model's robustness and generalizability. Interpretation: This AI-driven screening tool offers a rapid, accurate, and scalable solution for Mpox detection in resource-constrained settings. Its offline functionality and high performance across diverse datasets suggest significant potential for improving Mpox surveillance and management, particularly in areas lacking traditional diagnostic infrastructure.

Investors are continuously seeking profitable investment opportunities in startups and, hence, for effective decision-making, need to predict a startup's probability of success. Nowadays, investors can use not only various fundamental information about a startup (e.g., the age of the startup, the number of founders, and the business sector) but also textual description of a startup's innovation and business model, which is widely available through online venture capital (VC) platforms such as Crunchbase. To support the decision-making of investors, we develop a machine learning approach with the aim of locating successful startups on VC platforms. Specifically, we develop, train, and evaluate a tailored, fused large language model to predict startup success. Thereby, we assess to what extent self-descriptions on VC platforms are predictive of startup success. Using 20,172 online profiles from Crunchbase, we find that our fused large language model can predict startup success, with textual self-descriptions being responsible for a significant part of the predictive power. Our work provides a decision support tool for investors to find profitable investment opportunities.

Heart disease is a serious worldwide health issue because it claims the lives of many people who might have been treated if the disease had been identified earlier. The leading cause of death in the world is cardiovascular disease, usually referred to as heart disease. Creating reliable, effective, and precise predictions for these diseases is one of the biggest issues facing the medical world today. Although there are tools for predicting heart diseases, they are either expensive or challenging to apply for determining a patient's risk. The best classifier for foretelling and spotting heart disease was the aim of this research. This experiment examined a range of machine learning approaches, including Logistic Regression, K-Nearest Neighbor, Support Vector Machine, and Artificial Neural Networks, to determine which machine learning algorithm was most effective at predicting heart diseases. One of the most often utilized data sets for this purpose, the UCI heart disease repository provided the data set for this study. The K-Nearest Neighbor technique was shown to be the most effective machine learning algorithm for determining whether a patient has heart disease. It will be beneficial to conduct further studies on the application of additional machine learning algorithms for heart disease prediction.

We consider the overfitting behavior of minimum norm interpolating solutions of Gaussian kernel ridge regression (i.e. kernel ridgeless regression), when the bandwidth or input dimension varies with the sample size. For fixed dimensions, we show that even with varying or tuned bandwidth, the ridgeless solution is never consistent and, at least with large enough noise, always worse than the null predictor. For increasing dimension, we give a generic characterization of the overfitting behavior for any scaling of the dimension with sample size. We use this to provide the first example of benign overfitting using the Gaussian kernel with sub-polynomial scaling dimension. All our results are under the Gaussian universality ansatz and the (non-rigorous) risk predictions in terms of the kernel eigenstructure.

This paper presents the Multimodal Analyzing System for Laryngoscope (MASL), a system that combines audio and video data to automatically extract key segments and metrics from laryngeal videostroboscopic videos for clinical assessment. MASL integrates glottis detection with keyword spotting to analyze patient vocalizations and refine video highlights for better inspection of vocal cord movements. The system includes a strobing video extraction module that identifies frames by analyzing hue, saturation, and value fluctuations. MASL also provides effective metrics for vocal cord paralysis detection, employing a two-stage glottis segmentation process using U-Net followed by diffusion-based refinement to reduce false positives. Instead of glottal area waveforms, MASL estimates anterior glottic angle waveforms (AGAW) from glottis masks, evaluating both left and right vocal cords to detect unilateral vocal cord paralysis (UVFP). By comparing AGAW variances, MASL distinguishes between left and right paralysis. Ablation studies and experiments on public and real-world datasets validate MASL's segmentation module and demonstrate its ability to provide reliable metrics for UVFP diagnosis.

Prediction models inform important clinical decisions, aiding in diagnosis, prognosis, and treatment planning. The predictive performance of these models is typically assessed through discrimination and calibration. However, changes in the distribution of the data impact model performance. In health-care, a typical change is a shift in case-mix: for example, for cardiovascular risk management, a general practitioner sees a different mix of patients than a specialist in a tertiary hospital. This work introduces a novel framework that differentiates the effects of case-mix shifts on discrimination and calibration based on the causal direction of the prediction task. When prediction is in the causal direction (often the case for prognosis predictions), calibration remains stable under case-mix shifts, while discrimination does not. Conversely, when predicting in the anti-causal direction (often with diagnosis predictions), discrimination remains stable, but calibration does not. A simulation study and empirical validation using cardiovascular disease prediction models demonstrate the implications of this framework. This framework provides critical insights for evaluating and deploying prediction models across different clinical settings, emphasizing the importance of understanding the causal structure of the prediction task.

Increased usage of automated tools like deep learning in medical image segmentation has alleviated the bottleneck of manual contouring. This has shifted manual labour to quality assessment (QA) of automated contours which involves detecting errors and correcting them. A potential solution to semi-automated QA is to use deep Bayesian uncertainty to recommend potentially erroneous regions, thus reducing time spent on error detection. Previous work has investigated the correspondence between uncertainty and error, however, no work has been done on improving the "utility" of Bayesian uncertainty maps such that it is only present in inaccurate regions and not in the accurate ones. Our work trains the FlipOut model with the Accuracy-vs-Uncertainty (AvU) loss which promotes uncertainty to be present only in inaccurate regions. We apply this method on datasets of two radiotherapy body sites, c.f. head-and-neck CT and prostate MR scans. Uncertainty heatmaps (i.e. predictive entropy) are evaluated against voxel inaccuracies using Receiver Operating Characteristic (ROC) and Precision-Recall (PR) curves. Numerical results show that when compared to the Bayesian baseline the proposed method successfully suppresses uncertainty for accurate voxels, with similar presence of uncertainty for inaccurate voxels. Code to reproduce experiments is available at https://github.com/prerakmody/bayesuncertainty-error-correspondence

Given the societal impact of unsafe content generated by large language models (LLMs), ensuring that LLM services comply with safety standards is a crucial concern for LLM service providers. Common content moderation methods are limited by an effectiveness-and-efficiency dilemma, where simple models are fragile while sophisticated models consume excessive computational resources. In this paper, we reveal for the first time that effective and efficient content moderation can be achieved by extracting conceptual features from chat-oriented LLMs, despite their initial fine-tuning for conversation rather than content moderation. We propose a practical and unified content moderation framework for LLM services, named Legilimens, which features both effectiveness and efficiency. Our red-team model-based data augmentation enhances the robustness of Legilimens against state-of-the-art jailbreaking. Additionally, we develop a framework to theoretically analyze the cost-effectiveness of Legilimens compared to other methods. We have conducted extensive experiments on five host LLMs, seventeen datasets, and nine jailbreaking methods to verify the effectiveness, efficiency, and robustness of Legilimens against normal and adaptive adversaries. A comparison of Legilimens with both commercial and academic baselines demonstrates the superior performance of Legilimens. Furthermore, we confirm that Legilimens can be applied to few-shot scenarios and extended to multi-label classification tasks.