The introduction of 5G and the Open Radio Access Network (O-RAN) architecture has enabled more flexible and intelligent network deployments. However, the increased complexity and openness of these architectures also introduce novel security challenges, such as data manipulation attacks on the semi-standardised Shared Data Layer (SDL) within the O-RAN platform through malicious xApps. In particular, malicious xApps can exploit this vulnerability by introducing subtle Unicode-wise alterations (hypoglyphs) into the data that are being used by traditional machine learning (ML)-based anomaly detection methods. These Unicode-wise manipulations can potentially bypass detection and cause failures in anomaly detection systems based on traditional ML, such as AutoEncoders, which are unable to process hypoglyphed data without crashing. We investigate the use of Large Language Models (LLMs) for anomaly detection within the O-RAN architecture to address this challenge. We demonstrate that LLM-based xApps maintain robust operational performance and are capable of processing manipulated messages without crashing. While initial detection accuracy requires further improvements, our results highlight the robustness of LLMs to adversarial attacks such as hypoglyphs in input data. There is potential to use their adaptability through prompt engineering to further improve the accuracy, although this requires further research. Additionally, we show that LLMs achieve low detection latency (under 0.07 seconds), making them suitable for Near-Real-Time (Near-RT) RIC deployments.

Simulators have revolutionized scientific practice across the natural sciences. By generating data that reliably approximate real-world phenomena, they enable scientists to accelerate hypothesis testing and optimize experimental designs [1, 2]. This is perhaps best illustrated by AlphaFold, a Nobel-prize winning simulator in chemistry that predicts protein structures from amino acid sequences, enabling rapid prototyping of molecular interactions, drug targets, and protein functions [1]. In the behavioral sciences, a reliable participant simulator--a system capable of producing human-like behavior across cognitive tasks--would represent a similarly transformative advance [3]. Recently, Binz et al. introduced Centaur, a large language model (LLM) fine-tuned on human data from 160 experiments, proposing its use not only as a model of cognition but also as a participant simulator for "in silico prototyping of experimental studies" [4], e.g., to advance automated cognitive science [3, 5]. Although Centaur demonstrates strong predictive accuracy, its generative behavior-- a critical criterion for a participant simulator--systematically diverges from human data. This suggests that, while Centaur is a significant step toward predicting human behavior, it does not yet meet the standards of a reliable participant simulator or an accurate model of cognition. A core criterion for any behavioral simulator is its ability to generate behavioral patterns observed in experiments.

Invasive ductal carcinoma (IDC) is the most prevalent form of breast cancer, and early, accurate diagnosis is critical to improving patient survival rates by guiding treatment decisions. Combining medical expertise with artificial intelligence (AI) holds significant promise for enhancing the precision and efficiency of IDC detection. In this work, we propose a human-in-the-loop (HITL) deep learning system designed to detect IDC in histopathology images. The system begins with an initial diagnosis provided by a high-performance EfficientNetV2S model, offering feedback from AI to the human expert. Medical professionals then review the AI-generated results, correct any misclassified images, and integrate the revised labels into the training dataset, forming a feedback loop from the human back to the AI. This iterative process refines the model's performance over time. The EfficientNetV2S model itself achieves state-of-the-art performance compared to existing methods in the literature, with an overall accuracy of 93.65\%. Incorporating the human-in-the-loop system further improves the model's accuracy using four experimental groups with misclassified images. These results demonstrate the potential of this collaborative approach to enhance AI performance in diagnostic systems. This work contributes to advancing automated, efficient, and highly accurate methods for IDC detection through human-AI collaboration, offering a promising direction for future AI-assisted medical diagnostics.

Though intelligent agents are supposed to improve human experience (or make it more efficient), it is hard from a human perspective to grasp the ethical values which are explicitly or implicitly embedded in an agent behaviour. This is the well-known problem of alignment, which refers to the challenge of designing AI systems that align with human values, goals and preferences. This problem is particularly challenging since most human ethical considerations refer to \emph{incommensurable} (i.e. non-measurable and/or incomparable) values and criteria. Consider, for instance, a medical agent prescribing a treatment to a cancerous patient. How could it take into account (and/or weigh) incommensurable aspects like the value of a human life and the cost of the treatment? Now, the alignment between human and artificial values is possible only if we define a common space where a metric can be defined and used. This paper proposes to extend to ethics the conventional Anything2vec approach, which has been successful in plenty of similar and hard-to-quantify domains (ranging from natural language processing to recommendation systems and graph analysis). This paper proposes a way to map an automatic agent decision-making (or control law) strategy to a multivariate vector representation, which can be used to compare and assess the alignment with human values. The Ethics2Vec method is first introduced in the case of an automatic agent performing binary decision-making. Then, a vectorisation of an automatic control law (like in the case of a self-driving car) is discussed to show how the approach can be extended to automatic control settings.

AI has the potential to augment human decision making. However, even high-performing models can produce inaccurate predictions when deployed. These inaccuracies, combined with automation bias, where humans overrely on AI predictions, can result in worse decisions. Selective prediction, in which potentially unreliable model predictions are hidden from users, has been proposed as a solution. This approach assumes that when AI abstains and informs the user so, humans make decisions as they would without AI involvement. To test this assumption, we study the effects of selective prediction on human decisions in a clinical context. We conducted a user study of 259 clinicians tasked with diagnosing and treating hospitalized patients. We compared their baseline performance without any AI involvement to their AI-assisted accuracy with and without selective prediction. Our findings indicate that selective prediction mitigates the negative effects of inaccurate AI in terms of decision accuracy. Compared to no AI assistance, clinician accuracy declined when shown inaccurate AI predictions (66% [95% CI: 56%-75%] vs. 56% [95% CI: 46%-66%]), but recovered under selective prediction (64% [95% CI: 54%-73%]). However, while selective prediction nearly maintains overall accuracy, our results suggest that it alters patterns of mistakes: when informed the AI abstains, clinicians underdiagnose (18% increase in missed diagnoses) and undertreat (35% increase in missed treatments) compared to no AI input at all. Our findings underscore the importance of empirically validating assumptions about how humans engage with AI within human-AI systems.

Proteins are essential macromolecules responsible for the structural and functional mechanisms of living things. Phage structural proteins are a subclass of the protein family corresponding to the bacteriophages, which are the most prevalent kind of biological creatures [1]. The PVPs are mainly associated with building structural constituents of the bacteriophage [2], such as the baseplate and head as shown in Figure 1, enabling efficient host-phage binding for genome transfer. The amino acid sequences, particularly those involved in structure synthesis, exhibit significant diversity among phages and their respective groups [3]. Consequently, characterizing these sequences becomes a challenging yet crucial task, as the shortage of annotations for phage proteins has emerged as a hindrance in numerous research studies focused on phage genomics [4]. With the advent of high-throughput sequencing technology, rapid additions of sequences are being observed in standard biological databases [6] as shown in Figure 1, giving rise to the need for proper annotation of the sequences. Enhancement of annotations for the phage family is vital for exploring effective anti-bacterial drug synthesis [7, 8], disease diagnosis [9], food production [10], bacterial genome remodeling [11], etc. Traditionally, mass spectrometry and protein array techniques [12, 13] were utilized for characterizing these proteins. However, these methods are associated with significant time, labor, and computational expenses [1]. Similarly, alignment-based methods do not always work well with PVP categorization due to the lack of collinearity [14] in viral genomes, resulting from factors such as horizontal gene transfer, high mutation rates, etc., leading to dissimilar sequences 2 Figure 1 Structural constituents of Phage

This study explores the intersection of electroencephalography (EEG) microstates and Large Language Models (LLMs) to enhance the assessment of cognitive load states. By utilizing EEG microstate features, the research aims to fine-tune LLMs for improved predictions of distinct cognitive states, specifically 'Rest' and 'Load'. The experimental design is delineated in four comprehensive stages: dataset collection and preprocessing, microstate segmentation and EEG backfitting, feature extraction paired with prompt engineering, and meticulous LLM model selection and refinement. Employing a supervised learning paradigm, the LLM is trained to identify cognitive load states based on EEG microstate features integrated into prompts, producing accurate discrimination of cognitive load. A curated dataset, linking EEG features to specified cognitive load conditions, underpins the experimental framework. The results indicate a significant improvement in model performance following the proposed fine-tuning, showcasing the potential of EEG-informed LLMs in cognitive neuroscience and cognitive AI applications. This approach not only contributes to the understanding of brain dynamics but also paves the way for advancements in machine learning techniques applicable to cognitive load and cognitive AI research.

Reliable seizure detection is critical for diagnosing and managing epilepsy, yet clinical workflows remain dependent on time-consuming manual EEG interpretation. While machine learning has shown promise, existing approaches often rely on dataset-specific optimisations, limiting their real-world applicability and reproducibility. Here, we introduce an innovative, open-source machine-learning framework that enables robust and generalisable seizure detection across varied clinical datasets. We evaluate our approach on two publicly available EEG datasets that differ in patient populations and electrode configurations. To enhance robustness, the framework incorporates an automated pre-processing pipeline to standardise data and a majority voting mechanism, in which multiple models independently assess each second of EEG before reaching a final decision. We train, tune, and evaluate models within each dataset, assessing their cross-dataset transferability. Our models achieve high within-dataset performance (AUC 0.904+/-0.059 for CHB-MIT and 0.864+/-0.060 for TUSZ) and demonstrate strong generalisation across datasets despite differences in EEG setups and populations (AUC 0.615+/-0.039 for models trained on CHB-MIT and tested on TUSZ and 0.762+/-0.175 in the reverse case) without any post-processing. Furthermore, a mild post-processing improved the within-dataset results to 0.913+/-0.064 and 0.867+/-0.058 and cross-dataset results to 0.619+/-0.036 and 0.768+/-0.172. These results underscore the potential of, and essential considerations for, deploying our framework in diverse clinical settings. By making our methodology fully reproducible, we provide a foundation for advancing clinically viable, dataset-agnostic seizure detection systems. This approach has the potential for widespread adoption, complementing rather than replacing expert interpretation, and accelerating clinical integration.

Heuristic negative sampling enhances recommendation performance by selecting negative samples of varying hardness levels from predefined candidate pools to guide the model toward learning more accurate decision boundaries. However, our empirical and theoretical analyses reveal that unobserved environmental confounders (e.g., exposure or popularity biases) in candidate pools may cause heuristic sampling methods to introduce false hard negatives (FHNS). These misleading samples can encourage the model to learn spurious correlations induced by such confounders, ultimately compromising its generalization ability under distribution shifts. To address this issue, we propose a novel method named Causal Negative Sampling via Diffusion (CNSDiff). By synthesizing negative samples in the latent space via a conditional diffusion process, CNSDiff avoids the bias introduced by predefined candidate pools and thus reduces the likelihood of generating FHNS. Moreover, it incorporates a causal regularization term to explicitly mitigate the influence of environmental confounders during the negative sampling process, leading to robust negatives that promote out-of-distribution (OOD) generalization. Comprehensive experiments under four representative distribution shift scenarios demonstrate that CNSDiff achieves an average improvement of 13.96% across all evaluation metrics compared to state-of-the-art baselines, verifying its effectiveness and robustness in OOD recommendation tasks.

Generative image models have achieved remarkable progress in both natural and medical imaging. In the medical context, these techniques offer a potential solution to data scarcity--especially for low-prevalence anomalies that impair the performance of AI-driven diagnostic and segmentation tools. However, questions remain regarding the fidelity and clinical utility of synthetic images, since poor generation quality can undermine model generalizability and trust. In this study, we evaluate the effectiveness of state-of-the-art generative models--Generative Adversarial Networks (GANs) and Diffusion Models (DMs)--for synthesizing chest X-rays conditioned on four abnormalities: Atelectasis (AT), Lung Opacity (LO), Pleural Effusion (PE), and Enlarged Cardiac Silhouette (ECS). Using a benchmark composed of real images from the MIMIC-CXR dataset and synthetic images from both GANs and DMs, we conducted a reader study with three radiologists of varied experience. Participants were asked to distinguish real from synthetic images and assess the consistency between visual features and the target abnormality. Our results show that while DMs generate more visually realistic images overall, GANs can report better accuracy for specific conditions, such as absence of ECS. We further identify visual cues radiologists use to detect synthetic images, offering insights into the perceptual gaps in current models. These findings underscore the complementary strengths of GANs and DMs and point to the need for further refinement to ensure generative models can reliably augment training datasets for AI diagnostic systems.