Metabolic disorders, particularly type 2 diabetes mellitus (T2DM), represent a significant global health burden, disproportionately impacting genetically predisposed populations such as the Pima Indians (a Native American tribe from south central Arizona). This study introduces a novel machine learning (ML) framework that integrates predictive modeling with gene-agnostic pathway mapping to identify high-risk individuals and uncover potential therapeutic targets. Using the Pima Indian dataset, logistic regression and t-tests were applied to identify key predictors of T2DM, yielding an overall model accuracy of 78.43%. To bridge predictive analytics with biological relevance, we developed a pathway mapping strategy that links identified predictors to critical signaling networks, including insulin signaling, AMPK, and PPAR pathways. This approach provides mechanistic insights without requiring direct molecular data. Building upon these connections, we propose therapeutic strategies such as dual GLP-1/GIP receptor agonists, AMPK activators, SIRT1 modulators, and phytochemical, further validated through pathway enrichment analyses. Overall, this framework advances precision medicine by offering interpretable and scalable solutions for early detection and targeted intervention in metabolic disorders. The key contributions of this work are: (1) development of an ML framework combining logistic regression and principal component analysis (PCA) for T2DM risk prediction; (2) introduction of a gene-agnostic pathway mapping approach to generate mechanistic insights; and (3) identification of novel therapeutic strategies tailored for high-risk populations.

This study explores the application of supervised machine learning algorithms to predict coffee ratings based on a combination of influential textual and numerical attributes extracted from user reviews. Through careful data preprocessing including text cleaning, feature extraction using TF-IDF, and selection with SelectKBest, the study identifies key factors contributing to coffee quality assessments. Six models (Decision Tree, KNearest Neighbors, Multi-layer Perceptron, Random Forest, Extra Trees, and XGBoost) were trained and evaluated using optimized hyperparameters. Model performance was assessed primarily using F1-score, Gmean, and AUC metrics. Results demonstrate that ensemble methods (Extra Trees, Random Forest, and XGBoost), as well as Multi-layer Perceptron, consistently outperform simpler classifiers (Decision Trees and K-Nearest Neighbors) in terms of evaluation metrics such as F1 scores, G-mean and AUC. The findings highlight the essence of rigorous feature selection and hyperparameter tuning in building robust predictive systems for sensory product evaluation, offering a data driven approach to complement traditional coffee cupping by expertise of trained professionals.

Accurate recognition of vessel types from Automatic Identification System (AIS) tracks is essential for safety oversight and combating illegal, unreported, and unregulated (IUU) activity. This paper presents a strait-scale, machine-learning pipeline that classifies moving vessels using only AIS data. We analyze eight days of historical AIS from the Danish Maritime Authority covering the Bornholm Strait in the Baltic Sea (January 22-30, 2025). After forward/backward filling voyage records, removing kinematic and geospatial outliers, and segmenting per-MMSI tracks while excluding stationary periods ($\ge 1$ h), we derive 31 trajectory-level features spanning kinematics (e.g., SOG statistics), temporal, geospatial (Haversine distances, spans), and ship-shape attributes computed from AIS A/B/C/D reference points (length, width, aspect ratio, bridge-position ratio). To avoid leakage, we perform grouped train/test splits by MMSI and use stratified 5-fold cross-validation. Across five classes (cargo, tanker, passenger, high-speed craft, fishing; N=1{,}910 trajectories; test=382), tree-based models dominate: a Random Forest with SMOTE attains 92.15% accuracy (macro-precision 94.11%, macro-recall 92.51%, macro-F1 93.27%) on the held-out test set, while a tuned RF reaches one-vs-rest ROC-AUC up to 0.9897. Feature-importance analysis highlights the bridge-position ratio and maximum SOG as the most discriminative signals; principal errors occur between cargo and tanker, reflecting similar transit behavior. We demonstrate operational value by backfilling missing ship types on unseen data and discuss improvements such as DBSCAN based trip segmentation and gradient-boosted ensembles to handle frequent-stop ferries and further lift performance. The results show that lightweight features over AIS trajectories enable real-time vessel type classification in straits.

Tabular Generative Models are often argued to preserve privacy by creating synthetic datasets that resemble training data. However, auditing their empirical privacy remains challenging, as commonly used similarity metrics fail to effectively characterize privacy risk. Membership Inference Attacks (MIAs) have recently emerged as a method for evaluating privacy leakage in synthetic data, but their practical effectiveness is limited. Numerous attacks exist across different threat models, each with distinct implementations targeting various sources of privacy leakage, making them difficult to apply consistently. Moreover, no single attack consistently outperforms the others, leading to a routine underestimation of privacy risk. To address these issues, we propose a unified, model-agnostic threat framework that deploys a collection of attacks to estimate the maximum empirical privacy leakage in synthetic datasets. We introduce Synth-MIA, an open-source Python library that streamlines this auditing process through a novel testbed that integrates seamlessly into existing synthetic data evaluation pipelines through a Scikit-Learn-like API. Our software implements 13 attack methods through a Scikit-Learn-like API, designed to enable fast systematic estimation of privacy leakage for practitioners as well as facilitate the development of new attacks and experiments for researchers. We demonstrate our framework's utility in the largest tabular synthesis privacy benchmark to date, revealing that higher synthetic data quality corresponds to greater privacy leakage, that similarity-based privacy metrics show weak correlation with MIA results, and that the differentially private generator PATEGAN can fail to preserve privacy under such attacks. This underscores the necessity of MIA-based auditing when designing and deploying Tabular Generative Models.

This paper introduces a novel framework for estimation theory by introducing a second-order diagnostic for estimator design. While classical analysis focuses on the bias-variance trade-off, we present a more foundational constraint. This result is model-agnostic, domain-agnostic, and is valid for both parametric and non-parametric problems, Bayesian and frequentist frameworks. We propose to classify the estimators into three primary power regimes. We theoretically establish that any estimator operating in the `power-dominant regime' incurs an unavoidable mean-squared error penalty, making it structurally prone to sub-optimal performance. We propose a `safe-zone law' and make this diagnostic intuitive through two safe-zone maps. One map is a geometric visualization analogous to a receiver operating characteristic curve for estimators, and the other map shows that the safe-zone corresponds to a bounded optimization problem, while the forbidden `power-dominant zone' represents an unbounded optimization landscape. This framework reframes estimator design as a path optimization problem, providing new theoretical underpinnings for regularization and inspiring novel design philosophies.

Recent advances have shown that scaling test-time computation enables large language models (LLMs) to solve increasingly complex problems across diverse domains. One effective paradigm for test-time scaling (TTS) involves LLM generators producing multiple solution candidates, with LLM verifiers assessing the correctness of these candidates without reference answers. In this paper, we study generative verifiers, which perform verification by generating chain-of-thought (CoT) reasoning followed by a binary verdict. We systematically analyze verification dynamics across three dimensions - problem difficulty, generator capability, and verifier generation capability - with empirical studies on 12 benchmarks across mathematical reasoning, knowledge, and natural language reasoning tasks using 14 open-source models (2B to 72B parameter range) and GPT-4o. Our experiments reveal three key findings about verification effectiveness: (1) Easy problems allow verifiers to more reliably certify correct responses; (2) Weak generators produce errors that are easier to detect than strong generators; (3) Verification ability is generally correlated with the verifier's own problem-solving capability, but this relationship varies with problem difficulty. These findings reveal opportunities to optimize basic verification strategies in TTS applications. First, given the same verifier, some weak generators can nearly match stronger ones in post-verification TTS performance (e.g., the Gemma2-9B to Gemma2-27B performance gap shrinks by 75.5%). Second, we identify cases where strong verifiers offer limited advantage over weak ones, as both fail to provide meaningful verification gains, suggesting that verifier scaling alone cannot overcome fundamental verification challenges.

In this study, we develop a new CAD system for accurate thyroid cancer classification with emphasis on feature extraction. Prior studies have shown that thyroid texture is important for segregating the thyroid ultrasound images into different classes. Based upon our experience with breast cancer classification, we first conjuncture that the Discrete Cosine Transform (DCT) is the best descriptor for capturing textural features. Thyroid ultrasound images are particularly challenging as the gland is surrounded by multiple complex anatomical structures leading to variations in tissue density. Hence, we second conjuncture the importance of localization and propose that the Local DCT (LDCT) descriptor captures the textural features best in this context. Another disadvantage of complex anatomy around the thyroid gland is scattering of ultrasound waves resulting in noisy and unclear textures. Hence, we third conjuncture that one image descriptor is not enough to fully capture the textural features and propose the integration of another popular texture capturing descriptor (Improved Local Binary Pattern, ILBP) with LDCT. ILBP is known to be noise resilient as well. We term our novel descriptor as Binary Pattern Driven Local Discrete Cosine Transform (BPD-LDCT). Final classification is carried out using a non-linear SVM. The proposed CAD system is evaluated on the only two publicly available thyroid cancer datasets, namely TDID and AUITD. The evaluation is conducted in two stages. In Stage I, thyroid nodules are categorized as benign or malignant. In Stage II, the malignant cases are further sub-classified into TI-RADS (4) and TI-RADS (5). For Stage I classification, our proposed model demonstrates exceptional performance of nearly 100% on TDID and 97% on AUITD. In Stage II classification, the proposed model again attains excellent classification of close to 100% on TDID and 99% on AUITD.

Modern software development pipelines face growing challenges in securing large codebases with extensive dependencies. Static analysis tools like Bandit are effective at vulnerability detection but suffer from high false positives and lack repair capabilities. Large Language Models (LLMs), in contrast, can suggest fixes but often hallucinate changes and lack self-validation. We present SecureFixAgent, a hybrid repair framework integrating Bandit with lightweight local LLMs (<8B parameters) in an iterative detect-repair-validate loop. To improve precision, we apply parameter-efficient LoRA-based fine-tuning on a diverse, curated dataset spanning multiple Python project domains, mitigating dataset bias and reducing unnecessary edits. SecureFixAgent uses Bandit for detection, the LLM for candidate fixes with explanations, and Bandit re-validation for verification, all executed locally to preserve privacy and reduce cloud reliance. Experiments show SecureFixAgent reduces false positives by 10.8% over static analysis, improves fix accuracy by 13.51%, and lowers false positives by 5.46% compared to pre-trained LLMs, typically converging within three iterations. Beyond metrics, developer studies rate explanation quality 4.5/5, highlighting its value for human trust and adoption. By combining verifiable security improvements with transparent rationale in a resource-efficient local framework, SecureFixAgent advances trustworthy, automated vulnerability remediation for modern pipelines.

Abstract--Lung cancer continues to be the predominant cause of cancer-related mortality globally. This review analyzes various approaches, including advanced image processing methods, focusing on their efficacy in interpreting CT scans, chest radiographs, and biological markers. Notably, we identify critical gaps in the previous surveys, including the need for robust models that can generalize across diverse populations and imaging modalities. This comprehensive synthesis aims to serve as a foundational resource for researchers and clinicians, guiding future efforts toward more accurate and efficient lung cancer detection. Key findings reveal that 3D CNN architectures integrated with CT scans achieve the most superior performances, yet challenges such as high false positives, dataset variability, and computational complexity persist across modalities.

State - of - the - art (SOTA) Convolutional Neural Networks (CNNs) are criticized for their extensive computational power, long training times, and large datasets . To overcome this limitation, we propose a reasonable network (R - Net), a lightweight CNN only to detect and classify colorectal cancer (CRC) using the Enteroscope Biopsy Histopathological Hematoxylin and Eosin Image Dataset (EBHI) . Furthermore, six SOTA CNNs, including Multipath - based CNNs (DenseNet121, ResNet50), Depth - based CNNs (InceptionV3), width - based multi - connection CNNs (Xception), depth - wise separable convolutions (MobileNetV2), spatial exploitation - based CNNs (VGG16), Transfer learning, and two ensemble models are also tested on the same dataset . The ensemble models are a multipath - depth - width combination (DenseNet121 - InceptionV3 - Xception) and a multipath - depth - spatial combination ( ResNet18 - InceptionV3 - VGG16) . However, the proposed R - Net lightweight achieved 99.37% accuracy, outperforming MobileNet ( 95.83%) and ResNet50 ( 96.94%). Most importantly, to understand the decision - making of R - Net, Explainable AI such as SHAP, LIME, and Grad - CAM are integrated to visualize which parts of the EBHI image contribute to the detection and classification process of R - Net . The main novelty of this research lies in building a reliable, lightweight CNN R - Net that requires fewer computing resources yet maintains strong prediction results. SOTA CNN s, transfer learning, and ensemble models also extend our knowledge on CRC classification and detection. XAI functionality and the impact of pixel intensity on correct and incorrect classification images are also some novelties in CRC detection and classification.