Solving stochastic optimal control problems with quadratic control costs can be viewed as approximating a target path space measure, e.g. via gradient-based optimization. In practice, however, this optimization is challenging in particular if the target measure differs substantially from the prior. In this work, we therefore approach the problem by iteratively solving constrained problems incorporating trust regions that aim for approaching the target measure gradually in a systematic way. It turns out that this trust region based strategy can be understood as a geometric annealing from the prior to the target measure, where, however, the incorporated trust regions lead to a principled and educated way of choosing the time steps in the annealing path. We demonstrate in multiple optimal control applications that our novel method can improve performance significantly, including tasks in diffusion-based sampling, transition path sampling, and fine-tuning of diffusion models.

Diabetic Retinopathy (DR) is a leading cause of vision loss in working-age individuals. Early detection of DR can reduce the risk of vision loss by up to 95%, but a shortage of retinologists and challenges in timely examination complicate detection. Artificial Intelligence (AI) models using retinal fundus photographs (RFPs) offer a promising solution. However, adoption in clinical settings is hindered by low-quality data and biases that may lead AI systems to learn unintended features. To address these challenges, we developed RAIS-DR, a Responsible AI System for DR screening that incorporates ethical principles across the AI lifecycle. RAIS-DR integrates efficient convolutional models for preprocessing, quality assessment, and three specialized DR classification models. We evaluated RAIS-DR against the FDA-approved EyeArt system on a local dataset of 1,046 patients, unseen by both systems. RAIS-DR demonstrated significant improvements, with F1 scores increasing by 5-12%, accuracy by 6-19%, and specificity by 10-20%. Additionally, fairness metrics such as Disparate Impact and Equal Opportunity Difference indicated equitable performance across demographic subgroups, underscoring RAIS-DR's potential to reduce healthcare disparities. These results highlight RAIS-DR as a robust and ethically aligned solution for DR screening in clinical settings. The code, weights of RAIS-DR are available at https://gitlab.com/inteligencia-gubernamental-jalisco/jalisco-retinopathy with RAIL.

Molecular dynamics simulations (MDS) face challenges, including resource-heavy computations and the need to manually scan outputs to detect "interesting events," such as the formation and persistence of hydrogen bonds between atoms of different molecules. A critical research gap lies in identifying the underlying causes of hydrogen bond formation and separation -understanding which interactions or prior events contribute to their emergence over time. With this challenge in mind, we propose leveraging spatio-temporal data analytics and machine learning models to enhance the detection of these phenomena. In this paper, our approach is inspired by causal modeling and aims to identify the root cause variables of hydrogen bond formation and separation events. Specifically, we treat the separation of hydrogen bonds as an "intervention" occurring and represent the causal structure of the bonding and separation events in the MDS as graphical causal models. These causal models are built using a variational autoencoder-inspired architecture that enables us to infer causal relationships across samples with diverse underlying causal graphs while leveraging shared dynamic information. We further include a step to infer the root causes of changes in the joint distribution of the causal models. By constructing causal models that capture shifts in the conditional distributions of molecular interactions during bond formation or separation, this framework provides a novel perspective on root cause analysis in molecular dynamic systems. We validate the efficacy of our model empirically on the atomic trajectories that used MDS for chiral separation, demonstrating that we can predict many steps in the future and also find the variables driving the observed changes in the system.

Developing collaborative AI hinges on Theory of Mind (ToM) - the ability to reason about the beliefs of others to build and maintain common ground. Existing ToM benchmarks, however, are restricted to passive observer settings or lack an assessment of how agents establish and maintain common ground over time. To address these gaps, we introduce the Yokai Learning Environment (YLE) - a multi-agent reinforcement learning (RL) environment based on the cooperative card game Yokai. In the YLE, agents take turns peeking at hidden cards and moving them to form clusters based on colour. Success requires tracking evolving beliefs, remembering past observations, using hints as grounded communication, and maintaining common ground with teammates. Our evaluation yields two key findings: First, current RL agents struggle to solve the YLE, even when given access to perfect memory. Second, while belief modelling improves performance, agents are still unable to effectively generalise to unseen partners or form accurate beliefs over longer games, exposing a reliance on brittle conventions rather than robust belief tracking. We use the YLE to investigate research questions in belief modelling, memory, partner generalisation, and scaling to higher-order ToM.

Accurate assessment of neuromuscular reflexes, such as the H-reflex, plays a critical role in sports science, rehabilitation, and clinical neurology. Traditional analysis of H-reflex EMG waveforms is subject to variability and interpretation bias among clinicians and researchers, limiting reliability and standardization. To address these challenges, we propose a Fine-Tuned Vision-Language Model (VLM) Consortium and a reasoning Large-Language Model (LLM)-enabled Decision Support System for automated H-reflex waveform interpretation and diagnosis. Our approach leverages multiple VLMs, each fine-tuned on curated datasets of H-reflex EMG waveform images annotated with clinical observations, recovery timelines, and athlete metadata. These models are capable of extracting key electrophysiological features and predicting neuromuscular states, including fatigue, injury, and recovery, directly from EMG images and contextual metadata. Diagnostic outputs from the VLM consortium are aggregated using a consensus-based method and refined by a specialized reasoning LLM, which ensures robust, transparent, and explainable decision support for clinicians and sports scientists. The end-to-end platform orchestrates seamless communication between the VLM ensemble and the reasoning LLM, integrating prompt engineering strategies and automated reasoning workflows using LLM Agents. Experimental results demonstrate that this hybrid system delivers highly accurate, consistent, and interpretable H-reflex assessments, significantly advancing the automation and standardization of neuromuscular diagnostics. To our knowledge, this work represents the first integration of a fine-tuned VLM consortium with a reasoning LLM for image-based H-reflex analysis, laying the foundation for next-generation AI-assisted neuromuscular assessment and athlete monitoring platforms.

Root cause analysis (RCA) in microservice systems is challenging, requiring on-call engineers to rapidly diagnose failures across heterogeneous telemetry such as metrics, logs, and traces. Traditional RCA methods often focus on single modalities or merely rank suspect services, falling short of providing actionable diagnostic insights with remediation guidance. This paper introduces GALA, a novel multi-modal framework that combines statistical causal inference with LLM-driven iterative reasoning for enhanced RCA. Evaluated on an open-source benchmark, GALA achieves substantial improvements over state-of-the-art methods of up to 42.22% accuracy. Our novel human-guided LLM evaluation score shows GALA generates significantly more causally sound and actionable diagnostic outputs than existing methods. Through comprehensive experiments and a case study, we show that GALA bridges the gap between automated failure diagnosis and practical incident resolution by providing both accurate root cause identification and human-interpretable remediation guidance.

The increased Internet of Medical Things IoMT and the Industrial Internet of Things IIoT interconnectivity has introduced complex cybersecurity challenges, exposing sensitive data, patient safety, and industrial operations to advanced cyber threats. To mitigate these risks, this paper introduces a novel transformer-based intrusion detection system IDS, termed BiGAT-ID a hybrid model that combines bidirectional gated recurrent units BiGRU, long short-term memory LSTM networks, and multi-head attention MHA. The proposed architecture is designed to effectively capture bidirectional temporal dependencies, model sequential patterns, and enhance contextual feature representation. Extensive experiments on two benchmark datasets, CICIoMT2024 medical IoT and EdgeIIoTset industrial IoT demonstrate the model's cross-domain robustness, achieving detection accuracies of 99.13 percent and 99.34 percent, respectively. Additionally, the model exhibits exceptional runtime efficiency, with inference times as low as 0.0002 seconds per instance in IoMT and 0.0001 seconds in IIoT scenarios. Coupled with a low false positive rate, BiGAT-ID proves to be a reliable and efficient IDS for deployment in real-world heterogeneous IoT environments

Traditional multimodal learning approaches require expensive alignment pre-training to bridge vision and language modalities, typically projecting visual features into discrete text token spaces. We challenge both fundamental assumptions underlying this paradigm by proposing Inverse-LLaVA, a novel approach that eliminates alignment pre-training entirely while inverting the conventional mapping direction. Rather than projecting visual features to text space, our method maps text embeddings into continuous visual representation space and performs fusion within transformer intermediate layers. Through selective additive components in attention mechanisms, we enable dynamic integration of visual and textual representations without requiring massive image-text alignment datasets. Comprehensive experiments across nine multimodal benchmarks demonstrate nuanced performance trade-offs: Inverse-LLaVA achieves notable improvements on reasoning-intensive and cognitive tasks (MM-VET: +0.2%, VizWiz: +1.8%, ScienceQA: +0.2%, cognitive reasoning: +27.2%), while showing expected decreases in perception tasks requiring memorized visual-text associations (celebrity recognition: -49.5%, OCR: -21.3%). These results provide the first empirical evidence that alignment pre-training is not necessary for effective multimodal learning, particularly for complex reasoning tasks. Our work establishes the feasibility of a new paradigm that reduces computational requirements by 45%, challenges conventional wisdom about modality fusion, and opens new research directions for efficient multimodal architectures that preserve modality-specific characteristics. Our project website with code and additional resources is available at https://inverse-llava.github.io.

Large Vision-Language Models (LVLMs) hold immense potential for complex multimodal instruction following, yet their development is often hindered by the high cost and inconsistency of human annotation required for effective fine-tuning and preference alignment. Traditional supervised fine-tuning (SFT) and existing preference optimization methods like RLHF and DPO frequently struggle to efficiently leverage the model's own generation space to identify highly informative "hard negative" samples. To address these challenges, we propose Multimodal-Model-Guided Preference Optimization (M3PO), a novel and data-efficient method designed to enhance LVLMs' capabilities in visual instruction following. M3PO intelligently selects the most "learning-valuable" preference sample pairs from a diverse pool of LVLM-generated candidates. This selection is driven by a sophisticated mechanism that integrates two crucial signals: a Multimodal Alignment Score (MAS) to assess external quality and the model's Self-Consistency / Confidence (log-probability) to gauge internal belief. These are combined into a novel M3P-Score, which specifically identifies preferred responses and challenging dispreferred responses that the model might confidently generate despite being incorrect. These high-quality preference pairs are then used for efficient Direct Preference Optimization (DPO) fine-tuning on base LVLMs like LLaVA-1.5 (7B/13B) using LoRA. Our extensive experiments demonstrate that M3PO consistently outperforms strong baselines, including SFT, simulated RLHF, vanilla DPO, and RM-DPO, across a comprehensive suite of multimodal instruction following benchmarks (MME-Bench, POPE, IFT, Human Pref. Score).

We present an integrated machine learning framework that transforms how manufacturing cost is estimated from 2D engineering drawings. Unlike traditional quotation workflows that require labor-intensive process planning, our approach about 200 geometric and statistical descriptors directly from 13,684 DWG drawings of automotive suspension and steering parts spanning 24 product groups. Gradient-boosted decision tree models (XGBoost, CatBoost, LightGBM) trained on these features achieve nearly 10% mean absolute percentage error across groups, demonstrating robust scalability beyond part-specific heuristics. By coupling cost prediction with explainability tools such as SHAP, the framework identifies geometric design drivers including rotated dimension maxima, arc statistics and divergence metrics, offering actionable insights for cost-aware design. This end-to-end CAD-to-cost pipeline shortens quotation lead times, ensures consistent and transparent cost assessments across part families and provides a deployable pathway toward real-time, ERP-integrated decision support in Industry 4.0 manufacturing environments.