DPO (Direct Preference Optimization) has become a widely used offline preference optimization algorithm due to its simplicity and training stability. However, DPO is prone to overfitting and collapse. To address these challenges, we propose Linear Preference Optimization (LPO), a novel alignment framework featuring three key innovations. First, we introduce gradient decoupling by replacing the log-sigmoid function with an absolute difference loss, thereby isolating the optimization dynamics. Second, we improve stability through an offset constraint combined with a positive regularization term to preserve the chosen response quality. Third, we implement controllable rejection suppression using gradient separation with straightforward estimation and a tunable coefficient that linearly regulates the descent of the rejection probability. Through extensive experiments, we demonstrate that LPO consistently improves performance on various tasks, including general text tasks, math tasks, and text-to-speech (TTS) tasks. These results establish LPO as a robust and tunable paradigm for preference alignment, and we release the source code, models, and training data publicly.

Tokenization remains a fundamental yet underexplored bottleneck in natural language processing, with strategies largely static despite remarkable progress in model architectures. We present SupraTok, a novel tokenization architecture that reimagines subword segmentation through three innovations: cross-boundary pattern learning that discovers multi-word semantic units, entropy-driven data curation that optimizes training corpus quality, and multi-phase curriculum learning for stable convergence. Our approach extends Byte-Pair Encoding by learning "superword" tokens, coherent multi-word expressions that preserve semantic unity while maximizing compression efficiency. SupraTok achieves 31% improvement in English tokenization efficiency (5.91 versus 4.51 characters per token) compared to OpenAI's o200k tokenizer and 30% improvement over Google's Gemma 3 tokenizer (256k vocabulary), while maintaining competitive performance across 38 languages. When integrated with a GPT-2 scale model (124M parameters) trained on 10 billion tokens from the FineWeb-Edu dataset, SupraTok yields 8.4% improvement on HellaSWAG and 9.5% on MMLU benchmarks without architectural modifications. While these results are promising at this scale, further validation at larger model scales is needed. These findings suggest that efficient tokenization can complement architectural innovations as a path to improved language model performance.

Algorithmic discovery has traditionally relied on human ingenuity and extensive experimentation. Here we investigate whether a prominent scientific computing algorithm, the Kalman Filter, can be discovered through an automated, data-driven, evolutionary process that relies on Cartesian Genetic Programming (CGP) and Large Language Models (LLM). We evaluate the contributions of both modalities (CGP and LLM) in discovering the Kalman filter under varying conditions. Our results demonstrate that our framework of CGP and LLM-assisted evolution converges to near-optimal solutions when Kalman optimality assumptions hold. When these assumptions are violated, our framework evolves interpretable alternatives that outperform the Kalman filter. These results demonstrate that combining evolutionary algorithms and generative models for interpretable, data-driven synthesis of simple computational modules is a potent approach for algorithmic discovery in scientific computing.

Evaluating large language models (LLMs) in specific domain like tourism remains challenging due to the prohibitive cost of annotated benchmarks and persistent issues like hallucinations. We propose $\textbf{L}$able-Free $\textbf{E}$valuation of LLM on $\textbf{T}$ourism using Expert $\textbf{T}$ree-$\textbf{o}$f-$\textbf{T}$hought (LETToT), a framework that leverages expert-derived reasoning structures-instead of labeled data-to access LLMs in tourism. First, we iteratively refine and validate hierarchical ToT components through alignment with generic quality dimensions and expert feedback. Results demonstrate the effectiveness of our systematically optimized expert ToT with 4.99-14.15\% relative quality gains over baselines. Second, we apply LETToT's optimized expert ToT to evaluate models of varying scales (32B-671B parameters), revealing: (1) Scaling laws persist in specialized domains (DeepSeek-V3 leads), yet reasoning-enhanced smaller models (e.g., DeepSeek-R1-Distill-Llama-70B) close this gap; (2) For sub-72B models, explicit reasoning architectures outperform counterparts in accuracy and conciseness ($p<0.05$). Our work established a scalable, label-free paradigm for domain-specific LLM evaluation, offering a robust alternative to conventional annotated benchmarks.

Multi-sequence Magnetic Resonance Imaging (MRI) offers remarkable versatility, enabling the distinct visualization of different tissue types. Nevertheless, the inherent heterogeneity among MRI sequences poses significant challenges to the generalization capability of deep learning models. These challenges undermine model performance when faced with varying acquisition parameters, thereby severely restricting their clinical utility. In this study, we present PRISM, a foundation model PRe-trained with large-scale multI-Sequence MRI. We collected a total of 64 datasets from both public and private sources, encompassing a wide range of whole-body anatomical structures, with scans spanning diverse MRI sequences. Among them, 336,476 volumetric MRI scans from 34 datasets (8 public and 26 private) were curated to construct the largest multi-organ multi-sequence MRI pretraining corpus to date. We propose a novel pretraining paradigm that disentangles anatomically invariant features from sequence-specific variations in MRI, while preserving high-level semantic representations. We established a benchmark comprising 44 downstream tasks, including disease diagnosis, image segmentation, registration, progression prediction, and report generation. These tasks were evaluated on 32 public datasets and 5 private cohorts. PRISM consistently outperformed both non-pretrained models and existing foundation models, achieving first-rank results in 39 out of 44 downstream benchmarks with statistical significance improvements. These results underscore its ability to learn robust and generalizable representations across unseen data acquired under diverse MRI protocols. PRISM provides a scalable framework for multi-sequence MRI analysis, thereby enhancing the translational potential of AI in radiology. It delivers consistent performance across diverse imaging protocols, reinforcing its clinical applicability.

Large-scale models (LSMs) can be an effective framework for semantic representation and understanding, thereby providing a suitable tool for designing semantic communication (SC) systems. However, their direct deployment is often hindered by high computational complexity and resource requirements. In this paper, a novel robust knowledge distillation based semantic communication (RKD-SC) framework is proposed to enable efficient and \textcolor{black}{channel-noise-robust} LSM-powered SC. The framework addresses two key challenges: determining optimal compact model architectures and effectively transferring knowledge while maintaining robustness against channel noise. First, a knowledge distillation-based lightweight differentiable architecture search (KDL-DARTS) algorithm is proposed. This algorithm integrates knowledge distillation loss and a complexity penalty into the neural architecture search process to identify high-performance, lightweight semantic encoder architectures. Second, a novel two-stage robust knowledge distillation (RKD) algorithm is developed to transfer semantic capabilities from an LSM (teacher) to a compact encoder (student) and subsequently enhance system robustness. To further improve resilience to channel impairments, a channel-aware transformer (CAT) block is introduced as the channel codec, trained under diverse channel conditions with variable-length outputs. Extensive simulations on image classification tasks demonstrate that the RKD-SC framework significantly reduces model parameters while preserving a high degree of the teacher model's performance and exhibiting superior robustness compared to existing methods.

Judgmental forecasting employs human opinions to make predictions about future events, rather than exclusively historical data as in quantitative forecasting. When these opinions form an argumentative structure around forecasts, it is useful to study the properties of the forecasts from an argumentative perspective. In this paper, we advocate and formally define a property of argumentative coherence, which, in essence, requires that a forecaster's reasoning is coherent with their forecast. We then conduct three evaluations with our notion of coherence. First, we assess the impact of enforcing coherence on human forecasters as well as on Large Language Model (LLM)-based forecasters, given that they have recently shown to be competitive with human forecasters. In both cases, we show that filtering out incoherent predictions improves forecasting accuracy consistently, supporting the practical value of coherence in both human and LLM-based forecasting. Then, via crowd-sourced user experiments, we show that, despite its apparent intuitiveness and usefulness, users do not generally align with this coherence property. This points to the need to integrate, within argumentation-based judgmental forecasting, mechanisms to filter out incoherent opinions before obtaining group forecasting predictions.

Rationale and Objectives: To develop and validate PARROT (Polyglottal Annotated Radiology Reports for Open Testing), a large, multicentric, open-access dataset of fictional radiology reports spanning multiple languages for testing natural language processing applications in radiology. Materials and Methods: From May to September 2024, radiologists were invited to contribute fictional radiology reports following their standard reporting practices. Contributors provided at least 20 reports with associated metadata including anatomical region, imaging modality, clinical context, and for non-English reports, English translations. All reports were assigned ICD-10 codes. A human vs. AI report differentiation study was conducted with 154 participants (radiologists, healthcare professionals, and non-healthcare professionals) assessing whether reports were human-authored or AI-generated. Results: The dataset comprises 2,658 radiology reports from 76 authors across 21 countries and 13 languages. Reports cover multiple imaging modalities (CT: 36.1%, MRI: 22.8%, radiography: 19.0%, ultrasound: 16.8%) and anatomical regions, with chest (19.9%), abdomen (18.6%), head (17.3%), and pelvis (14.1%) being most prevalent. In the differentiation study, participants achieved 53.9% accuracy (95% CI: 50.7%-57.1%) in distinguishing between human and AI-generated reports, with radiologists performing significantly better (56.9%, 95% CI: 53.3%-60.6%, p<0.05) than other groups. Conclusion: PARROT represents the largest open multilingual radiology report dataset, enabling development and validation of natural language processing applications across linguistic, geographic, and clinical boundaries without privacy constraints.

The increasing volume of medical images poses challenges for radiologists in retrieving relevant cases. Content-based image retrieval (CBIR) systems offer potential for efficient access to similar cases, yet lack standardized evaluation and comprehensive studies. Building on prior studies for tumor characterization via CBIR, this study advances CBIR research for volumetric medical images through three key contributions: (1) a framework eliminating reliance on pre-segmented data and organ-specific datasets, aligning with large and unstructured image archiving systems, i.e. PACS in clinical practice; (2) introduction of C-MIR, a novel volumetric re-ranking method adapting ColBERT's contextualized late interaction mechanism for 3D medical imaging; (3) comprehensive evaluation across four tumor sites using three feature extractors and three database configurations. Our evaluations highlight the significant advantages of C-MIR. We demonstrate the successful adaptation of the late interaction principle to volumetric medical images, enabling effective context-aware re-ranking. A key finding is C-MIR's ability to effectively localize the region of interest, eliminating the need for pre-segmentation of datasets and offering a computationally efficient alternative to systems relying on expensive data enrichment steps. C-MIR demonstrates promising improvements in tumor flagging, achieving improved performance, particularly for colon and lung tumors (p<0.05). C-MIR also shows potential for improving tumor staging, warranting further exploration of its capabilities. Ultimately, our work seeks to bridge the gap between advanced retrieval techniques and their practical applications in healthcare, paving the way for improved diagnostic processes.

Learning from multi-variate time-series with heterogeneous channel configurations remains a fundamental challenge for deep neural networks, particularly in clinical domains such as intracranial electroencephalography (iEEG), where channel setups vary widely across subjects. In this work, we introduce multi-variate parallel attention (MVPA), a novel self-attention mechanism that disentangles content, temporal, and spatial attention, enabling flexible, generalizable, and efficient modeling of time-series data with varying channel counts and configurations. We use MVPA to build MVPFormer, a generative foundation model for human electrophysiology, trained to predict the evolution of iEEG signals across diverse subjects. To support this and future efforts by the community, we release the SWEC iEEG dataset, the largest publicly available iEEG dataset to date, comprising nearly 10,000 hours of recordings from heterogeneous clinical sources. MVPFormer leverages MVPA to achieve strong generalization across subjects, demonstrating expert-level performance in several iEEG tasks. MVPFormer surpasses state-of-the-art Transformer baselines in seizure detection across the SWEC, the MAYO, and the FNUSA datasets, while also achieving state-of-the-art performance on four Brain TreeBank iEEG decoding tasks. We further validate MVPA on standard time-series forecasting and classification tasks, where it matches or exceeds the performance of existing attention-based models. Together, our contributions establish MVPA as a general-purpose attention mechanism for heterogeneous time-series and MVPFormer as the first open-source, open-weights, and open-data iEEG foundation model with SOTA clinical performance. The code is available at https://github.com/IBM/multi-variate-parallel-transformer. The SWEC iEEG dataset is available at https://huggingface.co/datasets/NeuroTec/SWEC_iEEG_Dataset.