Generative Artificial Intelligence (GenAI) is taking the world by storm. It promises transformative opportunities for advancing and disrupting existing practices, including healthcare. From large language models (LLMs) for clinical note synthesis and conversational assistance to multimodal systems that integrate medical imaging, electronic health records, and genomic data for decision support, GenAI is transforming the practice of medicine and the delivery of healthcare, such as diagnosis and personalized treatments, with great potential in reducing the cognitive burden on clinicians, thereby improving overall healthcare delivery. However, GenAI deployment in healthcare requires an in-depth understanding of healthcare tasks and what can and cannot be achieved. In this paper, we propose a data-centric paradigm in the design and deployment of GenAI systems for healthcare. Specifically, we reposition the data life cycle by making the medical data ecosystem as the foundational substrate for generative healthcare systems. This ecosystem is designed to sustainably support the integration, representation, and retrieval of diverse medical data and knowledge. With effective and efficient data processing pipelines, such as semantic vector search and contextual querying, it enables GenAI-powered operations for upstream model components and downstream clinical applications. Ultimately, it not only supplies foundation models with high-quality, multimodal data for large-scale pretraining and domain-specific fine-tuning, but also serves as a knowledge retrieval backend to support task-specific inference via the agentic layer. The ecosystem enables the deployment of GenAI for high-quality and effective healthcare delivery.

The capability of in-context learning (ICL) enables large language models (LLMs) to perform novel tasks without parameter updates by conditioning on a few input-output examples. However, collecting high-quality examples for new or challenging tasks can be costly and labor-intensive. In this work, we propose a cost-efficient two-stage pipeline that reduces reliance on LLMs for data labeling. Our approach first leverages readily available cross-task examples to prompt an LLM and pseudo-label a small set of target task instances. We then introduce a graph-based label propagation method that spreads label information to the remaining target examples without additional LLM queries. The resulting fully pseudo-labeled dataset is used to construct in-task demonstrations for ICL. This pipeline combines the flexibility of cross-task supervision with the scalability of LLM-free propagation. Experiments across five tasks demonstrate that our method achieves strong performance while lowering labeling costs.

Abstract--Sepsis is a leading cause of mortality in intensive care units (ICUs), yet existing research often relies on outdated datasets, non-reproducible preprocessing pipelines, and limited coverage of clinical interventions. We introduce MIMIC-Sepsis, a curated cohort and benchmark framework derived from the MIMIC-IV database, designed to support reproducible modeling of sepsis trajectories. Our cohort includes 35,239 ICU patients with time-aligned clinical variables and standardized treatment data, including vasopressors, fluids, mechanical ventilation and antibiotics. We describe a transparent preprocess-ing pipeline--based on Sepsis-3 criteria, structured imputation strategies, and treatment inclusion--and release it alongside benchmark tasks focused on early mortality prediction, length-of-stay estimation, and shock onset classification. Empirical results demonstrate that incorporating treatment variables substantially improves model performance, particularly for Transformer-based architectures. MIMIC-Sepsis serves as a robust platform for evaluating predictive and sequential models in critical care research. Sepsis is a life-threatening condition caused by the body's extreme response to an infection that can lead to organ failure and even death.

As machine learning (ML) models become increasingly deployed through cloud infrastructures, the confidentiality of user data during inference poses a significant security challenge. Homomorphic Encryption (HE) has emerged as a compelling cryptographic technique that enables computation on encrypted data, allowing predictions to be generated without decrypting sensitive inputs. However, the integration of HE within large scale cloud native pipelines remains constrained by high computational overhead, orchestration complexity, and model compatibility issues. This paper presents a systematic framework for the design and optimization of cloud native homomorphic encryption workflows that support privacy-preserving ML inference. The proposed architecture integrates containerized HE modules with Kubernetes-based orchestration, enabling elastic scaling and parallel encrypted computation across distributed environments. Furthermore, optimization strategies including ciphertext packing, polynomial modulus adjustment, and operator fusion are employed to minimize latency and resource consumption while preserving cryptographic integrity. Experimental results demonstrate that the proposed system achieves up to 3.2times inference acceleration and 40% reduction in memory utilization compared to conventional HE pipelines. These findings illustrate a practical pathway for deploying secure ML-as-a-Service (MLaaS) systems that guarantee data confidentiality under zero-trust cloud conditions.

With the development of artificial intelligence (AI) techniques, implementing AI-based techniques to improve wireless transceivers becomes an emerging research topic. Within this context, AI-based channel characterization and estimation become the focus since these methods have not been solved by traditional methods very well and have become the bottleneck of transceiver efficiency in large-scale orthogonal frequency division multiplexing (OFDM) systems. Specifically, by formulating channel estimation as a generative AI problem, generative AI methods such as diffusion models (DMs) can efficiently deal with rough initial estimations and have great potential to cooperate with traditional signal processing methods. This paper focuses on the transceiver design of OFDM systems based on DMs, provides an illustration of the potential of DMs in wireless transceivers, and points out the related research directions brought by DMs. We also provide a proof-of-concept case study of further adapting DMs for better wireless receiver performance.

As Large language models (LLMs) become increasingly integrated into our lives, their inherent social biases remain a pressing concern. Detecting and evaluating these biases can be challenging because they are often implicit rather than explicit in nature, so developing evaluation methods that assess the implicit knowledge representations of LLMs is essential. We present a novel word association network methodology for evaluating implicit biases in LLMs based on simulating semantic priming within LLM-generated word association networks. Our prompt-based approach taps into the implicit relational structures encoded in LLMs, providing both quantitative and qualitative assessments of bias. Unlike most prompt-based evaluation methods, our method enables direct comparisons between various LLMs and humans, providing a valuable point of reference and offering new insights into the alignment of LLMs with human cognition. To demonstrate the utility of our methodology, we apply it to both humans and several widely used LLMs to investigate social biases related to gender, religion, ethnicity, sexual orientation, and political party. Our results reveal both convergences and divergences between LLM and human biases, providing new perspectives on the potential risks of using LLMs. Our methodology contributes to a systematic, scalable, and generalizable framework for evaluating and comparing biases across multiple LLMs and humans, advancing the goal of transparent and socially responsible language technologies.

Hallucination remains one of the key obstacles to the reliable deployment of large language models (LLMs), particularly in real-world applications. Among various mitigation strategies, Retrieval-Augmented Generation (RAG) and reasoning enhancement have emerged as two of the most effective and widely adopted approaches, marking a shift from merely suppressing hallucinations to balancing creativity and reliability. However, their synergistic potential and underlying mechanisms for hallucination mitigation have not yet been systematically examined. This survey adopts an application-oriented perspective of capability enhancement to analyze how RAG, reasoning enhancement, and their integration in Agentic Systems mitigate hallucinations. We propose a taxonomy distinguishing knowledge-based and logic-based hallucinations, systematically examine how RAG and reasoning address each, and present a unified framework supported by real-world applications, evaluations, and benchmarks.

Personalized text generation requires models not only to produce coherent text but also to align with a target user's style, tone, and topical focus. Existing retrieval-augmented approaches such as LaMP and PGraphRAG enrich profiles with user and neighbor histories, but they stop at generation and often yield outputs that drift in tone, topic, or style. We present PerFine, a unified, training-free critique-refine framework that enhances personalization through iterative, profile-grounded feedback. In each iteration, an LLM generator produces a draft conditioned on the retrieved profile, and a critic LLM - also conditioned on the same profile - provides structured feedback on tone, vocabulary, sentence structure, and topicality. The generator then revises, while a novel knockout strategy retains the stronger draft across iterations. We further study additional inference-time strategies such as Best-of-N and Topic Extraction to balance quality and efficiency. Across Yelp, Goodreads, and Amazon datasets, PerFine consistently improves personalization over PGraphRAG, with GEval gains of +7-13%, steady improvements over 3-5 refinement iterations, and scalability with increasing critic size. These results highlight that post-hoc, profile-aware feedback offers a powerful paradigm for personalized LLM generation that is both training-free and model-agnostic.

The theory of training deep networks has become a central question of modern machine learning and has inspired many practical advancements. In particular, the gradient descent (GD) optimization algorithm has been extensively studied in recent years. A key assumption about GD has appeared in several recent works: the \emph{GD map is non-singular} -- it preserves sets of measure zero under preimages. Crucially, this assumption has been used to prove that GD avoids saddle points and maxima, and to establish the existence of a computable quantity that determines the convergence to global minima (both for GD and stochastic GD). However, the current literature either assumes the non-singularity of the GD map or imposes restrictive assumptions, such as Lipschitz smoothness of the loss (for example, Lipschitzness does not hold for deep ReLU networks with the cross-entropy loss) and restricts the analysis to GD with small step-sizes. In this paper, we investigate the neural network map as a function on the space of weights and biases. We also prove, for the first time, the non-singularity of the gradient descent (GD) map on the loss landscape of realistic neural network architectures (with fully connected, convolutional, or softmax attention layers) and piecewise analytic activations (which includes sigmoid, ReLU, leaky ReLU, etc.) for almost all step-sizes. Our work significantly extends the existing results on the convergence of GD and SGD by guaranteeing that they apply to practical neural network settings and has the potential to unlock further exploration of learning dynamics.

Multimodal large language models (MLLMs) have shown impressive capabilities in vision-language tasks such as reasoning segmentation, where models generate segmentation masks based on textual queries. While prior work has primarily focused on perturbing image inputs, semantically equivalent textual paraphrases-crucial in real-world applications where users express the same intent in varied ways-remain underexplored. To address this gap, we introduce a novel adversarial paraphrasing task: generating grammatically correct paraphrases that preserve the original query meaning while degrading segmentation performance. To evaluate the quality of adversarial paraphrases, we develop a comprehensive automatic evaluation protocol validated with human studies. Furthermore, we introduce SPARTA-a black-box, sentence-level optimization method that operates in the low-dimensional semantic latent space of a text autoencoder, guided by reinforcement learning. SPARTA achieves significantly higher success rates, outperforming prior methods by up to 2x on both the ReasonSeg and LLMSeg-40k datasets. We use SPARTA and competitive baselines to assess the robustness of advanced reasoning segmentation models. We reveal that they remain vulnerable to adversarial paraphrasing-even under strict semantic and grammatical constraints. All code and data will be released publicly upon acceptance.