Determinantal point processes (DPPs) offer a powerful approach to modeling diversity in many applications where the goal is to select a diverse subset. We study the problem of learning the parameters (the kernel matrix) of a DPP from labeled training data. We make two contributions. First, we show how to reparameterize a DPP's kernel matrix with multiple kernel functions, thus enhancing modeling flexibility. Second, we propose a novel parameter estimation technique based on the principle of large margin separation. In contrast to the state-of-the-art method of maximum likelihood estimation, our large-margin loss function explicitly models errors in selecting the target subsets, and it can be customized to trade off different types of errors (precision vs. recall). Extensive empirical studies validate our contributions, including applications on challenging document and video summarization, where flexibility in modeling the kernel matrix and balancing different errors is indispensable.

Identifying latent structure in large data matrices is essential for exploring biological processes. Here, we consider recovering gene co-expression networks from gene expression data, where each network encodes relationships between genes that are locally co-regulated by shared biological mechanisms. To do this, we develop a Bayesian statistical model for biclustering to infer subsets of co-regulated genes whose covariation may be observed in only a subset of the samples. Our biclustering method, BicMix, has desirable properties, including allowing overcomplete representations of the data, computational tractability, and jointly modeling unknown confounders and biological signals. Compared with related biclustering methods, BicMix recovers latent structure with higher precision across diverse simulation scenarios. Further, we develop a method to recover gene co-expression networks from the estimated sparse biclustering matrices. We apply BicMix to breast cancer gene expression data and recover a gene co-expression network that is differential across ER+ and ER- samples.

The Dirichlet process mixture (DPM) is a ubiquitous, flexible Bayesian nonparametric statistical model. However, full probabilistic inference in this model is analytically intractable, so that computationally intensive techniques such as Gibb's sampling are required. As a result, DPM-based methods, which have considerable potential, are restricted to applications in which computational resources and time for inference is plentiful. For example, they would not be practical for digital signal processing on embedded hardware, where computational resources are at a serious premium. Here, we develop simplified yet statistically rigorous approximate maximum a-posteriori (MAP) inference algorithms for DPMs. This algorithm is as simple as K-means clustering, performs in experiments as well as Gibb's sampling, while requiring only a fraction of the computational effort. Unlike related small variance asymptotics, our algorithm is non-degenerate and so inherits the "rich get richer" property of the Dirichlet process. It also retains a non-degenerate closed-form likelihood which enables standard tools such as cross-validation to be used. This is a well-posed approximation to the MAP solution of the probabilistic DPM model.

State-space models have been successfully used for more than fifty years in different areas of science and engineering. We present a procedure for efficient variational Bayesian learning of nonlinear state-space models based on sparse Gaussian processes. The result of learning is a tractable posterior over nonlinear dynamical systems. In comparison to conventional parametric models, we offer the possibility to straightforwardly trade off model capacity and computational cost whilst avoiding overfitting. Our main algorithm uses a hybrid inference approach combining variational Bayes and sequential Monte Carlo. We also present stochastic variational inference and online learning approaches for fast learning with long time series.

Identifying small subsets of features that are relevant for prediction and/or classification tasks is a central problem in machine learning and statistics. The feature selection task is especially important, and computationally difficult, for modern datasets where the number of features can be comparable to, or even exceed, the number of samples. Here, we show that feature selection with Bayesian inference takes a universal form and reduces to calculating the magnetizations of an Ising model, under some mild conditions. Our results exploit the observation that the evidence takes a universal form for strongly-regularizing priors --- priors that have a large effect on the posterior probability even in the infinite data limit. We derive explicit expressions for feature selection for generalized linear models, a large class of statistical techniques that include linear and logistic regression. We illustrate the power of our approach by analyzing feature selection in a logistic regression-based classifier trained to distinguish between the letters B and D in the notMNIST dataset.

Fetal ECG (FECG) telemonitoring is an important branch in telemedicine. The design of a telemonitoring system via a wireless body-area network with low energy consumption for ambulatory use is highly desirable. As an emerging technique, compressed sensing (CS) shows great promise in compressing/reconstructing data with low energy consumption. However, due to some specific characteristics of raw FECG recordings such as non-sparsity and strong noise contamination, current CS algorithms generally fail in this application. This work proposes to use the block sparse Bayesian learning (BSBL) framework to compress/reconstruct non-sparse raw FECG recordings. Experimental results show that the framework can reconstruct the raw recordings with high quality. Especially, the reconstruction does not destroy the interdependence relation among the multichannel recordings. This ensures that the independent component analysis decomposition of the reconstructed recordings has high fidelity. Furthermore, the framework allows the use of a sparse binary sensing matrix with much fewer nonzero entries to compress recordings. Particularly, each column of the matrix can contain only two nonzero entries. This shows the framework, compared to other algorithms such as current CS algorithms and wavelet algorithms, can greatly reduce code execution in CPU in the data compression stage.

We examine the recovery of block sparse signals and extend the framework in two important directions; one by exploiting signals' intra-block correlation and the other by generalizing signals' block structure. We propose two families of algorithms based on the framework of block sparse Bayesian learning (BSBL). One family, directly derived from the BSBL framework, requires knowledge of the block structure. Another family, derived from an expanded BSBL framework, is based on a weaker assumption on the block structure, and can be used when the block structure is completely unknown. Using these algorithms we show that exploiting intra-block correlation is very helpful in improving recovery performance. These algorithms also shed light on how to modify existing algorithms or design new ones to exploit such correlation and improve performance.

This paper develops a mathematical and computational framework for analyzing the expected performance of Bayesian data fusion, or joint statistical inference, within a sensor network. We use variational techniques to obtain the posterior expectation as the optimal fusion rule under a deterministic constraint and a quadratic cost, and study the smoothness and other properties of its classification performance. For a certain class of fusion problems, we prove that this fusion rule is also optimal in a much wider sense and satisfies strong asymptotic convergence results. We show how these results apply to a variety of examples with Gaussian, exponential and other statistics, and discuss computational methods for determining the fusion system's performance in more general, large-scale problems. These results are motivated by studying the performance of fusing multi-modal radar and acoustic sensors for detecting explosive substances, but have broad applicability to other Bayesian decision problems.

This paper examines a general class of noisy matrix completion tasks where the goal is to estimate a matrix from observations obtained at a subset of its entries, each of which is subject to random noise or corruption. Our specific focus is on settings where the matrix to be estimated is well-approximated by a product of two (a priori unknown) matrices, one of which is sparse. Such structural models - referred to here as "sparse factor models" - have been widely used, for example, in subspace clustering applications, as well as in contemporary sparse modeling and dictionary learning tasks. Our main theoretical contributions are estimation error bounds for sparsity-regularized maximum likelihood estimators for problems of this form, which are applicable to a number of different observation noise or corruption models. Several specific implications are examined, including scenarios where observations are corrupted by additive Gaussian noise or additive heavier-tailed (Laplace) noise, Poisson-distributed observations, and highly-quantized (e.g., one-bit) observations. We also propose a simple algorithmic approach based on the alternating direction method of multipliers for these tasks, and provide experimental evidence to support our error analyses.

In this paper we address the task of extracting risk events and probabilities from free text, focusing in particular on the biomedical domain. While our initial motivation is to enable the determination of the parameters of a Bayesian belief network, our approach is not specific to that use case. We are the first to investigate this task as a sequence tagging problem where we label spans of text as events A or B that are then used to construct probability statements of the form P(A|B)=x. We show that our approach significantly outperforms an entity extraction baseline on a new annotated medical risk event corpus. We also explore semi-supervised methods that lead to modest improvement, encouraging further work in this direction.