Alzheimer's disease is a progressive, neurodegenerative disorder that causes memory loss and cognitive decline. While there has been extensive research in applying deep learning models to Alzheimer's prediction tasks, these models remain limited by lack of available labeled data, poor generalization across datasets, and inflexibility to varying numbers of input scans and time intervals between scans. In this study, we adapt three state-of-the-art temporal self-supervised learning (SSL) approaches for 3D brain MRI analysis, and add novel extensions designed to handle variable-length inputs and learn robust spatial features. We aggregate four publicly available datasets comprising 3,161 patients for pre-training, and show the performance of our model across multiple Alzheimer's prediction tasks including diagnosis classification, conversion detection, and future conversion prediction. Importantly, our SSL model implemented with temporal order prediction and contrastive learning outperforms supervised learning on six out of seven downstream tasks. It demonstrates adaptability and generalizability across tasks and number of input images with varying time intervals, highlighting its capacity for robust performance across clinical applications.

Anti - money laundering (AML) actions and measurements are among the priorities of financial institutions, for which machine learning (ML) has shown to have a high potential. In this paper, we propose a comprehensive and systematic approach for developing ML pipelines to identify high - risk bank clients in a dataset curated for Task 1 of the University of Toro nto 2023 - 2024 Institute for Management and Innovation (IMI) Big Data and Artificial Intelligence Competition. The dataset included 195,789 customer IDs, and we employed a 16 - step design and statistical analysis to ensure the final pipeline was robust. We also framed the data in a SQLite database, developed SQL - based feature engineering algorithms, connected our pre - trained model to the database, and made i t inference - ready, and provided explainable artificial intelligence (XAI) modules to derive feature importance. Our pipeline achieved a mean area under the receiver operating characteristic curve (AUROC) of 0.961 with a standard deviation (SD) of 0.005. Th e proposed pipeline achieved second place in the competition. Introduction In the contemporary financial landscape, money laundering represents a formidable challenge, compelling both financial institutions and regulatory bodies to seek innovative solutions. The integration of machine learning (ML) into anti - money laundering (AML) efforts has emerged as a promising avenue to enhance the detection and prevention of illicit financial activities. This paper investigates the technical considerations in employing supervised learning techniques to accurately identify high - risk bank clie nts, a critical component in the battle against money laundering. The utilization of ML for detecting money laundering transactions has shown significant promise. Jullum et al. developed an ML model that outperforms traditional systems by prioritizing transactions for manual investigation, using historic data from Norway ' s largest bank, DNB [1] .

Timed regular expressions serve as a formalism for specifying real-time behaviors of Cyber-Physical Systems. In this paper, we consider the synthesis of timed regular expressions, focusing on generating a timed regular expression consistent with a given set of system behaviors including positive and negative examples, i.e., accepting all positive examples and rejecting all negative examples. We first prove the decidability of the synthesis problem through an exploration of simple timed regular expressions. Subsequently, we propose our method of generating a consistent timed regular expression with minimal length, which unfolds in two steps. The first step is to enumerate and prune candidate parametric timed regular expressions. In the second step, we encode the requirement that a candidate generated by the first step is consistent with the given set into a Satisfiability Modulo Theories (SMT) formula, which is consequently solved to determine a solution to parametric time constraints. Finally, we evaluate our approach on benchmarks, including randomly generated behaviors from target timed models and a case study.

Automated speaking assessment (ASA) on opinion expressions is often hampered by the scarcity of labeled recordings, which restricts prompt diversity and undermines scoring reliability. To address this challenge, we propose a novel training paradigm that leverages a large language models (LLM) to generate diverse responses of a given proficiency level, converts responses into synthesized speech via speaker-aware text-to-speech synthesis, and employs a dynamic importance loss to adaptively reweight training instances based on feature distribution differences between synthesized and real speech. Subsequently, a multimodal large language model integrates aligned textual features with speech signals to predict proficiency scores directly. Experiments conducted on the L TTC dataset show that our approach outperforms methods relying on real data or conventional augmentation, effectively mitigating low-resource constraints and enabling ASA on opinion expressions with cross-modal information. Index T erms: Automated speaking assessment, Opinion Expression, Data Augmentation 1. Introduction In recent years, technologies for computer-assisted language learning (CALL), such as automated speaking assessment (ASA), have made significant strides to meet the growing demand for scalable and objective evaluation of second-language (L2) speaking proficiency in both academic and professional contexts [1, 2, 3].

For Relation Extraction (RE), the manual annotation of training data may be prohibitively expensive, since the sentences that contain the target relations in texts can be very scarce and difficult to find. It is therefore beneficial to develop an efficient method that can automatically extract training instances from unlabeled texts for training RE models. Recently, large language models (LLMs) have been adopted in various natural language processing tasks, with RE also benefiting from their advances. However, when leveraging LLMs for RE with predefined relation categories, two key challenges arise. First, in a multi-class classification setting, LLMs often struggle to comprehensively capture the semantics of every relation, leading to suboptimal results. Second, although employing binary classification for each relation individually can mitigate this issue, it introduces significant computational overhead, resulting in impractical time complexity for real-world applications. Therefore, this paper proposes a framework called M-BRe to extract training instances from unlabeled texts for RE. It utilizes three modules to combine the advantages of both of the above classification approaches: Relation Grouping, Relation Extraction, and Label Decision. Extensive experiments confirm its superior capability in discovering high-quality training samples from unlabeled texts for RE.

Human Activity Recognition (HAR) has seen significant advancements with the adoption of deep learning techniques, yet challenges remain in terms of data requirements, reliability and robustness. This paper explores a novel application of Ensemble Distribution Distillation (EDD) within a self-supervised learning framework for HAR aimed at overcoming these challenges. By leveraging unlabeled data and a partially supervised training strategy, our approach yields an increase in predictive accuracy, robust estimates of uncertainty, and substantial increases in robustness against adversarial perturbation; thereby significantly improving reliability in real-world scenarios without increasing computational complexity at inference. We demonstrate this with an evaluation on several publicly available datasets. The contributions of this work include the development of a self-supervised EDD framework, an innovative data augmentation technique designed for HAR, and empirical validation of the proposed method's effectiveness in increasing robustness and reliability.

Self-supervised learning (SSL) has emerged as a powerful paradigm for representation learning by optimizing geometric objectives--such as invariance to augmentations, variance preservation, and feature decorrelation--without requiring labels. However, most existing methods operate in Euclidean space, limiting their ability to capture nonlinear dependencies and geometric structures. In this work, we propose Kernel VICReg, a novel self-supervised learning framework that lifts the VICReg objective into a Reproducing Kernel Hilbert Space (RKHS). By kernelizing each term of the loss-variance, invariance, and covariance--we obtain a general formulation that operates on double-centered kernel matrices and Hilbert-Schmidt norms, enabling nonlinear feature learning without explicit mappings. We demonstrate that Kernel VICReg not only avoids representational collapse but also improves performance on tasks with complex or small-scale data. Empirical evaluations across MNIST, CIFAR-10, STL-10, TinyImageNet, and ImageNet100 show consistent gains over Euclidean VICReg, with particularly strong improvements on datasets where nonlinear structures are prominent. UMAP visualizations further confirm that kernel-based embeddings exhibit better isometry and class separation. Our results suggest that kernelizing SSL objectives is a promising direction for bridging classical kernel methods with modern representation learning.

In this paper, we introduce the Protocol Genome, a self-supervised learning system that learns correlations from DICOM headers and achieves AUROC 0.901 (vs 0.847 baseline) and ECE 0.036 (vs 0.058) on fully held-out external validation. Our method also improves calibration and robustness across modalities (CT, MRI, CXR) and vendors. Clinical imaging is funneled through PACS/DICOM, where procedure choices (scanner make/model, sequence, kernel, kVp, TR/TE, and slice thickness) have consequences for contrast, noise, and artifact. These latent confounders impede the generalization of image-only networks across sites. We consider structured DICOM headers as a label and learn protocol-aware but clinically robust image representations. Protocol Genome obtains tokenized embeddings of de-identified header fields and models them along with image features using: (1) protocol-image contrastive learning, (2) masked protocol prediction, and (3) protocol-protocol translation. With 1.26M studies (7 health systems, 31 scanners, 3 vendors; CT, MR, CR/DR), we experiment on: (A) chest CT triage for PE, (B) brain MRI glioma grading, and (C) chest radiograph cardiomegaly detection. Relative to strong SSL baselines (SimCLR, MAE) as well as ImageNet transfer, Protocol Genome (+0.046: PE, +0.058: glioma, +0.041: cardiomegaly) is associated with higher external AUROC; 25-37% calibration improvements are obtained (p < 0.01, DeLong tests). While the gains may be task-dependent, they are preserved with 10-20% of labeled data. From a clinical point of view, the technique reduces false positives at protocol borders and is applicable in a PACS (DICOM C-FIND/C-MOVE, DICOMweb QIDO/WADO). We publish a model card and deployment guide, complete with both de-identification and bias audits.

Aerial remote sensing using multispectral and RGB imagers has provided a critical impetus to precision agriculture. Analysis of the hyperspectral images with limited or no labels is challenging. This paper focuses on self-supervised learning to create neural network embeddings reflecting vegetation properties of trees from aerial hyperspectral images of crop fields. Experimental results demonstrate that a constructed tree representation, using a vegetation property-related embedding space, performs better in downstream machine learning tasks compared to the direct use of hyperspectral vegetation properties as tree representations.

Multivariate time series (MTS) are ubiquitous in domains such as healthcare, climate science, and industrial monitoring, but their high dimensionality, limited labeled data, and non-stationary nature pose significant challenges for conventional machine learning methods. While recent self-supervised learning (SSL) approaches mitigate label scarcity by data augmentations or time point-based contrastive strategy, they neglect the intrinsic periodic structure of MTS and fail to capture the dynamic evolution of latent states. We propose PLanTS, a periodicity-aware self-supervised learning framework that explicitly models irregular latent states and their transitions. We first designed a period-aware multi-granularity patching mechanism and a generalized contrastive loss to preserve both instance-level and state-level similarities across multiple temporal resolutions. To further capture temporal dynamics, we design a next-transition prediction pretext task that encourages representations to encode predictive information about future state evolution. We evaluate PLanTS across a wide range of downstream tasks-including multi-class and multi-label classification, forecasting, trajectory tracking and anomaly detection. PLanTS consistently improves the representation quality over existing SSL methods and demonstrates superior runtime efficiency compared to DTW-based methods.