Although biomedical entity linking (BioEL) has made significant progress with pre-trained language models, challenges still exist for fine-grained and long-tailed entities. To address these challenges, we present BioELQA, a novel model that treats Biomedical Entity Linking as Multiple Choice Question Answering. BioELQA first obtains candidate entities with a fast retriever, jointly presents the mention and candidate entities to a generator, and then outputs the predicted symbol associated with its chosen entity. This formulation enables explicit comparison of different candidate entities, thus capturing fine-grained interactions between mentions and entities, as well as among entities themselves. To improve generalization for long-tailed entities, we retrieve similar labeled training instances as clues and concatenate the input with retrieved instances for the generator. Extensive experimental results show that BioELQA outperforms state-of-the-art baselines on several datasets.

Speech production is a complex phenomenon, wherein the brain orchestrates a sequence of processes involving thought processing, motor planning, and the execution of articulatory movements. However, this intricate execution of various processes is susceptible to influence and disruption by various neurodegenerative pathological speech disorders, such as Parkinsons' disease, resulting in dysarthria, apraxia, and other conditions. These disorders lead to pathological speech characterized by abnormal speech patterns and imprecise articulation. Diagnosing these speech disorders in clinical settings typically involves auditory perceptual tests, which are time-consuming, and the diagnosis can vary among clinicians based on their experiences, biases, and cognitive load during the diagnosis. Additionally, unlike neurotypical speakers, patients with speech pathologies or impairments are unable to access various virtual assistants such as Alexa, Siri, etc. To address these challenges, several automatic pathological speech detection (PSD) approaches have been proposed. These approaches aim to provide efficient and accurate detection of speech disorders, thereby facilitating timely intervention and support for individuals affected by these conditions. These approaches mainly vary in two aspects: the input representations utilized and the classifiers employed. Due to the limited availability of data, the performance of detection remains subpar. Self-supervised learning (SSL) embeddings, such as wav2vec2, and their multilingual versions, are being explored as a promising avenue to improve performance. These embeddings leverage self-supervised learning techniques to extract rich representations from audio data, thereby offering a potential solution to address the limitations posed by the scarcity of labeled data.

The evolution of artificial intelligence (AI) has profoundly impacted human society, driving significant advancements in multiple sectors. Yet, the escalating demands on AI have highlighted the limitations of AI's current offerings, catalyzing a movement towards Artificial General Intelligence (AGI). AGI, distinguished by its ability to execute diverse real-world tasks with efficiency and effectiveness comparable to human intelligence, reflects a paramount milestone in AI evolution. While existing works have summarized specific recent advancements of AI, they lack a comprehensive discussion of AGI's definitions, goals, and developmental trajectories. Different from existing survey papers, this paper delves into the pivotal questions of our proximity to AGI and the strategies necessary for its realization through extensive surveys, discussions, and original perspectives. We start by articulating the requisite capability frameworks for AGI, integrating the internal, interface, and system dimensions. As the realization of AGI requires more advanced capabilities and adherence to stringent constraints, we further discuss necessary AGI alignment technologies to harmonize these factors. Notably, we emphasize the importance of approaching AGI responsibly by first defining the key levels of AGI progression, followed by the evaluation framework that situates the status-quo, and finally giving our roadmap of how to reach the pinnacle of AGI. Moreover, to give tangible insights into the ubiquitous impact of the integration of AI, we outline existing challenges and potential pathways toward AGI in multiple domains. In sum, serving as a pioneering exploration into the current state and future trajectory of AGI, this paper aims to foster a collective comprehension and catalyze broader public discussions among researchers and practitioners on AGI.

A fundamental problem in supervised learning is to find a good set of features or distance measures. If the new set of features is of lower dimensionality and can be obtained by a simple transformation of the original data, they can make the model understandable, reduce overfitting, and even help to detect distribution drift. We propose a supervised dimensionality reduction method Gradient Boosting Mapping (GBMAP), where the outputs of weak learners -- defined as one-layer perceptrons -- define the embedding. We show that the embedding coordinates provide better features for the supervised learning task, making simple linear models competitive with the state-of-the-art regressors and classifiers. We also use the embedding to find a principled distance measure between points. The features and distance measures automatically ignore directions irrelevant to the supervised learning task. We also show that we can reliably detect out-of-distribution data points with potentially large regression or classification errors. GBMAP is fast and works in seconds for dataset of million data points or hundreds of features. As a bonus, GBMAP provides a regression and classification performance comparable to the state-of-the-art supervised learning methods.

This paper addresses the problem of self-supervised general-purpose audio representation learning. We explore the use of Joint-Embedding Predictive Architectures (JEPA) for this task, which consists of splitting an input mel-spectrogram into two parts (context and target), computing neural representations for each, and training the neural network to predict the target representations from the context representations. We investigate several design choices within this framework and study their influence through extensive experiments by evaluating our models on various audio classification benchmarks, including environmental sounds, speech and music downstream tasks. We focus notably on which part of the input data is used as context or target and show experimentally that it significantly impacts the model's quality. In particular, we notice that some effective design choices in the image domain lead to poor performance on audio, thus highlighting major differences between these two modalities.

Data-driven, machine learning (ML) models of atomistic interactions are often based on flexible and non-physical functions that can relate nuanced aspects of atomic arrangements into predictions of energies and forces. As a result, these potentials are as good as the training data (usually results of so-called ab initio simulations) and we need to make sure that we have enough information for a model to become sufficiently accurate, reliable and transferable. The main challenge stems from the fact that descriptors of chemical environments are often sparse high-dimensional objects without a well-defined continuous metric. Therefore, it is rather unlikely that any ad hoc method of choosing training examples will be indiscriminate, and it will be easy to fall into the trap of confirmation bias, where the same narrow and biased sampling is used to generate train- and test- sets. We will demonstrate that classical concepts of statistical planning of experiments and optimal design can help to mitigate such problems at a relatively low computational cost. The key feature of the method we will investigate is that they allow us to assess the informativeness of data (how much we can improve the model by adding/swapping a training example) and verify if the training is feasible with the current set before obtaining any reference energies and forces -- a so-called off-line approach. In other words, we are focusing on an approach that is easy to implement and doesn't require sophisticated frameworks that involve automated access to high-performance computational (HPC).

Addressing the challenge of low-resource information extraction remains an ongoing issue due to the inherent information scarcity within limited training examples. Existing data augmentation methods, considered potential solutions, struggle to strike a balance between weak augmentation (e.g., synonym augmentation) and drastic augmentation (e.g., conditional generation without proper guidance). This paper introduces a novel paradigm that employs targeted augmentation and back validation to produce augmented examples with enhanced diversity, polarity, accuracy, and coherence. Extensive experimental results demonstrate the effectiveness of the proposed paradigm. Furthermore, identified limitations are discussed, shedding light on areas for future improvement.

Abstract--The classification of sleep stages is a pivotal aspect of diagnosing sleep disorders and evaluating sleep quality. However, the conventional manual scoring process, conducted by clinicians, is time-consuming and prone to human bias. Recent advancements in deep learning have substantially propelled the automation of sleep stage classification. Nevertheless, challenges persist, including the need for large datasets with labels and the inherent biases in human-generated annotations. This paper introduces NeuroNet, a self-supervised learning (SSL) framework designed to effectively harness unlabeled single-channel sleep electroencephalogram (EEG) signals by integrating contrastive learning tasks and masked prediction tasks. NeuroNet demonstrates superior performance over existing SSL methodologies through extensive experimentation conducted across three polysomnography (PSG) datasets. Additionally, this study proposes a Mamba-based temporal context module to capture the relationships among diverse EEG epochs. Combining NeuroNet with the Mamba-based temporal context module has demonstrated the capability to achieve, or even surpass, the performance of the latest supervised learning methodologies, even with a limited amount of labeled data. This study is expected to establish a new benchmark in sleep stage classification, promising to guide future research and applications in the field of sleep analysis.

General policies represent reactive strategies for solving large families of planning problems like the infinite collection of solvable instances from a given domain. Methods for learning such policies from a collection of small training instances have been developed successfully for classical domains. In this work, we extend the formulations and the resulting combinatorial methods for learning general policies over fully observable, non-deterministic (FOND) domains. We also evaluate the resulting approach experimentally over a number of benchmark domains in FOND planning, present the general policies that result in some of these domains, and prove their correctness. The method for learning general policies for FOND planning can actually be seen as an alternative FOND planning method that searches for solutions, not in the given state space but in an abstract space defined by features that must be learned as well.

Self-supervised learning (SSL) has emerged as a promising technique for medical image analysis due to its ability to learn without annotations. However, despite the promising potential, conventional SSL methods encounter limitations, including challenges in achieving semantic alignment and capturing subtle details. This leads to suboptimal representations, which fail to accurately capture the underlying anatomical structures and pathological details. In response to these constraints, we introduce a novel SSL framework OPTiML, employing optimal transport (OT), to capture the dense semantic invariance and fine-grained details, thereby enhancing the overall effectiveness of SSL in medical image representation learning. The core idea is to integrate OT with a cross-viewpoint semantics infusion module (CV-SIM), which effectively captures complex, fine-grained details inherent in medical images across different viewpoints. In addition to the CV-SIM module, OPTiML imposes the variance and covariance regularizations within OT framework to force the model focus on clinically relevant information while discarding less informative features. Through these, the proposed framework demonstrates its capacity to learn semantically rich representations that can be applied to various medical imaging tasks. To validate its effectiveness, we conduct experimental studies on three publicly available datasets from chest X-ray modality. Our empirical results reveal OPTiML's superiority over state-of-the-art methods across all evaluated tasks.