Medical texts, particularly electronic medical records (EMRs), are a cornerstone of modern healthcare, capturing critical information about patient care, diagnoses, and treatments. These texts hold immense potential for advancing clinical decision-making and healthcare analytics. However, their unstructured nature, domain-specific language, and variability across contexts make automated understanding an intricate challenge. Despite the advancements in natural language processing, existing methods often treat all data as equally challenging, ignoring the inherent differences in complexity across clinical records. This oversight limits the ability of models to effectively generalize and perform well on rare or complex cases. In this paper, we present TACL (Threshold-Adaptive Curriculum Learning), a novel framework designed to address these challenges by rethinking how models interact with medical texts during training. Inspired by the principle of progressive learning, TACL dynamically adjusts the training process based on the complexity of individual samples. By categorizing data into difficulty levels and prioritizing simpler cases early in training, the model builds a strong foundation before tackling more complex records. By applying TACL to multilingual medical data, including English and Chinese clinical records, we observe significant improvements across diverse clinical tasks, including automatic ICD coding, readmission prediction and TCM syndrome differentiation. TACL not only enhances the performance of automated systems but also demonstrates the potential to unify approaches across disparate medical domains, paving the way for more accurate, scalable, and globally applicable medical text understanding solutions.

Automated International Classification of Diseases (ICD) coding assigns standardized diagnosis and procedure codes to clinical records, playing a critical role in healthcare systems. However, existing methods face challenges such as semantic gaps between clinical text and ICD codes, poor performance on rare and long-tail codes, and limited interpretability. To address these issues, we propose TraceCoder, a novel framework integrating multi-source external knowledge to enhance traceability and explainability in ICD coding. TraceCoder dynamically incorporates diverse knowledge sources, including UMLS, Wikipedia, and large language models (LLMs), to enrich code representations, bridge semantic gaps, and handle rare and ambiguous codes. It also introduces a hybrid attention mechanism to model interactions among labels, clinical context, and knowledge, improving long-tail code recognition and making predictions interpretable by grounding them in external evidence. Experiments on MIMIC-III-ICD9, MIMIC-IV-ICD9, and MIMIC-IV-ICD10 datasets demonstrate that TraceCoder achieves state-of-the-art performance, with ablation studies validating the effectiveness of its components. TraceCoder offers a scalable and robust solution for automated ICD coding, aligning with clinical needs for accuracy, interpretability, and reliability.

This paper studies policy transfer, one of the well-known transfer learning techniques adopted in large language models, for two classes of continuous-time reinforcement learning problems. In the first class of continuous-time linear-quadratic systems with Shannon's entropy regularization (a.k.a. LQRs), we fully exploit the Gaussian structure of their optimal policy and the stability of their associated Riccati equations. In the second class where the system has possibly non-linear and bounded dynamics, the key technical component is the stability of diffusion SDEs which is established by invoking the rough path theory. Our work provides the first theoretical proof of policy transfer for continuous-time RL: an optimal policy learned for one RL problem can be used to initialize the search for a near-optimal policy in a closely related RL problem, while maintaining the convergence rate of the original algorithm. To illustrate the benefit of policy transfer for RL, we propose a novel policy learning algorithm for continuous-time LQRs, which achieves global linear convergence and local super-linear convergence. As a byproduct of our analysis, we derive the stability of a concrete class of continuous-time score-based diffusion models via their connection with LQRs.

Fully open multimodal large language models (MLLMs) currently lag behind proprietary counterparts, primarily due to a significant gap in data quality for supervised fine-tuning (SFT). Existing open-source datasets are often plagued by widespread noise and a critical deficit in complex reasoning data, such as Chain-of-Thought (CoT), which hinders the development of advanced model capabilities. Addressing these challenges, our work makes three primary contributions. First, we introduce Honey-Data-15M, a new SFT dataset comprising approximately 15 million QA pairs, processed through multiple cleaning techniques and enhanced with a novel dual-level (short and long) CoT enrichment strategy. Second, we introduce HoneyPipe, the data curation pipeline, and its underlying framework DataStudio, providing the community with a transparent and adaptable methodology for data curation that moves beyond static dataset releases. Finally, to validate our dataset and pipeline, we train Bee-8B, an 8B model on Honey-Data-15M. Experiments show that Bee-8B establishes a new state-of-the-art (SOTA) for fully open MLLMs, achieving performance that is competitive with, and in some cases surpasses, recent semi-open models such as InternVL3.5-8B. Our work delivers to the community a suite of foundational resources, including: the Honey-Data-15M corpus; the full-stack suite comprising HoneyPipe and DataStudio; training recipes; an evaluation harness; and the model weights. This effort demonstrates that a principled focus on data quality is a key pathway to developing fully open MLLMs that are highly competitive with their semi-open counterparts.

We present the Federated Inference Resource Scheduling Toolkit (FIRST), a framework enabling Inference-as-a-Service across distributed High-Performance Computing (HPC) clusters. FIRST provides cloud-like access to diverse AI models, like Large Language Models (LLMs), on existing HPC infrastructure. Leveraging Globus Auth and Globus Compute, the system allows researchers to run parallel inference workloads via an OpenAI-compliant API on private, secure environments. This cluster-agnostic API allows requests to be distributed across federated clusters, targeting numerous hosted models. FIRST supports multiple inference backends (e.g., vLLM), auto-scales resources, maintains "hot" nodes for low-latency execution, and offers both high-throughput batch and interactive modes. The framework addresses the growing demand for private, secure, and scalable AI inference in scientific workflows, allowing researchers to generate billions of tokens daily on-premises without relying on commercial cloud infrastructure.

As virtual reality (VR) devices become increasingly integrated into everyday settings, a growing number of users without prior experience will engage with VR systems. Automatically detecting a user's familiarity with VR as an interaction medium enables real-time, adaptive training and interface adjustments, minimizing user frustration and improving task performance. In this study, we explore the automatic detection of VR familiarity by analyzing hand movement patterns during a passcode-based door-opening task, which is a well-known interaction in collaborative virtual environments such as meeting rooms, offices, and healthcare spaces. While novice users may lack prior VR experience, they are likely to be familiar with analogous real-world tasks involving keypad entry. We conducted a pilot study with 26 participants, evenly split between experienced and inexperienced VR users, who performed tasks using both controller-based and hand-tracking interactions. Our approach uses state-of-the-art deep classifiers for automatic VR familiarity detection, achieving the highest accuracies of 92.05% and 83.42% for hand-tracking and controller-based interactions, respectively. In the cross-device evaluation, where classifiers trained on controller data were tested using hand-tracking data, the model achieved an accuracy of 78.89%. The integration of both modalities in the mixed-device evaluation obtained an accuracy of 94.19%. Our results underline the promise of using hand movement biometrics for the real-time detection of user familiarity in critical VR applications, paving the way for personalized and adaptive VR experiences.

Graph Neural Networks (GNNs) have demonstrated remarkable success in node classification tasks over relational data, yet their effectiveness often depends on the availability of complete node features. In many real-world scenarios, however, feature matrices are highly sparse or contain sensitive information, leading to degraded performance and increased privacy risks. Furthermore, direct exposure of information can result in unintended data leakage, enabling adversaries to infer sensitive information. To address these challenges, we propose a novel Multi-view Feature Propagation (MFP) framework that enhances node classification under feature sparsity while promoting privacy preservation. MFP extends traditional Feature Propagation (FP) by dividing the available features into multiple Gaussian-noised views, each propagating information independently through the graph topology. The aggregated representations yield expressive and robust node embeddings. This framework is novel in two respects: it introduces a mechanism that improves robustness under extreme sparsity, and it provides a principled way to balance utility with privacy. Extensive experiments conducted on graph datasets demonstrate that MFP outperforms state-of-the-art baselines in node classification while substantially reducing privacy leakage. Moreover, our analysis demonstrates that propagated outputs serve as alternative imputations rather than reconstructions of the original features, preserving utility without compromising privacy. A comprehensive sensitivity analysis further confirms the stability and practical applicability of MFP across diverse scenarios. Overall, MFP provides an effective and privacy-aware framework for graph learning in domains characterized by missing or sensitive features.

Large Language Models (LLMs) have emerged as transformative tools for natural language understanding and user intent resolution, enabling tasks such as translation, summarization, and, increasingly, the orchestration of complex workflows. This development signifies a paradigm shift from conventional, GUI-driven user interfaces toward intuitive, language-first interaction paradigms. Rather than manually navigating applications, users can articulate their objectives in natural language, enabling LLMs to orchestrate actions across multiple applications in a dynamic and contextual manner. However, extant implementations frequently rely on cloud-based proprietary models, which introduce limitations in terms of privacy, autonomy, and scalability. For language-first interaction to become a truly robust and trusted interface paradigm, local deployment is not merely a convenience; it is an imperative. This limitation underscores the importance of evaluating the feasibility of locally deployable, open-source, and open-access LLMs as foundational components for future intent-based operating systems. In this study, we examine the capabilities of several open-source and open-access models in facilitating user intention resolution through machine assistance. A comparative analysis is conducted against OpenAI's proprietary GPT-4-based systems to assess performance in generating workflows for various user intentions. The present study offers empirical insights into the practical viability, performance trade-offs, and potential of open LLMs as autonomous, locally operable components in next-generation operating systems. The results of this study inform the broader discussion on the decentralization and democratization of AI infrastructure and point toward a future where user-device interaction becomes more seamless, adaptive, and privacy-conscious through locally embedded intelligence.

Predicting the fitness impact of mutations is central to protein engineering but constrained by limited assays relative to the size of sequence space. Protein language models (pLMs) trained with masked language modeling (MLM) exhibit strong zero-shot fitness prediction; we provide a unifying view by interpreting natural evolution as implicit reward maximization and MLM as inverse reinforcement learning (IRL), in which extant sequences act as expert demonstrations and pLM log-odds serve as fitness estimates. Building on this perspective, we introduce EvoIF, a lightweight model that integrates two complementary sources of evolutionary signal: (i) within-family profiles from retrieved homologs and (ii) cross-family structural-evolutionary constraints distilled from inverse folding logits. EvoIF fuses sequence-structure representations with these profiles via a compact transition block, yielding calibrated probabilities for log-odds scoring. On ProteinGym (217 mutational assays; >2.5M mutants), EvoIF and its MSA-enabled variant achieve state-of-the-art or competitive performance while using only 0.15% of the training data and fewer parameters than recent large models. Ablations confirm that within-family and cross-family profiles are complementary, improving robustness across function types, MSA depths, taxa, and mutation depths. The codes will be made publicly available at https://github.com/aim-uofa/EvoIF.

Mental health communication in India is linguistically fragmented, culturally diverse, and often underrepresented in clinical NLP. Current health ontologies and mental health resources are dominated by diagnostic frameworks centered on English or Western culture, leaving a gap in representing patient distress expressions in Indian languages. We propose cross-linguistic graphs of patient stress expressions (CL-PDE), a framework for building cross-lingual mental health ontologies through graph-based methods that capture culturally embedded expressions of distress, align them across languages, and link them with clinical terminology. Our approach addresses critical gaps in healthcare communication by grounding AI systems in culturally valid representations, allowing more inclusive and patient-centric NLP tools for mental health care in multilingual contexts.