Abstract--Autonomous V ehicles (A Vs) are poised to revolutionize emergency services by enabling faster, safer, and more efficient responses. This transformation is driven by advances in Artificial Intelligence (AI), particularly Reinforcement Learning (RL), which allows A Vs to navigate complex environments and make critical decisions in real time. However, conventional RL paradigms often suffer from poor sample efficiency and lack adaptability in dynamic emergency scenarios. This paper reviews next-generation A V optimization strategies to address these limitations. We analyze the shift from conventional RL to Diffusion Model (DM)-augmented RL, which enhances policy robustness through synthetic data generation, albeit with increased computational cost. Additionally, we explore the emerging paradigm of Large Language Model (LLM)-assisted In-Context Learning (ICL), which offers a lightweight and interpretable alternative by enabling rapid, on-the-fly adaptation without retraining. By reviewing the state of the art in A V intelligence, DM-augmented RL, and LLM-assisted ICL, this paper provides a critical framework for understanding the next generation of autonomous emergency response systems from a Generative AI perspective. Autonomous vehicles (A Vs) are poised to transform emergency services by enabling faster, safer, and more intelligent responses. Uncrewed Aerial V ehicles (UA Vs), as key enablers within the A V ecosystem, provide rapid deployment and precise mobility. They can serve as both aerial base stations and data collectors, enhancing connectivity and information gathering for A V operations.

Healthcare federated learning requires strong privacy guarantees while maintaining computational efficiency across resource-constrained medical institutions. This paper presents MedHE, a novel framework combining adaptive gradient sparsification with CKKS homomorphic encryption to enable privacy-preserving collaborative learning on sensitive medical data. Our approach introduces a dynamic threshold mechanism with error compensation for top-k gradient selection, achieving 97.5 percent communication reduction while preserving model utility. We provide formal security analysis under Ring Learning with Errors assumptions and demonstrate differential privacy guarantees with epsilon less than or equal to 1.0. Statistical testing across 5 independent trials shows MedHE achieves 89.5 percent plus or minus 0.8 percent accuracy, maintaining comparable performance to standard federated learning (p=0.32) while reducing communication from 1277 MB to 32 MB per training round. Comprehensive evaluation demonstrates practical feasibility for real-world medical deployments with HIPAA compliance and scalability to 100 plus institutions.

Fairness in AI-driven stress detection is critical for equitable mental healthcare, yet existing models frequently exhibit gender bias, particularly in data-scarce scenarios. To address this, we propose FairM2S, a fairness-aware meta-learning framework for stress detection leveraging audio-visual data. FairM2S integrates Equalized Odds constraints during both meta-training and adaptation phases, employing adversarial gradient masking and fairness-constrained meta-updates to effectively mitigate bias. Evaluated against five state-of-the-art baselines, FairM2S achieves 78.1% accuracy while reducing the Equal Opportunity to 0.06, demonstrating substantial fairness gains. We also release SAVSD, a smartphone-captured dataset with gender annotations, designed to support fairness research in low-resource, real-world contexts. Together, these contributions position FairM2S as a state-of-the-art approach for equitable and scalable few-shot stress detection in mental health AI. We release our dataset and FairM2S publicly with this paper.

End-to-end autonomous driving systems (ADSs), with their strong capabilities in environmental perception and generalizable driving decisions, are attracting growing attention from both academia and industry. However, once deployed on public roads, ADSs are inevitably exposed to diverse driving hazards that may compromise safety and degrade system performance. This raises a strong demand for resilience of ADSs, particularly the capability to continuously monitor driving hazards and adaptively respond to potential safety violations, which is crucial for maintaining robust driving behaviors in complex driving scenarios. To bridge this gap, we propose a runtime resilience-oriented framework, Argus, to mitigate the driving hazards, thus preventing potential safety violations and improving the driving performance of an ADS. Argus continuously monitors the trajectories generated by the ADS for potential hazards and, whenever the EGO vehicle is deemed unsafe, seamlessly takes control through a hazard mitigator. We integrate Argus with three state-of-the-art end-to-end ADSs, i.e., TCP, UniAD and VAD. Our evaluation has demonstrated that Argus effectively and efficiently enhances the resilience of ADSs, improving the driving score of the ADS by up to 150.30% on average, and preventing up to 64.38% of the violations, with little additional time overhead.

LLMs have achieved remarkable breakthroughs in reasoning, insights, and tool use, but chaining these abilities into extended processes at the scale of those routinely executed by humans, organizations, and societies has remained out of reach. The models have a persistent error rate that prevents scale-up: for instance, recent experiments in the Towers of Hanoi benchmark domain showed that the process inevitably becomes derailed after at most a few hundred steps. Thus, although LLM research is often still benchmarked on tasks with relatively few dependent logical steps, there is increasing attention on the ability (or inability) of LLMs to perform long range tasks. This paper describes MAKER, the first system that successfully solves a task with over one million LLM steps with zero errors, and, in principle, scales far beyond this level. The approach relies on an extreme decomposition of a task into subtasks, each of which can be tackled by focused microagents. The high level of modularity resulting from the decomposition allows error correction to be applied at each step through an efficient multi-agent voting scheme. This combination of extreme decomposition and error correction makes scaling possible. Thus, the results suggest that instead of relying on continual improvement of current LLMs, massively decomposed agentic processes (MDAPs) may provide a way to efficiently solve problems at the level of organizations and societies.

Whole-genome sequencing (WGS) has revealed numerous non-coding short variants whose functional impacts remain poorly understood. Despite recent advances in deep-learning genomic approaches, accurately predicting and prioritizing clinically relevant mutations in gene regulatory regions remains a major challenge. Here we introduce Deep VRegulome, a deep-learning method for prediction and interpretation of functionally disruptive variants in the human regulome, which combines 700 DNABERT fine-tuned models, trained on vast amounts of ENCODE gene regulatory regions, with variant scoring, motif analysis, attention-based visualization, and survival analysis. We showcase its application on TCGA glioblastoma WGS dataset in prioritizing survival-associated mutations and regulatory regions. The analysis identified 572 splice-disrupting and 9,837 transcription-factor binding site altering mutations occurring in greater than 10% of glioblastoma samples. Survival analysis linked 1352 mutations and 563 disrupted regulatory regions to patient outcomes, enabling stratification via non-coding mutation signatures. All the code, fine-tuned models, and an interactive data portal are publicly available.

Large Language Models (LLMs) have impressive data fusion and reasoning capabilities for autonomous driving (AD). However, training LLMs for AD faces significant challenges including high computation transmission costs, and privacy concerns associated with sensitive driving data. Federated Learning (FL) is promising for enabling autonomous vehicles (AVs) to collaboratively train models without sharing raw data. We present Federated LLM-based Autonomous Driving (FLAD), an FL framework that leverages distributed multimodal sensory data across AVs in heterogeneous environment. FLAD has three key innovations: (1) a cloud-edge-vehicle collaborative architecture that reduces communication delay and preserving data privacy; (2) an intelligent parallelized collaborative training with a communication scheduling mechanism that optimizes training efficiency, leveraging end-devices otherwise having insufficient resources for model training; and (3) a knowledge distillation method that personalizes LLM according to heterogeneous edge data. In addition, we prototype FLAD in a testbed with NVIDIA Jetsons, overcoming practical implementation challenges including CPU/GPU memory sharing in resource-constrained devices, dynamic model partitions, and fault-tolerant training.Extensive experimental evaluation demonstrates that FLAD achieves superior end-to-end AD performance while efficiently utilizing distributed vehicular resources, opening up new possibilities for future collaborative AD model training and knowledge sharing.

With the widespread adoption of unmanned aerial vehicles (UAV), effective path planning has become increasingly important. Although traditional search methods have been extensively applied, metaheuristic algorithms have gained popularity due to their efficiency and problem-specific heuristics. However, challenges such as premature convergence and lack of solution diversity still hinder their performance in complex scenarios. To address these issues, this paper proposes an Enhanced Multi-Strategy Dwarf Mongoose Optimization (EDMO) algorithm, tailored for three-dimensional UAV trajectory planning in dynamic and obstacle-rich environments. EDMO integrates three novel strategies: (1) a Dynamic Quantum Tunneling Optimization Strategy (DQTOS) to enable particles to probabilistically escape local optima; (2) a Bio-phototactic Dynamic Focusing Search Strategy (BDFSS) inspired by microbial phototaxis for adaptive local refinement; and (3) an Orthogonal Lens Opposition-Based Learning (OLOBL) strategy to enhance global exploration through structured dimensional recombination. EDMO is benchmarked on 39 standard test functions from CEC2017 and CEC2020, outperforming 14 advanced algorithms in convergence speed, robustness, and optimization accuracy. Furthermore, real-world validations on UAV three-dimensional path planning and three engineering design tasks confirm its practical applicability and effectiveness in field robotics missions requiring intelligent, adaptive, and time-efficient planning.

Autonomous driving holds transformative potential but remains fundamentally constrained by the limited perception and isolated decision-making with standalone intelligence. While recent multi-agent approaches introduce cooperation, they often focus merely on perception-level tasks, overlooking the alignment with downstream planning and control, or fall short in leveraging the full capacity of the recent emerging end-to-end autonomous driving. In this paper, we present UniMM-V2X, a novel end-to-end multi-agent framework that enables hierarchical cooperation across perception, prediction, and planning. At the core of our framework is a multi-level fusion strategy that unifies perception and prediction cooperation, allowing agents to share queries and reason cooperatively for consistent and safe decision-making. To adapt to diverse downstream tasks and further enhance the quality of multi-level fusion, we incorporate a Mixture-of-Experts (MoE) architecture to dynamically enhance the BEV representations. We further extend MoE into the decoder to better capture diverse motion patterns. Extensive experiments on the DAIR-V2X dataset demonstrate our approach achieves state-of-the-art (SOTA) performance with a 39.7% improvement in perception accuracy, a 7.2% reduction in prediction error, and a 33.2% improvement in planning performance compared with UniV2X, showcasing the strength of our MoE-enhanced multi-level cooperative paradigm.

Large Language Models perform well at natural language interpretation and reasoning, but their inherent stochasticity limits their adoption in regulated industries like finance and healthcare that operate under strict policies. To address this limitation, we present a two-stage neurosymbolic framework that (1) uses LLMs with optional human guidance to formalize natural language policies, allowing fine-grained control of the formalization process, and (2) uses inference-time autofor-malization to validate logical correctness of natural language statements against those policies. When correctness is paramount, we perform multiple redundant formalization steps at inference time, cross checking the formalizations for semantic equivalence. Our benchmarks demonstrate that our approach exceeds 99% soundness, indicating a near-zero false positive rate in identifying logical validity. Our approach produces auditable logical artifacts that substantiate the verification outcomes and can be used to improve the original text. The content generation and reasoning capabilities of Large Language Models (LLMs) continue to advance rapidly, demonstrating unprecedented improvements in coherence and analytical accuracy (Wei et al., 2022; Y ao et al., 2023; Lewis et al., 2021). Despite these advances, their probabilistic nature and tendency to generate plausible but incorrect information (hallucinations, cf. Xu et al. 2024b) remain barriers to widespread adoption in regulated sectors. Industries such as healthcare, financial services, and legal practices have legal and regulatory obligations for accuracy and auditability that current LLM technology has yet to meet (Haltaufderheide & Ranisch, 2024). Companies develop institutional policies to ensure compliance with applicable laws and regulations. Such policies are typically captured in natural language (NL) documents that define rules, procedures, or guidelines. A challenge thus emerges when organizations look to deploy LLMs to answer questions about such documents: can we develop guardrails to ensure that LLM outputs conform to institutional policies? Consider an airline implementing a chatbot to assist customer service representatives in navigating refund policies: if the chatbot incorrectly claims that a customer is eligible for a refund when they are not, this could lead to legal exposure and loss of customer trust. An effective guardrail would help representatives decide if they can rely on a chatbot response without spending additional human effort to verify it. The key concern would be to ensure that when the guardrail reports an answer is valid, it actually is.