This paper introduces a structured approach to improving decision making in Decentralized Autonomous Organizations (DAO) through the integration of the Question-Option-Criteria (QOC) model and AI agents. We outline a stepwise governance framework that evolves from human led evaluations to fully autonomous, AI-driven processes. By decomposing decisions into weighted, criterion based evaluations, the QOC model enhances transparency, fairness, and explainability in DAO voting. We demonstrate how large language models (LLMs) and stakeholder aligned AI agents can support or automate evaluations, while statistical safeguards help detect manipulation. The proposed framework lays the foundation for scalable and trustworthy governance in the Web3 ecosystem.

Spatial transcriptomics is an emerging field that enables the identification of functional regions based on the spatial distribution of gene expression. Integrating this functional information present in transcriptomic data with structural data from histopathology images is an active research area with applications in identifying tumor substructures associated with cancer drug resistance. Current histopathology-spatial-transcriptomic region segmentation methods suffer due to either making spatial transcriptomics prominent by using histopathology features just to assist processing spatial transcriptomics data or using vanilla contrastive learning that make histopathology images prominent due to only promoting common features losing functional information. In both extremes, the model gets either lost in the noise of spatial transcriptomics or overly smoothed, losing essential information. Thus, we propose our novel architecture SENCA-st (Shared Encoder with Neighborhood Cross Attention) that preserves the features of both modalities. More importantly, it emphasizes regions that are structurally similar in histopathology but functionally different on spatial transcriptomics using cross-attention. We demonstrate the superior performance of our model that surpasses state-of-the-art methods in detecting tumor heterogeneity and tumor micro-environment regions, a clinically crucial aspect.

The complexity and opacity of neural networks (NNs) pose significant challenges, particularly in high-stakes fields such as healthcare, finance, and law, where understanding decision-making processes is crucial. To address these issues, the field of explainable artificial intelligence (XAI) has developed various methods aimed at clarifying AI decision-making, thereby facilitating appropriate trust and validating the fairness of outcomes. Among these methods, prototype-based explanations offer a promising approach that uses representative examples to elucidate model behavior. However, a critical gap exists regarding standardized benchmarks to objectively compare prototype-based XAI methods, especially in the context of time series data. This lack of reliable benchmarks results in subjective evaluations, hindering progress in the field. We aim to establish a robust framework, ProtoScore, for assessing prototype-based XAI methods across different data types with a focus on time series data, facilitating fair and comprehensive evaluations. By integrating the Co-12 properties of Nauta et al., this framework allows for effectively comparing prototype methods against each other and against other XAI methods, ultimately assisting practitioners in selecting appropriate explanation methods while minimizing the costs associated with user studies. All code is publicly available at https://github.com/HelenaM23/ProtoScore .

Hit identification is a central challenge in early drug discovery, traditionally requiring substantial experimental resources. Recent advances in artificial intelligence, particularly large language models (LLMs), have enabled virtual screening methods that reduce costs and improve efficiency. However, the growing complexity of these tools has limited their accessibility to wet-lab researchers. Multi-agent systems offer a promising solution by combining the interpretability of LLMs with the precision of specialized models and tools. In this work, we present MADD, a multi-agent system that builds and executes customized hit identification pipelines from natural language queries. MADD employs four coordinated agents to handle key subtasks in de novo compound generation and screening. We evaluate MADD across seven drug discovery cases and demonstrate its superior performance compared to existing LLM-based solutions. Using MADD, we pioneer the application of AI-first drug design to five biological targets and release the identified hit molecules. Finally, we introduce a new benchmark of query-molecule pairs and docking scores for over three million compounds to contribute to the agentic future of drug design.

There is an increasing number of virtual communities and forums available on the web. With social media, people can freely communicate and share their thoughts, ask personal questions, and seek peer-support, especially those with conditions that are highly stigmatized, without revealing personal identity. We study the state-of-the-art research methodologies and findings on mental health challenges like depression, anxiety, suicidal thoughts, from the pervasive use of social media data. We also discuss how these novel thinking and approaches can help to raise awareness of mental health issues in an unprecedented way. Specifically, this chapter describes linguistic, visual, and emotional indicators expressed in user disclosures. The main goal of this chapter is to show how this new source of data can be tapped to improve medical practice, provide timely support, and influence government or policymakers. In the context of social media for mental health issues, this chapter categorizes social media data used, introduces different deployed machine learning, feature engineering, natural language processing, and surveys methods and outlines directions for future research.

Abstract--With the rapid advancements in machine learning, models have become increasingly capable of learning and making predictions in various industries. However, deploying these models in critical infrastructures presents a major challenge, as concerns about data privacy prevent unrestricted data sharing. Homomor-phic encryption (HE) offers a solution by enabling computations on encrypted data, but it remains incompatible with machine learning models like convolutional neural networks (CNNs), due to their reliance on non-linear activation functions. T o bridge this gap, this work proposes an optimized framework that replaces standard non-linear functions with homomorphically compatible approximations, ensuring secure computations while minimizing computational overhead. The proposed approach restructures the CNN architecture and introduces an efficient activation function approximation method to mitigate the performance trade-offs introduced by encryption. Experiments on CIF AR-10 achieve 94.4% accuracy with 2.42 s per single encrypted sample and 24,000 s per 10,000 encrypted samples, using a degree-4 polynomial and Softplus activation under CKKS, balancing accuracy and privacy. Neural networks have demonstrated remarkable predictive performance and delivered innovative solutions across a broad spectrum of domains.

Educational dialogue -- the collaborative exchange of ideas through talk -- is widely recognized as a catalyst for deeper learning and critical thinking in and across contexts. At the same time, artificial intelligence (AI) has rapidly emerged as a powerful force in education, with the potential to address major challenges, personalize learning, and innovate teaching practices. However, these advances come with significant risks: rapid AI development can undermine human agency, exacerbate inequities, and outpace our capacity to guide its use with sound policy. Human learning presupposes cognitive efforts and social interaction (dialogues). In response to this evolving landscape, an international workshop titled "Educational Dialogue: Moving Thinking Forward" convened 19 leading researchers from 11 countries in Cambridge (September 1-3, 2025) to examine the intersection of AI and educational dialogue. This AI-focused strand of the workshop centered on three critical questions: (1) When is AI truly useful in education, and when might it merely replace human effort at the expense of learning? (2) Under what conditions can AI use lead to better dialogic teaching and learning? (3) Does the AI-human partnership risk outpacing and displacing human educational work, and what are the implications? These questions framed two days of presentations and structured dialogue among participants.

Fatigue life prediction is essential in both the design and operational phases of any aircraft, and in this sense safety in the aerospace industry requires early detection of fatigue cracks to prevent in-flight failures. Robust and precise fatigue life predictors are thus essential to ensure safety. Traditional engineering methods, while reliable, are time consuming and involve complex workflows, including steps such as conducting several Finite Element Method (FEM) simulations, deriving the expected loading spectrum, and applying cycle counting techniques like peak-valley or rainflow counting. These steps often require collaboration between multiple teams and tools, added to the computational time and effort required to achieve fatigue life predictions. Machine learning (ML) offers a promising complement to traditional fatigue life estimation methods, enabling faster iterations and generalization, providing quick estimates that guide decisions alongside conventional simulations. In this paper, we present a ML-based pipeline that aims to estimate the fatigue life of different aircraft wing locations given the flight parameters of the different missions that the aircraft will be operating throughout its operational life. We validate the pipeline in a realistic use case of fatigue life estimation, yielding accurate predictions alongside a thorough statistical validation and uncertainty quantification. Our pipeline constitutes a complement to traditional methodologies by reducing the amount of costly simulations and, thereby, lowering the required computational and human resources.

This paper examines the ethical and anthropological challenges posed by AI-driven recommender systems (RSs), which increasingly shape digital environments and social interactions. By curating personalized content, RSs do not merely reflect user preferences but actively construct experiences across social media, entertainment platforms, and e-commerce. Their influence raises concerns over privacy, autonomy, and mental well-being, while existing approaches such as "algorethics" - the effort to embed ethical principles into algorithmic design - remain insufficient. RSs inherently reduce human complexity to quantifiable profiles, exploit user vulnerabilities, and prioritize engagement over well-being. The paper advances a three-dimensional framework for human-centered RSs, integrating policies and regulation, interdisciplinary research, and education. These strategies are mutually reinforcing: research provides evidence for policy, policy enables safeguards and standards, and education equips users to engage critically. By connecting ethical reflection with governance and digital literacy, the paper argues that RSs can be reoriented to enhance autonomy and dignity rather than undermine them.

Military weapon systems and command-and-control infrastructure augmented by artificial intelligence (AI) have seen rapid development and deployment in recent years. However, the sociotechnical impacts of AI on combat systems, military decision-making, and the norms of warfare have been understudied. We focus on a specific subset of lethal autonomous weapon systems (LAWS) that use AI for targeting or battlefield decisions. We refer to this subset as AI-powered lethal autonomous weapon systems (AI-LAWS) and argue that they introduce novel risks -- including unanticipated escalation, poor reliability in unfamiliar environments, and erosion of human oversight -- all of which threaten both military effectiveness and the openness of AI research. These risks cannot be addressed by high-level policy alone; effective regulation must be grounded in the technical behavior of AI models. We argue that AI researchers must be involved throughout the regulatory lifecycle. Thus, we propose a clear, behavior-based definition of AI-LAWS -- systems that introduce unique risks through their use of modern AI -- as a foundation for technically grounded regulation, given that existing frameworks do not distinguish them from conventional LAWS. Using this definition, we propose several technically-informed policy directions and invite greater participation from the AI research community in military AI policy discussions.