The risk of indoor airborne transmission among co-located individuals is generally non-uniform, which remains a critical challenge for public health modelling. Thus, we present CompARE, an integrated risk assessment framework for indoor airborne disease transmission that reveals a striking bimodal distribution of infection risk driven by airflow dynamics and human behavior. Combining computational fluid dynamics (CFD), machine learning (ML), and agent-based modeling (ABM), our model captures the complex interplay between aerosol transport, human mobility, and environmental context. Based on a prototypical childcare center, our approach quantifies how incorporation of ABM can unveil significantly different infection risk profiles across agents, with more than two-fold change in risk of infection between the individuals with the lowest and highest risks in more than 90% of cases, despite all individuals being in the same overall environment. We found that infection risk distributions can exhibit not only a striking bimodal pattern in certain activities but also exponential decay and fat-tailed behavior in others. Specifically, we identify low-risk modes arising from source containment, as well as high-risk tails from prolonged close contact. Our approach enables near-real-time scenario analysis and provides policy-relevant quantitative insights into how ventilation design, spatial layout, and social distancing policies can mitigate transmission risk. These findings challenge simple distance-based heuristics and support the design of targeted, evidence-based interventions in high-occupancy indoor settings.

The Ribonucleic Acid (RNA) inverse folding problem, designing nucleotide sequences that fold into specific tertiary structures, is a fundamental computational biology problem with important applications in synthetic biology and bioengineering. The design of complex three-dimensional RNA architectures remains computationally demanding and mostly unresolved, as most existing approaches focus on secondary structures. In order to address tertiary RNA inverse folding, we present BeeRNA, a bio-inspired method that employs the Artificial Bee Colony (ABC) optimization algorithm. Our approach combines base-pair distance filtering with RMSD-based structural assessment using RhoFold for structure prediction, resulting in a two-stage fitness evaluation strategy. To guarantee biologically plausible sequences with balanced GC content, the algorithm takes thermodynamic constraints and adaptive mutation rates into consideration. In this work, we focus primarily on short and medium-length RNAs ($<$ 100 nucleotides), a biologically significant regime that includes microRNAs (miRNAs), aptamers, and ribozymes, where BeeRNA achieves high structural fidelity with practical CPU runtimes. The lightweight, training-free implementation will be publicly released for reproducibility, offering a promising bio-inspired approach for RNA design in therapeutics and biotechnology.

Myofascial pain (MP) is a leading cause of chronic low back pain, yet its tissue-level drivers remain poorly defined and lack reliable image biomarkers. Existing studies focus predominantly on muscle while neglecting fascia, fat, and other soft tissues that play integral biomechanical roles. We developed an anatomically grounded explainable artificial intelligence (AI) framework, LAYER (Layer-wise Analysis for Yielding Explainable Relevance Tissue), that analyses six tissue layers in three-dimensional (3D) ultrasound and quantifies their contribution to MP prediction. By utilizing the largest multi-model 3D ultrasound cohort consisting of over 4,000 scans, LAYER reveals that non-muscle tissues contribute substantially to pain prediction. In B-mode imaging, the deep fascial membrane (DFM) showed the highest saliency (0.420), while in combined B-mode and shear-wave images, the collective saliency of non-muscle layers (0.316) nearly matches that of muscle (0.317), challenging the conventional muscle-centric paradigm in MP research and potentially affecting the therapy methods. LAYER establishes a quantitative, interpretable framework for linking layer-specific anatomy to pain physiology, uncovering new tissue targets and providing a generalizable approach for explainable analysis of soft-tissue imaging.

Large language model (LLM) services have been rapidly integrated into people's daily lives as chatbots and agentic systems. They are nourished by collecting rich streams of data, raising privacy concerns around excessive collection of sensitive personal information. Privacy policies are the fundamental mechanism for informing users about data practices in modern information privacy paradigm. Although traditional web and mobile policies are well studied, the privacy policies of LLM providers, their LLM-specific content, and their evolution over time remain largely underexplored. In this paper, we present the first longitudinal empirical study of privacy policies for mainstream LLM providers worldwide. We curate a chronological dataset of 74 historical privacy policies and 115 supplemental privacy documents from 11 LLM providers across 5 countries up to August 2025, and extract over 3,000 sentence-level edits between consecutive policy versions. We compare LLM privacy policies to those of other software formats, propose a taxonomy tailored to LLM privacy policies, annotate policy edits and align them with a timeline of key LLM ecosystem events. Results show they are substantially longer, demand college-level reading ability, and remain highly vague. Our taxonomy analysis reveals patterns in how providers disclose LLM-specific practices and highlights regional disparities in coverage. Policy edits are concentrated in first-party data collection and international/specific-audience sections, and that product releases and regulatory actions are the primary drivers, shedding light on the status quo and the evolution of LLM privacy policies.

The integration of Large Language Models (LLMs) into healthcare demands a safety paradigm rooted in \textit{primum non nocere}. However, current alignment techniques rely on generic definitions of harm that fail to capture context-dependent violations, such as administrative fraud and clinical discrimination. To address this, we introduce Medical Malice: a dataset of 214,219 adversarial prompts calibrated to the regulatory and ethical complexities of the Brazilian Unified Health System (SUS). Crucially, the dataset includes the reasoning behind each violation, enabling models to internalize ethical boundaries rather than merely memorizing a fixed set of refusals. Using an unaligned agent (Grok-4) within a persona-driven pipeline, we synthesized high-fidelity threats across seven taxonomies, ranging from procurement manipulation and queue-jumping to obstetric violence. We discuss the ethical design of releasing these "vulnerability signatures" to correct the information asymmetry between malicious actors and AI developers. Ultimately, this work advocates for a shift from universal to context-aware safety, providing the necessary resources to immunize healthcare AI against the nuanced, systemic threats inherent to high-stakes medical environments -- vulnerabilities that represent the paramount risk to patient safety and the successful integration of AI in healthcare systems.

Large Language Models (LLMs) are increasingly deployed in high-stakes financial domains, yet they suffer from specific, reproducible hallucinations when performing arithmetic operations. Current mitigation strategies often treat the model as a black box. In this work, we propose a mechanistic approach to intrinsic hallucination detection. By applying Causal Tracing to the GPT-2 XL architecture on the ConvFinQA benchmark, we identify a dual-stage mechanism for arithmetic reasoning: a distributed computational scratchpad in middle layers (L12-L30) and a decisive aggregation circuit in late layers (specifically Layer 46). We verify this mechanism via an ablation study, demonstrating that suppressing Layer 46 reduces the model's confidence in hallucinatory outputs by 81.8%. Furthermore, we demonstrate that a linear probe trained on this layer generalizes to unseen financial topics with 98% accuracy, suggesting a universal geometry of arithmetic deception.

Large-scale disasters can often result in catastrophic consequences on people and infrastructure. Situation awareness about such disaster impacts generated by authoritative data from in-situ sensors, remote sensing imagery, and/or geographic data is often limited due to atmospheric opacity, satellite revisits, and time limitations. This often results in geo-temporal information gaps. In contrast, impact-related social media posts can act as "geo-sensors" during a disaster, where people describe specific impacts and locations. However, not all locations mentioned in disaster-related social media posts relate to an impact. Only the impacted locations are critical for directing resources effectively. e.g., "The death toll from a fire which ripped through the Greek coastal town of #Mati stood at 80, with dozens of people unaccounted for as forensic experts tried to identify victims who were burned alive #Greecefires #AthensFires #Athens #Greece." contains impacted location "Mati" and non-impacted locations "Greece" and "Athens". This research uses Large Language Models (LLMs) to identify all locations, impacts and impacted locations mentioned in disaster-related social media posts. In the process, LLMs are fine-tuned to identify only impacts and impacted locations (as distinct from other, non-impacted locations), including locations mentioned in informal expressions, abbreviations, and short forms. Our fine-tuned model demonstrates efficacy, achieving an F1-score of 0.69 for impact and 0.74 for impacted location extraction, substantially outperforming the pre-trained baseline. These robust results confirm the potential of fine-tuned language models to offer a scalable solution for timely decision-making in resource allocation, situational awareness, and post-disaster recovery planning for responders.

The discovery of next-generation photoinitiators for two-photon polymerization (TPP) is hindered by the absence of large, open datasets containing the quantum-chemical and photophysical properties required to model photodissociation and excited-state behavior. Existing molecular datasets typically provide only basic physicochemical descriptors and therefore cannot support data-driven screening or AI-assisted design of photoinitiators. To address this gap, we introduce QuantumChem-200K, a large-scale dataset of over 200,000 organic molecules annotated with eleven quantum-chemical properties, including two-photon absorption (TPA) cross sections, TPA spectral ranges, singlet-triplet intersystem crossing (ISC) energies, toxicity and synthetic accessibility scores, hydrophilicity, solubility, boiling point, molecular weight, and aromaticity. These values are computed using a hybrid workflow that integrates density function theory (DFT), semi-empirical excited-state methods, atomistic quantum solvers, and neural-network predictors. Using QuantumChem-200K, we fine tune the open-source Qwen2.5-32B large language model to create a chemistry AI assistant capable of forward property prediction from SMILES. Benchmarking on 3000 unseen molecules from VQM24 and ZINC20 demonstrates that domain-specific fine-tuning significantly improves accuracy over GPT-4o, Llama-3.1-70B, and the base Qwen2.5-32B model, particularly for TPA and ISC predictions central to photoinitiator design. QuantumChem-200K and the corresponding AI assistant together provide the first scalable platform for high-throughput, LLM-driven photoinitiator screening and accelerated discovery of photosensitive materials.

Electroencephalogram (EEG)-to-text remains challenging due to high-dimensional noise, subject variability, and error accumulation in autoregressive decoding. We introduce DELTA, which pairs a Residual Vector Quantization (RVQ) EEG tokenizer with a masked language diffusion model (LLaDA). RVQ discretizes continuous EEG into multi-layer tokens to reduce noise and individual differences, while LLaDA reconstructs sentences via non-sequential denoising. On ZuCo, DELTA improves semantic alignment by up to 5.37 points over autoregressive baselines, achieving BLEU-1 21.9 and ROUGE-1 F 17.2 under word-level conditions. These results enable reliable text generation from small EEG-text datasets and point toward scalable multimodal EEG-language models.

With the growing use of Large Language Model (LLM)- based Question-Answering (QA) systems in education, it is critical to evaluate their performance across individual pipeline components. In this work, we introduce EduMod-LLM, a modular function-calling LLM pipeline, and present a comprehensive evaluation along three key axes: function calling strategies, retrieval methods, and generative language models. Our framework enables fine-grained analysis by isolating and assessing each component. We benchmark function-calling performance across LLMs, compare our novel structure-aware retrieval method to vector-based and LLM-scoring baselines, and evaluate various LLMs for response synthesis. This modular approach reveals specific failure modes and performance patterns, supporting the development of interpretable and effective educational QA systems. Our findings demonstrate the value of modular function calling in improving system transparency and pedagogical alignment.