Chronic Kidney Disease (CKD) constitutes a major global medical burden, marked by the gradual deterioration of renal function, which results in the impaired clearance of metabolic waste and disturbances in systemic fluid homeostasis. Owing to its substantial contribution to worldwide morbidity and mortality, the development of reliable and efficient diagnostic approaches is critically important to facilitate early detection and prompt clinical management. This study presents a deep convolutional neural network (CNN) for early CKD detection from CT kidney images, complemented by class balancing using Synthetic Minority Over-sampling Technique (SMOTE) and interpretability via Gradient-weighted Class Activation Mapping (Grad-CAM). The model was trained and evaluated on the CT KIDNEY DATASET, which contains 12,446 CT images, including 3,709 cyst, 5,077 normal, 1,377 stone, and 2,283 tumor cases. The proposed deep CNN achieved a remarkable classification performance, attaining 100% accuracy in the early detection of chronic kidney disease (CKD). This significant advancement demonstrates strong potential for addressing critical clinical diagnostic challenges and enhancing early medical intervention strategies.

We present a novel multi-stage workflow for computational materials discovery that achieves a 99% success rate in identifying compounds within 100 meV/atom of thermodynamic stability, with a threefold improvement over previous approaches. By combining the Matra-Genoa generative model, Orb-v2 universal machine learning interatomic potential, and ALIGNN graph neural network for energy prediction, we generated 119 million candidate structures and added 1.3 million DFT-validated compounds to the ALEXANDRIA database, including 74 thousand new stable materials. The expanded ALEXANDRIA database now contains 5.8 million structures with 175 thousand compounds on the convex hull. Predicted structural disorder rates (37-43%) match experimental databases, unlike other recent AI-generated datasets. Analysis reveals fundamental patterns in space group distributions, coordination environments, and phase stability networks, including sub-linear scaling of convex hull connectivity. We release the complete dataset, including sAlex25 with 14 million out-of-equilibrium structures containing forces and stresses for training universal force fields. We demonstrate that fine-tuning a GRACE model on this data improves benchmark accuracy. All data, models, and workflows are freely available under Creative Commons licenses.

Narratives about artificial intelligence (AI) entangle autonomy, the capacity to self-govern, with sentience, the capacity to sense and feel. AI agents that perform tasks autonomously and companions that recognize and express emotions may activate mental models of autonomy and sentience, respectively, provoking distinct reactions. To examine this possibility, we conducted three pilot studies (N = 374) and four preregistered vignette experiments describing an AI as autonomous, sentient, both, or neither (N = 2,702). Activating a mental model of sentience increased general mind perception (cognition and emotion) and moral consideration more than autonomy, but autonomy increased perceived threat more than sentience. Sentience also increased perceived autonomy more than vice versa. Based on a within-paper meta-analysis, sentience changed reactions more than autonomy on average. By disentangling different mental models of AI, we can study human-AI interaction with more precision to better navigate the detailed design of anthropomorphized AI and prompting interfaces.

Severe heatwaves in urban areas significantly threaten public health, calling for establishing early warning strategies. Despite predicting occurrence of heatwaves and attributing historical mortality, predicting an incoming deadly heatwave remains a challenge due to the difficulty in defining and estimating heat-related mortality. Furthermore, establishing an early warning system imposes additional requirements, including data availability, spatial and temporal robustness, and decision costs. To address these challenges, we propose DeepTherm, a modular early warning system for deadly heatwave prediction without requiring heat-related mortality history. By highlighting the flexibility of deep learning, DeepTherm employs a dual-prediction pipeline, disentangling baseline mortality in the absence of heatwaves and other irregular events from all-cause mortality. We evaluated DeepTherm on real-world data across Spain. Results demonstrate consistent, robust, and accurate performance across diverse regions, time periods, and population groups while allowing trade-off between missed alarms and false alarms.

Neural networks, while effective for tackling many challengi ng scientific tasks, are not known to perform well out-of-distribution (OOD), i.e., within domains which d iffer from their training data. Understanding neural network OOD generalization is paramount to their suc cessful deployment in experimental workflows, especially when ground-truth knowledge about the experime nt is hard to establish or experimental conditions significantly vary. With inherent access to ground-truth in formation and fine-grained control of underlying distributions, simulation-based data curation facilitate s precise investigation of OOD generalization behavior. Here, we probe generalization with respect to imaging condi tions of neural network segmentation models for high-resolution transmission electron microscopy (HRTEM) imaging of nanoparticles, training and measuring the OOD generalization of over 12,000 neural networks using synthetic data generated via random structure sampling and multislice simulation. Using the HRTEM contra st transfer function, we further develop a framework to compare information content of HRTEM datasets an d quantify OOD domain shifts. We demonstrate that neural network segmentation models enjoy significant performance stability, but will smoothly and predictably worsen as imaging conditions shift from the training distribution. Lastly, we consider limitations of our approach in explaining other OOD shifts, s uch as of the atomic structures, and discuss complementary techniques for understanding generalizatio n in such settings.

Accurate precipitation forecasting is essential for hydrometeorological risk management, especially for anticipating extreme rainfall that can lead to flash flooding and infrastructure damage. This study introduces a diffusion-based deep learning (DL) framework that systematically compares three residual prediction strategies differing only in their input sources: (1) a fully data-driven model using only past observations from the Multi-Radar Multi-Sensor (MRMS) system, (2) a corrective model using only forecasts from the High-Resolution Rapid Refresh (HRRR) numerical weather prediction system, and (3) a hybrid model integrating both MRMS and selected HRRR forecast variables. By evaluating these approaches under a unified setup, we provide a clearer understanding of how each data source contributes to predictive skill over the Continental United States (CONUS). Forecasts are produced at 1-km spatial resolution, beginning with direct 1-hour predictions and extending to 12 hours using autoregressive rollouts. Performance is evaluated using both CONUS-wide and region-specific metrics that assess overall performance and skill at extreme rainfall thresholds. Across all lead times, our DL framework consistently outperforms the HRRR baseline in pixel-wise and spatiostatistical metrics. The hybrid model performs best at the shortest lead time, while the HRRR-corrective model outperforms others at longer lead times, maintaining high skill through 12 hours. To assess reliability, we incorporate calibrated uncertainty quantification tailored to the residual learning setup. These gains, particularly at longer lead times, are critical for emergency preparedness, where modest increases in forecast horizon can improve decision-making. This work advances DL-based precipitation forecasting by enhancing predictive skill, reliability, and applicability across regions.

Face recognition (FR) systems are often prone to demographic biases, partially due to the entanglement of demographic-specific information with identity-relevant features in facial embeddings. This bias is extremely critical in large multicultural cities, especially where biometrics play a major role in smart city infrastructure. The entanglement can cause demographic attributes to overshadow identity cues in the embedding space, resulting in disparities in verification performance across different demographic groups. To address this issue, we propose a novel strategy, Unified Text-Image Embedding (UTIE), which aims to induce demographic ambiguity in face embeddings by enriching them with information related to other demographic groups. This encourages face embeddings to emphasize identity-relevant features and thus promotes fairer verification performance across groups. UTIE leverages the zero-shot capabilities and cross-modal semantic alignment of Vision-Language Models (VLMs). Given that VLMs are naturally trained to align visual and textual representations, we enrich the facial embeddings of each demographic group with text-derived demographic features extracted from other demographic groups. This encourages a more neutral representation in terms of demographic attributes. We evaluate UTIE using three VLMs, CLIP, OpenCLIP, and SigLIP, on two widely used benchmarks, RFW and BFW, designed to assess bias in FR. Experimental results show that UTIE consistently reduces bias metrics while maintaining, or even improving in several cases, the face verification accuracy.

To counter fragmented, high-risk adoption of commercial AI tools, we built and ran an institutional AI platform in a six-month, 300-user pilot, showing that a university of applied sciences can offer advanced AI with fair access, transparent risks, controlled costs, and alignment with European law. Commercial AI subscriptions create unequal access and compliance risks through opaque processing and non-EU hosting, yet banning them is neither realistic nor useful. Institutions need a way to provide powerful AI in a sovereign, accountable form. Our solution is a governed gateway platform with three layers: a ChatGPT-style frontend linked to institutional identity that makes model choice explicit; a gateway core enforcing policy, controlling access and budgets, and routing traffic to EU infrastructure by default; and a provider layer wrapping commercial and open-source models in institutional model cards that consolidate vendor documentation into one governance interface. The pilot ran reliably with no privacy incidents and strong adoption, enabling EU-default routing, managed spending, and transparent model choices. Only the gateway pattern combines model diversity and rapid innovation with institutional control. The central insight: AI is not a support function but strategy, demanding dedicated leadership. Sustainable operation requires governance beyond traditional boundaries. We recommend establishing a formal AI Officer role combining technical literacy, governance authority, and educational responsibility. Without it, AI decisions stay ad-hoc and institutional exposure grows. With it, higher-education institutions can realistically operate their own multi-provider AI platform, provided they govern AI as seriously as they teach it.

We propose the Uncertainty Contrastive Framework (UCF), a Positive-Unlabeled (PU) representation learning framework that integrates uncertainty-aware contrastive loss, adaptive temperature scaling, and a self-attention-guided LSTM encoder to improve classification under noisy and imbalanced conditions. UCF dynamically adjusts contrastive weighting based on sample confidence, stabilizes training using positive anchors, and adapts temperature parameters to batch-level variability. Applied to malicious content classification, UCF-generated embeddings enable multiple traditional classifiers to achieve more than 93.38% accuracy, precision above 0.93, and near-perfect recall, with minimal false negatives and competitive ROC-AUC scores. Visual analyses confirm clear separation between positive and unlabeled instances, highlighting the framework's ability to produce calibrated, discriminative embeddings. These results position UCF as a robust and scalable solution for PU learning in high-stakes domains such as cybersecurity and biomedical text mining.

Recent advancements in Large Language Models (LLMs) have led to their widespread adoption in daily applications. Despite their impressive capabilities, they remain vulnerable to adversarial attacks, as even minor meaning-preserving changes such as synonym substitutions can lead to incorrect predictions. As a result, certifying the robustness of LLMs against such adversarial prompts is of vital importance. Existing approaches focused on word deletion or simple denoising strategies to achieve robustness certification. However, these methods face two critical limitations: (1) they yield loose robustness bounds due to the lack of semantic validation for perturbed outputs and (2) they suffer from high computational costs due to repeated sampling. To address these limitations, we propose CluCERT, a novel framework for certifying LLM robustness via clustering-guided denoising smoothing. Specifically, to achieve tighter certified bounds, we introduce a semantic clustering filter that reduces noisy samples and retains meaningful perturbations, supported by theoretical analysis. Furthermore, we enhance computational efficiency through two mechanisms: a refine module that extracts core semantics, and a fast synonym substitution strategy that accelerates the denoising process. Finally, we conduct extensive experiments on various downstream tasks and jailbreak defense scenarios. Experimental results demonstrate that our method outperforms existing certified approaches in both robustness bounds and computational efficiency.