Recent advancements in artificial intelligence have enabled processing of larger inputs, leading everyday software developers to increasingly rely on chat-based large language models (LLMs) like GPT-3.5 and GPT-4 to detect vulnerabilities across entire files, not just within functions. This new development practice requires researchers to urgently investigate whether commonly used LLMs can effectively analyze large file-sized inputs, in order to provide timely insights for software developers and engineers about the pros and cons of this emerging technological trend. Hence, the goal of this paper is to evaluate the effectiveness of several state-of-the-art chat-based LLMs, including the GPT models, in detecting in-file vulnerabilities. We conducted a costly investigation into how the performance of LLMs varies based on vulnerability type, input size, and vulnerability location within the file. To give enough statistical power to our study, we could only focus on the three most common (as well as dangerous) vulnerabilities: XSS, SQL injection, and path traversal. Our findings indicate that the effectiveness of LLMs in detecting these vulnerabilities is strongly influenced by both the location of the vulnerability and the overall size of the input. Specifically, regardless of the vulnerability type, LLMs tend to significantly (p < .05) underperform when detecting vulnerabilities located toward the end of larger files, a pattern we call the 'lost-in-the-end' effect. Finally, to further support software developers and practitioners, we also explored the optimal input size for these LLMs and presented a simple strategy for identifying it, which can be applied to other models and vulnerability types. Eventually, we show how adjusting the input size can lead to significant improvements in LLM-based vulnerability detection, with an average recall increase of over 37% across all models.

Real-world time series often have multiple frequency components that are intertwined with each other, making accurate time series forecasting challenging. Decomposing the mixed frequency components into multiple single frequency components is a natural choice. However, the information density of patterns varies across different frequencies, and employing a uniform modeling approach for different frequency components can lead to inaccurate characterization. To address this challenges, inspired by the flexibility of the recent Kolmogorov-Arnold Network (KAN), we propose a KAN-based Frequency Decomposition Learning architecture (TimeKAN) to address the complex forecasting challenges caused by multiple frequency mixtures. Specifically, TimeKAN mainly consists of three components: Cascaded Frequency Decomposition (CFD) blocks, Multi-order KAN Representation Learning (M-KAN) blocks and Frequency Mixing blocks. CFD blocks adopt a bottom-up cascading approach to obtain series representations for each frequency band. Benefiting from the high flexibility of KAN, we design a novel M-KAN block to learn and represent specific temporal patterns within each frequency band. Finally, Frequency Mixing blocks is used to recombine the frequency bands into the original format. Extensive experimental results across multiple real-world time series datasets demonstrate that TimeKAN achieves state-ofthe-art performance as an extremely lightweight architecture. Time series forecasting (TSF) has garnered significant interest due to its wide range of applications, including finance (Huang et al., 2024), energy management (Yin et al., 2023), traffic flow planning (Jiang & Luo, 2022), and weather forecasting (Lam et al., 2023).

The increasing volume of drug combinations in modern therapeutic regimens needs reliable methods for predicting drug-drug interactions (DDIs). While Large Language Models (LLMs) have revolutionized various domains, their potential in pharmaceutical research, particularly in DDI prediction, remains largely unexplored. This study thoroughly investigates LLMs' capabilities in predicting DDIs by uniquely processing molecular structures (SMILES), target organisms, and gene interaction data as raw text input from the latest DrugBank dataset. We evaluated 18 different LLMs, including proprietary models (GPT-4, Claude, Gemini) and open-source variants (from 1.5B to 72B parameters), first assessing their zero-shot capabilities in DDI prediction. We then fine-tuned selected models (GPT-4, Phi-3.5 2.7B, Qwen-2.5 3B, Gemma-2 9B, and Deepseek R1 distilled Qwen 1.5B) to optimize their performance. Our comprehensive evaluation framework included validation across 13 external DDI datasets, comparing against traditional approaches such as l2-regularized logistic regression. Fine-tuned LLMs demonstrated superior performance, with Phi-3.5 2.7B achieving a sensitivity of 0.978 in DDI prediction, with an accuracy of 0.919 on balanced datasets (50% positive, 50% negative cases). This result represents an improvement over both zero-shot predictions and state-of-the-art machine-learning methods used for DDI prediction. Our analysis reveals that LLMs can effectively capture complex molecular interaction patterns and cases where drug pairs target common genes, making them valuable tools for practical applications in pharmaceutical research and clinical settings.

Understanding temporal dynamics is critical for conversational agents, enabling effective content analysis and informed decision-making. However, time-aware datasets, particularly for persona-grounded conversations, are still limited, which narrows their scope and diminishes their complexity. To address this gap, we introduce MTPChat, a multimodal, time-aware persona dialogue dataset that integrates linguistic, visual, and temporal elements within dialogue and persona memory. Leveraging MTPChat, we propose two time-sensitive tasks: Temporal Next Response Prediction (TNRP) and Temporal Grounding Memory Prediction (TGMP), both designed to assess a model's ability to understand implicit temporal cues and dynamic interactions. Additionally, we present an innovative framework featuring an adaptive temporal module to effectively integrate multimodal streams and capture temporal dependencies. Experimental results validate the challenges posed by MTPChat and demonstrate the effectiveness of our framework in multimodal time-sensitive scenarios.

Multi-source multi-hop question answering (QA) represents a challenging task in natural language processing due to the need for dynamic integration of heterogeneous knowledge sources and multi-step reasoning. Existing methods often suffer from cascading errors, insufficient handling of knowledge conflicts, and computational inefficiency. In this paper, we propose Adaptive Multi-source Knowledge-Oriented Reasoning (AMKOR), a generative framework that leverages large language models (LLMs) to dynamically fuse parametric and retrieved knowledge while exploring reasoning trajectories using probabilistic beam reasoning. AMKOR is further enhanced by a multi-granular learning strategy, optimizing both local reasoning steps and global answer accuracy. Experiments conducted on four widely-used multi-hop QA datasets, including HotpotQA and MuSiQue, demonstrate that AMKOR achieves state-of-the-art performance, significantly outperforming baseline methods on both reasoning accuracy and robustness. Additional analyses confirm its scalability, adaptability to noisy knowledge, and superior ability to handle complex multi-hop tasks. This work establishes a new benchmark for multi-source multi-hop QA by effectively combining reasoning quality and efficiency.

This paper introduces the Large Memory Model (LM2), a decoder-only Transformer architecture enhanced with an auxiliary memory module that aims to address the limitations of standard Transformers in multi-step reasoning, relational argumentation, and synthesizing information distributed over long contexts. The proposed LM2 incorporates a memory module that acts as a contextual representation repository, interacting with input tokens via cross attention and updating through gating mechanisms. To preserve the Transformers general-purpose capabilities, LM2 maintains the original information flow while integrating a complementary memory pathway. Experimental results on the BABILong benchmark demonstrate that the LM2model outperforms both the memory-augmented RMT model by 37.1% and the baseline Llama-3.2 model by 86.3% on average across tasks. LM2 exhibits exceptional capabilities in multi-hop inference, numerical reasoning, and large-context question-answering. On the MMLU dataset, it achieves a 5.0% improvement over a pre-trained vanilla model, demonstrating that its memory module does not degrade performance on general tasks. Further, in our analysis, we explore the memory interpretability, effectiveness of memory modules, and test-time behavior. Our findings emphasize the importance of explicit memory in enhancing Transformer architectures.

Generative Adversarial Networks (GAN) have greatly influenced the development of computer vision and artificial intelligence in the past decade and also connected art and machine intelligence together. This book begins with a detailed introduction to the fundamental principles and historical development of GANs, contrasting them with traditional generative models and elucidating the core adversarial mechanisms through illustrative Python examples. The text systematically addresses the mathematical and theoretical underpinnings including probability theory, statistics, and game theory providing a solid framework for understanding the objectives, loss functions, and optimisation challenges inherent to GAN training. Subsequent chapters review classic variants such as Conditional GANs, DCGANs, InfoGAN, and LAPGAN before progressing to advanced training methodologies like Wasserstein GANs, GANs with gradient penalty, least squares GANs, and spectral normalisation techniques. The book further examines architectural enhancements and task-specific adaptations in generators and discriminators, showcasing practical implementations in high resolution image generation, artistic style transfer, video synthesis, text to image generation and other multimedia applications. The concluding sections offer insights into emerging research trends, including self-attention mechanisms, transformer-based generative models, and a comparative analysis with diffusion models, thus charting promising directions for future developments in both academic and applied settings.

African American English (AAE) presents unique challenges in natural language processing (NLP). This research systematically compares the performance of available NLP models--rule-based, transformer-based, and large language models (LLMs)--capable of identifying key grammatical features of AAE, namely Habitual Be and Multiple Negation. These features were selected for their distinct grammatical complexity and frequency of occurrence. The evaluation involved sentence-level binary classification tasks, using both zero-shot and few-shot strategies. The analysis reveals that while LLMs show promise compared to the baseline, they are influenced by biases such as recency and unrelated features in the text such as formality. This study highlights the necessity for improved model training and architectural adjustments to better accommodate AAE's unique linguistic characteristics. Data and code are available.

The advent of social media has transformed communication, enabling individuals to share their experiences, seek support, and participate in diverse discussions. While extensive research has focused on identifying harmful content like hate speech, the recognition and promotion of positive and supportive interactions remain largely unexplored. This study proposes an innovative approach to detecting online social support in Spanish-language social media texts. We introduce the first annotated dataset specifically created for this task, comprising 3,189 YouTube comments classified as supportive or non-supportive. To address data imbalance, we employed GPT-4o to generate paraphrased comments and create a balanced dataset. We then evaluated social support classification using traditional machine learning models, deep learning architectures, and transformer-based models, including GPT-4o, but only on the unbalanced dataset. Subsequently, we utilized a transformer model to compare the performance between the balanced and unbalanced datasets. Our findings indicate that the balanced dataset yielded improved results for Task 2 (Individual and Group) and Task 3 (Nation, Other, LGBTQ, Black Community, Women, Religion), whereas GPT-4o performed best for Task 1 (Social Support and Non-Support). This study highlights the significance of fostering a supportive online environment and lays the groundwork for future research in automated social support detection.

The development of artificial intelligence (AI) techniques has brought revolutionary changes across various realms. In particular, the use of AI-assisted methods to accelerate chemical research has become a popular and rapidly growing trend, leading to numerous groundbreaking works. In this paper, we provide a comprehensive review of current AI techniques in chemistry from a computational perspective, considering various aspects in the design of methods. We begin by discussing the characteristics of data from diverse sources, followed by an overview of various representation methods. Next, we review existing models for several topical tasks in the field, and conclude by highlighting some key challenges that warrant further attention.