Large-scale population-level datasets, such as the UK Biobank and the All of Us Research Program, often lack covariates needed for a specific analysis, such as genetic or lifestyle measures, while related studies measure them. This creates a cross-population missing data problem in which covariates are completely unobserved in the target population, rather than partially missing within one dataset. We propose an augmented transfer regression learning method for this setting. The key identifying condition is a sub-population shift assumption: the joint distribution of the outcome and observed covariates may differ across source and target populations, but the conditional distribution of the missing covariates given observed variables is invariant. We combine importance-weighted estimating equations with imputation terms for first- and second-order moments of the missing covariates. The resulting estimator is doubly robust, remaining consistent if either the density ratio model or both imputation models are correctly specified. It is $n^{1/2}$-consistent and asymptotically normal, and attains the semiparametric efficiency bound when both nuisance models are correctly specified.

Data-driven decision making frequently relies on predicting counterfactual outcomes. In practice, researchers commonly train counterfactual prediction models on a source dataset to inform decisions on a possibly separate target population. Conformal prediction has arisen as a popular method for producing assumption-lean prediction intervals for counterfactual outcomes that would arise under different treatment decisions in the target population of interest. However, existing methods require that every confounding factor of the treatment-outcome relationship used for training on the source data is additionally measured in the target population, risking miscoverage if important confounders are unmeasured in the target population. In this paper, we introduce a computationally efficient debiased machine learning framework that allows for valid prediction intervals when only a subset of confounders is measured in the target population, a common challenge referred to as runtime confounding. Grounded in semiparametric efficiency theory, we show the resulting prediction intervals achieve desired coverage rates with faster convergence compared to standard methods. Through numerous synthetic and semi-synthetic experiments, we demonstrate the utility of our proposed method.

We aim at using a large observational sample and a possibly much smaller experimental sample.

To address this issue, we propose a novel Covariate Shift Corrected Pearson Chi-squared Conditional Randomization (csPCR) test.

Randomized trials are widely considered as the gold standard for evaluating the effects of decision policies.

To address this issue, we propose a novel Covariate Shift Corrected Pearson Chi-squared Conditional Randomization (csPCR) test.

Agent-based models used in scenario planning for transportation and urban planning usually require detailed population information from the base as well as target scenarios. These populations are usually provided by synthesizing fake agents through deterministic population synthesis methods. However, these deterministic population synthesis methods face several challenges, such as handling high-dimensional data, scalability, and zero-cell issues, particularly when generating populations for target scenarios. This research looks into how a deep generative model called Conditional Tabular Generative Adversarial Network (CT-GAN) can be used to create target populations either directly from a collection of marginal constraints or through a hybrid method that combines CT-GAN with Fitness-based Synthesis Combinatorial Optimization (FBS-CO). The research evaluates the proposed population synthesis models against travel survey and zonal-level aggregated population data. Results indicate that the stand-alone CT-GAN model performs the best when compared with FBS-CO and the hybrid model. CT-GAN by itself can create realistic-looking groups that match single-variable distributions, but it struggles to maintain relationships between multiple variables. However, the hybrid model demonstrates improved performance compared to FBS-CO by leveraging CT-GAN ability to generate a descriptive base population, which is then refined using FBS-CO to align with target-year marginals. This study demonstrates that CT-GAN represents an effective methodology for target populations and highlights how deep generative models can be successfully integrated with conventional synthesis techniques to enhance their performance.