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CytoDiff: AI-Driven Cytomorphology Image Synthesis for Medical Diagnostics

Boada, Jan Carreras, Umer, Rao Muhammad, Marr, Carsten

arXiv.org Artificial Intelligence

Biomedical datasets are often constrained by stringent privacy requirements and frequently suffer from severe class imbalance. These two aspects hinder the development of accurate machine learning models. While generative AI offers a promising solution, producing synthetic images of sufficient quality for training robust classifiers remains challenging. This work addresses the classification of individual white blood cells, a critical task in diagnosing hematological malignancies such as acute myeloid leukemia (AML). We introduce CytoDiff, a stable diffusion model fine-tuned with LoRA weights and guided by few-shot samples that generates high-fidelity synthetic white blood cell images. Our approach demonstrates substantial improvements in classifier performance when training data is limited. Using a small, highly imbalanced real dataset, the addition of 5,000 synthetic images per class improved ResNet classifier accuracy from 27\% to 78\% (+51\%). Similarly, CLIP-based classification accuracy increased from 62\% to 77\% (+15\%). These results establish synthetic image generation as a valuable tool for biomedical machine learning, enhancing data coverage and facilitating secure data sharing while preserving patient privacy. Paper code is publicly available at https://github.com/JanCarreras24/CytoDiff.


Improving Physical Object State Representation in Text-to-Image Generative Systems

Chen, Tianle, Chakka, Chaitanya, Ghadiyaram, Deepti

arXiv.org Artificial Intelligence

Current text-to-image generative models struggle to accurately represent object states (e.g., "a table without a bottle," "an empty tumbler"). In this work, we first design a fully-automatic pipeline to generate high-quality synthetic data that accurately captures objects in varied states. Next, we fine-tune several open-source text-to-image models on this synthetic data. We evaluate the performance of the fine-tuned models by quantifying the alignment of the generated images to their prompts using GPT4o-mini, and achieve an average absolute improvement of 8+% across four models on the public GenAI-Bench dataset. We also curate a collection of 200 prompts with a specific focus on common objects in various physical states. We demonstrate a significant improvement of an average of 24+% over the baseline on this dataset. We release all evaluation prompts and code.


MESA: Text-Driven Terrain Generation Using Latent Diffusion and Global Copernicus Data

Borne--Pons, Paul, Czerkawski, Mikolaj, Martin, Rosalie, Rouffet, Romain

arXiv.org Artificial Intelligence

It is a complex and time-consuming task, particularly when it involves large-scale landscapes, which are getting more common with the current boom in popularity of open world games. The current state-of-the-art (SOT A) in terrain modeling relies mainly on procedural and simulation methods [8], which rarely scale well beyond a certain point (compute expensive or lack of realism) and can easily fail to capture the variety of the landscape the world offers. The recent advances in generative machine learning and especially in the area of diffusion models have paved the way for models that can learn a representation of Earth's landscapes directly from real terrain data. By abstracting the complexity of the underlying physical processes, generative models can learn to reproduce patterns and mutual dependencies between visual features, which can lead to* First author high levels of perceptual realism. This work explores the potential of following a similar data-centric methodology for a joint domain of terrain surface model and optical reflectance.


Your Image Generator Is Your New Private Dataset

Resmini, Nicolo, Lomurno, Eugenio, Sbrolli, Cristian, Matteucci, Matteo

arXiv.org Artificial Intelligence

Generative diffusion models have emerged as powerful tools to synthetically produce training data, offering potential solutions to data scarcity and reducing labelling costs for downstream supervised deep learning applications. However, effectively leveraging text-conditioned image generation for building classifier training sets requires addressing key issues: constructing informative textual prompts, adapting generative models to specific domains, and ensuring robust performance. This paper proposes the Text-Conditioned Knowledge Recycling (TCKR) pipeline to tackle these challenges. TCKR combines dynamic image captioning, parameter-efficient diffusion model fine-tuning, and Generative Knowledge Distillation techniques to create synthetic datasets tailored for image classification. The pipeline is rigorously evaluated on ten diverse image classification benchmarks. The results demonstrate that models trained solely on TCKR-generated data achieve classification accuracies on par with (and in several cases exceeding) models trained on real images. Furthermore, the evaluation reveals that these synthetic-data-trained models exhibit substantially enhanced privacy characteristics: their vulnerability to Membership Inference Attacks is significantly reduced, with the membership inference AUC lowered by 5.49 points on average compared to using real training data, demonstrating a substantial improvement in the performance-privacy trade-off. These findings indicate that high-fidelity synthetic data can effectively replace real data for training classifiers, yielding strong performance whilst simultaneously providing improved privacy protection as a valuable emergent property. The code and trained models are available in the accompanying open-source repository.


Neuro-Symbolic Scene Graph Conditioning for Synthetic Image Dataset Generation

Savazzi, Giacomo, Lomurno, Eugenio, Sbrolli, Cristian, Chiatti, Agnese, Matteucci, Matteo

arXiv.org Artificial Intelligence

As machine learning models increase in scale and complexity, obtaining sufficient training data has become a critical bottleneck due to acquisition costs, privacy constraints, and data scarcity in specialised domains. While synthetic data generation has emerged as a promising alternative, a notable performance gap remains compared to models trained on real data, particularly as task complexity grows. Concurrently, Neuro-Symbolic methods, which combine neural networks' learning strengths with symbolic reasoning's structured representations, have demonstrated significant potential across various cognitive tasks. This paper explores the utility of Neuro-Symbolic conditioning for synthetic image dataset generation, focusing specifically on improving the performance of Scene Graph Generation models. The research investigates whether structured symbolic representations in the form of scene graphs can enhance synthetic data quality through explicit encoding of relational constraints. The results demonstrate that Neuro-Symbolic conditioning yields significant improvements of up to +2.59% in standard Recall metrics and +2.83% in No Graph Constraint Recall metrics when used for dataset augmentation. These findings establish that merging Neuro-Symbolic and generative approaches produces synthetic data with complementary structural information that enhances model performance when combined with real data, providing a novel approach to overcome data scarcity limitations even for complex visual reasoning tasks.


Culture-TRIP: Culturally-Aware Text-to-Image Generation with Iterative Prompt Refinment

Jeong, Suchae, Choi, Inseong, Yun, Youngsik, Kim, Jihie

arXiv.org Artificial Intelligence

Text-to-Image models, including Stable Diffusion, have significantly improved in generating images that are highly semantically aligned with the given prompts. However, existing models may fail to produce appropriate images for the cultural concepts or objects that are not well known or underrepresented in western cultures, such as `hangari' (Korean utensil). In this paper, we propose a novel approach, Culturally-Aware Text-to-Image Generation with Iterative Prompt Refinement (Culture-TRIP), which refines the prompt in order to improve the alignment of the image with such culture nouns in text-to-image models. Our approach (1) retrieves cultural contexts and visual details related to the culture nouns in the prompt and (2) iteratively refines and evaluates the prompt based on a set of cultural criteria and large language models. The refinement process utilizes the information retrieved from Wikipedia and the Web. Our user survey, conducted with 66 participants from eight different countries demonstrates that our proposed approach enhances the alignment between the images and the prompts. In particular, C-TRIP demonstrates improved alignment between the generated images and underrepresented culture nouns. Resource can be found at https://shane3606.github.io/Culture-TRIP.


Enhancing Compositional Text-to-Image Generation with Reliable Random Seeds

Li, Shuangqi, Le, Hieu, Xu, Jingyi, Salzmann, Mathieu

arXiv.org Artificial Intelligence

Text-to-image diffusion models have demonstrated remarkable capability in generating realistic images from arbitrary text prompts. However, they often produce inconsistent results for compositional prompts such as "two dogs" or "a penguin on the right of a bowl". Understanding these inconsistencies is crucial for reliable image generation. In this paper, we highlight the significant role of initial noise in these inconsistencies, where certain noise patterns are more reliable for compositional prompts than others. Our analyses reveal that different initial random seeds tend to guide the model to place objects in distinct image areas, potentially adhering to specific patterns of camera angles and image composition associated with the seed. To improve the model's compositional ability, we propose a method for mining these reliable cases, resulting in a curated training set of generated images without requiring any manual annotation. By fine-tuning text-to-image models on these generated images, we significantly enhance their compositional capabilities. For numerical composition, we observe relative increases of 29.3% and 19.5% for Stable Diffusion and PixArt-{\alpha}, respectively. Spatial composition sees even larger gains, with 60.7% for Stable Diffusion and 21.1% for PixArt-{\alpha}.