Research links variations in the gene GRIN2A to a higher risk of developing schizophrenia and other forms of mental illness. A team of physicians specializing in genetics and neurology discovered that mental illnesses such as schizophrenia are closely linked to mutations in the GRIN2A gene. The scientists mantain that identifying this genetic risk factor opens up the possibility of designing preventive therapies in the future. The GRIN2A gene regulates communication between neurons by producing the GluN2A protein. When functioning optimally, it promotes the transmission of electrical signals between nerve cells and facilitates essential processes such as learning, memory, language, and brain development.

This work examines how three different image-based methods, VGG16, ViT-B/16, and CoAtNet-Tiny, perform in identifying depression, schizophrenia, and healthy controls using daily actigraphy records. Wrist-worn activity signals from the Psykose and Depresjon datasets were converted into 30 48 images and evaluated through a three-fold subject-wise split. Although all methods fitted the training data well, their behaviour on unseen data differed. VGG16 improved steadily but often settled at lower accuracy. ViT-B/16 reached strong results in some runs, but its performance shifted noticeably from fold to fold. CoAtNet-Tiny stood out as the most reliable, recording the highest average accuracy and the most stable curves across folds. It also produced the strongest precision, recall, and F1-scores, particularly for the underrepresented depression and schizophrenia classes. Overall, the findings indicate that CoAtNet-Tiny performed most consistently on the actigraphy images, while VGG16 and ViT-B/16 yielded mixed results. These observations suggest that certain hybrid designs may be especially suited for mental-health work that relies on actigraphy-derived images. I. Introduction Mental health disorders such as depression and schizophrenia constitute a significant and growing global health challenge, with profound impacts on individuals, families, and healthcare systems worldwide. According to the World Health Organization, depression affects over 280 million people.

The human neocortex is functionally organised at its highest level along a continuous sensory-to-association (AS) hierarchy. This study characterises the AS hierarchy of patients with schizophrenia in a comparison with controls. Using a large fMRI dataset (N=355), we extracted individual AS gradients via spectral analysis of brain connectivity, quantified hierarchical specialisation by gradient spread, and related this spread with connectivity geometry. We found that schizophrenia compresses the AS hierarchy indicating reduced functional differentiation. By modelling neural timescale with the Ornstein-Uhlenbeck process, we observed that the most specialised, locally cohesive regions at the gradient extremes exhibit dynamics with a longer time constant, an effect that is attenuated in schizophrenia. To study computation, we used the gradients to regularise subject-specific recurrent neural networks (RNNs) trained on working memory tasks. Networks endowed with greater gradient spread learned more efficiently, plateaued at lower task loss, and maintained stronger alignment to the prescribed AS hierarchical geometry. Fixed point linearisation showed that high-range networks settled into more stable neural states during memory delay, evidenced by lower energy and smaller maximal Jacobian eigenvalues. This gradient-regularised RNN framework therefore links large-scale cortical architecture with fixed point stability, providing a mechanistic account of how gradient de-differentiation could destabilise neural computations in schizophrenia, convergently supported by empirical timescale flattening and model-based evidence of less stable fixed points.

Advances in artificial intelligence (AI) and deep learning have improved diagnostic capabilities in healthcare, yet limited interpretability continues to hinder clinical adoption. Schizophrenia, a complex disorder with diverse symptoms including disorganized speech and social withdrawal, demands tools that capture symptom severity and provide clinically meaningful insights beyond binary diagnosis. Here, we present an interpretable framework that leverages articulatory speech features through eigenspectra difference plots and a weighted sum with exponential decay (WSED) to quantify vocal tract coordination. Eigenspectra plots effectively distinguished complex from simpler coordination patterns, and WSED scores reliably separated these groups, with ambiguity confined to a narrow range near zero. Importantly, WSED scores correlated not only with overall BPRS severity but also with the balance between positive and negative symptoms, reflecting more complex coordination in subjects with pronounced positive symptoms and the opposite trend for stronger negative symptoms. This approach offers a transparent, severity-sensitive biomarker for schizophrenia, advancing the potential for clinically interpretable speech-based assessment tools.

The development of diagnostic models is gaining traction in the field of psychiatric disorders. Recently, machine learning classifiers based on resting-state functional magnetic resonance imaging (rs-fMRI) have been developed to identify brain biomarkers that differentiate psychiatric disorders from healthy controls. However, conventional machine learning-based diagnostic models often depend on extensive feature engineering, which introduces bias through manual intervention. While deep learning models are expected to operate without manual involvement, their lack of interpretability poses significant challenges in obtaining explainable and reliable brain biomarkers to support diagnostic decisions, ultimately limiting their clinical applicability. In this study, we introduce an end-to-end innovative graph neural network framework named BrainIB++, which applies the information bottleneck (IB) principle to identify the most informative data-driven brain regions as subgraphs during model training for interpretation. We evaluate the performance of our model against nine established brain network classification methods across three multi-cohort schizophrenia datasets. It consistently demonstrates superior diagnostic accuracy and exhibits generalizability to unseen data. Furthermore, the subgraphs identified by our model also correspond with established clinical biomarkers in schizophrenia, particularly emphasizing abnormalities in the visual, sensorimotor, and higher cognition brain functional network. This alignment enhances the model's interpretability and underscores its relevance for real-world diagnostic applications.

In the United States, schizophrenia (SCZ) carries a race and sex disparity that may be explained by clinician bias - a belief held by a clinician about a patient that prevents impartial clinical decision making. The emergency department (ED) is marked by higher rates of stress that lead to clinicians relying more on implicit biases during decision making. In this work, we considered a large cohort of psychiatric patients in the ED from the Mount Sinai Health System (MSHS) in New York City to investigate the effects of clinician bias on SCZ diagnosis while controlling for known risk factors and patient sociodemographic information. Clinician bias was quantified as the ratio of negative to total sentences within a patient's first ED note. We utilized a logistic regression to predict SCZ diagnosis given patient race, sex, age, history of trauma or substance use disorder, and the ratio of negative sentences. Our findings showed that an increased ratio of negative sentences is associated with higher odds of obtaining a SCZ diagnosis [OR (95% CI)=1.408 (1.361-1.456)]. Identifying as male [OR (95% CI)=1.112 (1.055-1.173)] or Black [OR (95% CI)=1.081(1.031-1.133)] increased one's odds of being diagnosed with SCZ. However, from an intersectional lens, Black female patients with high SES have the highest odds of obtaining a SCZ diagnosis [OR (95% CI)=1.629 (1.535-1.729)]. Results such as these suggest that SES does not act as a protective buffer against SCZ diagnosis in all patients, demanding more attention to the quantification of health disparities. Lastly, we demonstrated that clinician bias is operational with real world data and related to increased odds of obtaining a stigmatizing diagnosis such as SCZ.

Existing deep learning models for functional MRI-based classification have limitations in network architecture determination (relying on experience) and feature space fusion (mostly simple concatenation, lacking mutual learning). Inspired by the human brain's mechanism of updating neural connections through learning and decision-making, we proposed a novel BRain-Inspired feature Fusion (BRIEF) framework, which is able to optimize network architecture automatically by incorporating an improved neural network connection search (NCS) strategy and a Transformer-based multi-feature fusion module. Specifically, we first extracted 4 types of fMRI temporal representations, i.e., time series (TCs), static/dynamic functional connection (FNC/dFNC), and multi-scale dispersion entropy (MsDE), to construct four encoders. Within each encoder, we employed a modified Q-learning to dynamically optimize the NCS to extract high-level feature vectors, where the NCS is formulated as a Markov Decision Process. Then, all feature vectors were fused via a Transformer, leveraging both stable/time-varying connections and multi-scale dependencies across different brain regions to achieve the final classification. Additionally, an attention module was embedded to improve interpretability. The classification performance of our proposed BRIEF was compared with 21 state-of-the-art models by discriminating two mental disorders from healthy controls: schizophrenia (SZ, n=1100) and autism spectrum disorder (ASD, n=1550). BRIEF demonstrated significant improvements of 2.2% to 12.1% compared to 21 algorithms, reaching an AUC of 91.5% - 0.6% for SZ and 78.4% - 0.5% for ASD, respectively. This is the first attempt to incorporate a brain-inspired, reinforcement learning strategy to optimize fMRI-based mental disorder classification, showing significant potential for identifying precise neuroimaging biomarkers.

Mental health disorders are rising worldwide. However, the availability of trained clinicians has not scaled proportionally, leaving many people without adequate or timely support. To bridge this gap, recent studies have shown the promise of Artificial Intelligence (AI) to assist mental health diagnosis, monitoring, and intervention. However, the development of efficient, reliable, and ethical AI to assist clinicians is heavily dependent on high-quality clinical training datasets. Despite growing interest in data curation for training clinical AI assistants, existing datasets largely remain scattered, under-documented, and often inaccessible, hindering the reproducibility, comparability, and generalizability of AI models developed for clinical mental health care. In this paper, we present the first comprehensive survey of clinical mental health datasets relevant to the training and development of AI-powered clinical assistants. We categorize these datasets by mental disorders (e.g., depression, schizophrenia), data modalities (e.g., text, speech, physiological signals), task types (e.g., diagnosis prediction, symptom severity estimation, intervention generation), accessibility (public, restricted or private), and sociocultural context (e.g., language and cultural background). Along with these, we also investigate synthetic clinical mental health datasets. Our survey identifies critical gaps such as a lack of longitudinal data, limited cultural and linguistic representation, inconsistent collection and annotation standards, and a lack of modalities in synthetic data. We conclude by outlining key challenges in curating and standardizing future datasets and provide actionable recommendations to facilitate the development of more robust, generalizable, and equitable mental health AI systems.

Relation extraction (RE) is a core task in natural language processing. Traditional approaches typically frame RE as a supervised learning problem, directly mapping context to labels-an approach that often suffers from poor out-of-domain (OOD) generalization. Inspired by the workflow of human annotators, we reframe RE as a reasoning task guided by annotation guidelines and introduce R1-RE, the first reinforcement learning with verifiable reward (RLVR) framework for RE tasks. Our method elicits the reasoning abilities of small language models for annotation tasks, resulting in significantly improved OOD robustness. We evaluate our approach on the public Sem-2010 dataset and a private MDKG dataset. The R1-RE-7B model attains an average OOD accuracy of approximately 70%, on par with leading proprietary models such as GPT-4o. Additionally, our comprehensive analysis provides novel insights into the training dynamics and emergent reasoning behaviors of the RLVR paradigm for RE.

Causal inference in longitudinal biomedical data remains a central challenge, especially in psychiatry, where symptom heterogeneity and latent confounding frequently undermine classical estimators. Most existing methods for treatment effect estimation presuppose a fixed outcome variable and address confounding through observed covariate adjustment. However, the assumption of unconfoundedness may not hold for a fixed outcome in practice. To address this foundational limitation, we directly optimize the outcome definition to maximize causal identifiability. Our DEBIAS (Durable Effects with Backdoor-Invariant Aggregated Symptoms) algorithm learns non-negative, clinically interpretable weights for outcome aggregation, maximizing durable treatment effects and empirically minimizing both observed and latent confounding by leveraging the time-limited direct effects of prior treatments in psychiatric longitudinal data. The algorithm also furnishes an empirically verifiable test for outcome unconfoundedness. DEBIAS consistently outperforms state-of-the-art methods in recovering causal effects for clinically interpretable composite outcomes across comprehensive experiments in depression and schizophrenia.