ruiz
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Exploring proteomic signatures in sepsis and non-infectious systemic inflammatory response syndrome
Ruiz-Sanmartín, Adolfo, Ribas, Vicent, Suñol, David, Chiscano-Camón, Luis, Martín, Laura, Bajaña, Iván, Bastida, Juliana, Larrosa, Nieves, González, Juan José, Carrasco, M Dolores, Canela, Núria, Ferrer, Ricard, Ruiz-Rodrígue, Juan Carlos
ABSTRACT 2 Background: The search for new biomarkers that allow an early diagnosis in sepsis has become a necessity in medicine. The objective of this study is to identify potential protein biomarkers of differential expression between sepsis and non - infectious systemic inflamm atory response syndrome (NISIRS). Methods: Prospective observational study of a cohort of septic patients activated by the Sepsis Code and patients admitted with NISIRS, during the period 2016 - 2017. A mass spectrometry - based approach was used to analyze the plasma proteins in the enrolled subjects . Subsequently, using recursive feature elimination (RFE) classification and cross - validation with a vector classifier, an association of these proteins in patients with sepsis compared to patients with NISIRS. The protein - protein interaction netwo rk was analyzed with String software. Results: A total of 277 patients (141 with sepsis and 136 with NISIRS) were included. Conclusion: There are proteomic patterns associated with sepsis compared to NISIRS with different strength of association. Advances in understanding these protein changes may allow for the identification of new biomarkers or therapeutic targets in the future. Key words: Sepsis, Septic shock, SIRS, Proteomics, Omics, Diagnosis INTRODUCTION 3 Sepsis is known as a clinical syndrome where life - threatening organ dysfunction occurs due to a dysregulated host response to infection.
Neural Dynamic Focused Topic Model
Cvejoski, Kostadin, Sánchez, Ramsés J., Ojeda, César
Topic models and all their variants analyse text by learning meaningful representations through word co-occurrences. As pointed out by Williamson et al. (2010), such models implicitly assume that the probability of a topic to be active and its proportion within each document are positively correlated. This correlation can be strongly detrimental in the case of documents created over time, simply because recent documents are likely better described by new and hence rare topics. In this work we leverage recent advances in neural variational inference and present an alternative neural approach to the dynamic Focused Topic Model. Indeed, we develop a neural model for topic evolution which exploits sequences of Bernoulli random variables in order to track the appearances of topics, thereby decoupling their activities from their proportions. We evaluate our model on three different datasets (the UN general debates, the collection of NeurIPS papers, and the ACL Anthology dataset) and show that it (i) outperforms state-of-the-art topic models in generalization tasks and (ii) performs comparably to them on prediction tasks, while employing roughly the same number of parameters, and converging about two times faster. Source code to reproduce our experiments is available online.
Would You Like Fries With That? McDonald's Already Knows the Answer
But in the coming years, the company's machine learning technology could change how consumers decide what to eat -- and, in a potentially ominous development for their waistlines, make them eat more. So far, the technological advances can be experienced mostly at the chain's thousands of drive-throughs, where for years menu boards have displayed a familiar array of McDonald's favorites: Big Macs, Quarter Pounders, Chicken McNuggets. Now, the chain has digital boards programmed to market that food more strategically, taking into account such factors as the time of day, the weather, the popularity of certain menu items and the length of the wait. On a hot afternoon, for example, the board might promote soda rather than coffee. At the conclusion of every transaction, screens now display a list of recommendations, nudging customers to order more.
BNamericas - How AI is impacting the mining world
Artificial intelligence is one of a series of technologies that are on the radar for implementation in Chile's mining industry. AI, which, simply put, is the ability of a computer program or machine to think and learn from observing large quantities of data, to identify trends and make recommendations to improve decision making, all in a matter of milliseconds. The impending tsunami of data that will be collected from sensors and internet of things (IoT) devices will be too overwhelming for humans to compute. Businesses that are able to compute and extract value from huge volumes of data are expected to have a key advantage over their competitors by being able to improve efficiency, productivity and lower costs as well as identify new business opportunities. A recent study by consultancy Accenture, showed 82% of executives in the global mining industry expecting to increase investment in digital technology over the next three years.
Using AI, Machine Learning to optimize routes for last-mile operations - Geospatial World
With the help of latest technology, this Spanish startup is working towards making logistics smarter. Scroll through their website and your attention is instantly drawn towards these lines: "You're in good company. Thanks to SmartMonkey, big corporations improve their logistic operations up to 30%. Below these lines are a reiteration of "up to 30% efficiency" and a list of companies that have benefitted from this Spanish startup. Formed in 2015 to make logistics smarter by using Machine Learning and Artificial Intelligence, the startup, in its own words, is "thriving to help companies optimize their distribution routes while learning from their clients' behaviors". "Our clever logistics products improve the companies' distribution operations, reduce the costs besides the operational risks by capturing the drivers' knowledge and transforming it into a new logistics data asset that helps the system learn and operate autonomously," explains SmartMonkey CEO Xavier Ruiz. The company's list of "satisfied" clients includes AGBAR and Heineken. But are clients the only source of revenue for them? "We have two main sources of funding: business angels and venture capital.
Ruiz: Democratizing artificial intelligence and deep learning
Years ago, when I was taking my first steps in computer programming, coding was for geeks and computer programs had limited use. Development tools were very crude, writing code was hard (remember Assembly, C, Pascal?), compiling and linking was a nightmare (MAKE files anyone?), and debugging was even worse. Long story short, programming was not for the faint of heart. You needed nerves of steel and had to patiently fail over and over before you got the hang of writing good code. But as software gradually rose in prominence, the entry barrier to programming lowered.
You could finally control your Facebook data if UK law is passed
Britons might soon be able to request that their embarrassing social media posts be taken down and records of their existence wiped, according to new proposals outlined today. The new bill will transfer the European Union's General Data Protection Regulation into UK law, as well as making a few additions and amendments. It's currently possible to delete any of your own posts manually, but that doesn't necessarily remove the information from social media companies' databases. According to Facebook's terms and conditions, "some things can only be deleted when you permanently delete your account." While not all requests for deletion will be granted – companies can decline on the grounds of freedom of expression, and when the information of scientific or historical importance – those involving information posted by or collected from children will nearly always be honoured.
IBM releases Watson Machine Learning for a general audience - JAXenter
Machine learning is everywhere these days. Whether it's recommending your next movie on Netflix or beating Ken Jennings at Jeopardy, ML is here to stay. But how do you get in on this wave? IBM has just made their new Watson Machine Learning (WML) service generally available this week. I do have to point out that you will need to create an account with Bluemix to start playing around with the service, but there's a 30 day free trial and it's pretty fun.
Google's new NHS deal is start of machine learning marketplace
DeepMind, Google's London-based artificial intelligence company, has started training neural networks to recognise the signs of eye disease in medical images. A partnership with Moorfields Eye Hospital in London has given the company access to about a million anonymised retinal scans, which DeepMind will feed into its artificial intelligence software. The project will target two of the most common eye diseases – age related macular degeneration and diabetic retinopathy. More than 100 million people around the world have these conditions. The information that Moorfields is providing includes scans of the back of people's eyes, as well as more detailed scans known as optical coherence tomography (OCT). The idea is that the images will let DeepMind's neural networks learn to recognise subtle signs of degenerating eye conditions that even trained clinicians have trouble spotting.